Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

González-Lamuño, Domingo; Arrieta-Blanco, Francisco Jesús; Fuentes, Elena Dios; Forga-Visa, María Teresa; Morales-Conejo, Monstserrat; Peña-Quintana, Luis; Vitoria-Miñana, Isidro

doi:10.3390/nu16010135

Cited by 8 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results indicated that increased Met levels were accompanied by increased serum Hcy levels. It is commonly accepted that elevated Hcy is also associated with various conditions, which may be one of the reasons that high TSAA/Lys ratio induced lower feed intake in our study. Additionally, we also observed that there was a significant interaction between sources and levels of the CBS expression and serum levels of Hcy.…”

Section: Discussionmentioning

confidence: 57%

Methionine Source and Level Modulate Gut pH, Amino Acid Transporters and Metabolism Related Genes in Broiler Chickens

Gong,

Xu,

Zhang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

This study determined the effects of two methionine (Met) sources at three total sulfur amino acids (TSAA) to lysine ratios (TSAA/Lys) on gut pH, digestive enzyme activity, amino acid transporter expression, and Met metabolism of broilers. The birds were randomly assigned to a 2 × 3 factorial arrangement with Met sources (DL-Met and DL-2-hydroxy-4-(methylthio)-butanoic acid (OH-Met)) and TSAA/Lys (0.58, 0.73, and 0.88) from 1 to 21 days. The results demonstrated that DL-Met and OH-Met supported the same growth performance, but high TSAA/Lys ratio reduced the feed intake and body weight (P < 0.05). OH-Met reduced the crop chyme pH and enhanced the jejunal lipase activity (P < 0.05). ATB 0,+ expression decreased with increased DL-Met levels in the duodenum; the low TSAA/Lys ratio induced a stronger mRNA expression of basolateral Met transporters. OH-Met resulted in an increase of cystathionine β-synthase expression in the liver and a decrease in serum homocysteine levels at middle TSAA/Lys ratio compared with DL-Met treatment (P < 0.05). In conclusion, two Met sources support the same growth, but OH-Met acidified the crop chyme. The investigated transporter transcripts differed significantly along the small intestine. At the middle TSAA/Lys ratio, OH-Met showed a higher metabolic tendency of the trans-sulfuration pathway compared with DL-Met.

show abstract

Section: Discussionmentioning

confidence: 57%

Methionine Source and Level Modulate Gut pH, Amino Acid Transporters and Metabolism Related Genes in Broiler Chickens

Gong,

Xu,

Zhang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Homocysteine (Hcy) is an intermediate thiol-containing nonproteinogenic amino acid derived from methionine catabolism, which is metabolized via remethylation or trans-sulfuration into cysteine [ 1 ]. Hcy plays a critical role in endothelial dysfunction, atherosclerosis, and thrombosis through various mechanisms, such as inflammation, lipid peroxidation, ferroptosis, and platelet activation [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Association of Plasma Homocysteine Concentrations with a 10-Year Risk of All-Cause and Cardiovascular Mortality in a Community-Based Chinese Population

Liang,

Li,

Chen

et al. 2024

Nutrients

View full text Add to dashboard Cite

This study is aimed to examine the association of plasma homocysteine (Hcy) concentrations with a 10-year risk of all-cause and cardiovascular (CV) mortality and to explore the modification effect of methylenetetrahydrofolate reductase (MTHFR) C677T genetic polymorphism. This study included 5200 participants from a community-based Chinese population. Cox proportional hazard regression models were used to analyze the associations of Hcy and MTHFR C677T genotype with all-cause and CV mortality. The possible modification effect of the MTHFR C677T genotype on the Hcy–mortality relationship was assessed. The individuals with Hcy concentrations ≥ 10 μmol/L had a significantly higher risk of all-cause mortality compared to those with Hcy < 10 μmol/L (hazard ratio [HR]: 1.72, 95% confidence interval [CI]: 1.11–2.68, p = 0.015). The risk of CV mortality increased by 2% per 1 μmol/L Hcy increment (HR: 1.02, 95% CI: 1.00–1.03, p = 0.036). Despite the MTHFR genotype alone not being correlated with the mortality, the relationship between Hcy and all-cause mortality was significant in the CC genotype compared with CT/TT genotype (p for interaction = 0.036). Elevated plasma Hcy concentrations were associated with an increased 10-year risk of all-cause and CV mortality among the Chinese population. MTHFR C677T genetic polymorphism could modify the association between Hcy and all-cause mortality.

show abstract