Hyperhomocysteinemia in patients with diabetes mellitus with and without diabetic retinopathy

Goldstein, Michaela; Leibovitch, Igal; Yeffimov, I; Gavendo, S; Ba, Schölkens; Loewenstein, Anat

doi:10.1038/sj.eye.6700702

Cited by 48 publications

(54 citation statements)

References 56 publications

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“…[57][58][59] It is also true that severity of retinopathy correlates strongly with Hcy level, independent of glycaemic control. 60 Higher Hcy levels are observed in individuals with proliferative retinopathy compared to non-proliferative retinopathy, even though in both instances the levels are significantly elevated compared to control. This occurs despite similar baseline plasma glucose measurements and comparable frequencies of CVD (hypertension, ischaemic heart disease, cerebrovascular accident, thromboembolic event).…”

Section: Diabetic Retinopathymentioning

confidence: 98%

Homocysteine in the Pathogenesis of Chronic Glaucoma

Kadhim¹,

Clement²

2011

The Mystery of Glaucoma

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Section: Diabetic Retinopathymentioning

confidence: 98%

Homocysteine in the Pathogenesis of Chronic Glaucoma

Kadhim¹,

Clement²

2011

The Mystery of Glaucoma

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“…This mutation is a genetic determinant of hyperhomocysteinemia in healthy subjects (Kang et al 1991;Frosst et al 1995) and also in patients with diabetes (Buysschaert et al 2004). Hyperhomocysteinemia induces endothelial dysfunction (Constans et al 1999) and has been implicated as a risk factor for atherosclerosis and atherothrombosis (McCully 1969;Frosst et al 1995) but also for retinopathy in type 1 and in type 2 diabetes patients (Hoogeveen et al 2000;Goldstein et al 2004). Recent in vitro studies indicate that homocysteine and other thiolcontaining reductive compounds (i.e.…”

Section: Discussionmentioning

confidence: 99%

The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis

et al. 2005

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The association between retinopathy in type 2 diabetes [diabetic retinopathy (DR)] and the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been investigated in several case-control studies. These studies rendered contradictory results, some indicating that the polymorphism is associated with the risk of developing DR whereas others concluded there is no association. To shed light on these inconclusive findings, a meta-analysis of all available studies relating the C677T polymorphism to the risk of developing DR was conducted. Four out of five identified studies included populations of East Asian descent, and only one involved samples from European descent (Caucasians). Overall, the meta-analysis suggested large heterogeneity between studies (p = 0.08, I 2 = 52%) and marginal association between C677T transition and the risk of developing DR: random effects odds ratio (OR) = 1. There is a source of bias in the selected studies: the largest studies failed to show association while the smallest study claimed an association. The above findings reinforce the need for larger and more rigourous studies in this area.

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“…A relationship of plasma homocysteine and diabetic retinopathy has been shown in many [11][12][13][14] but not all studies. 15 It is doubtful whether plasma homocysteine is an independent variable for diabetic retinopathy, as several reports suggest that any rise is secondary to renal disease and renal failure, which is often associated with diabetic nephropathy and thus with retinopathy.…”

Section: Diabetic Retinopathymentioning

confidence: 99%