Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis

Holstein, Joerg H.; Herrmann, Markus; Splett, Christina; Herrmann, Wolfgang; Garcia, Patric; Histing, Tina; Klein, Moritz; Kurz, Karsten; Siebel, Thomas; Pohlemann, Tim; Menger, Michael D.

doi:10.1515/cclm.2010.155

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…However, this study could not find a significant relationship between circulating tHcy and morphological or biomechanical properties of bone as assessed by DEXA and histomorphometry [63]. …”

Section: Hcy and Osteoporosismentioning

confidence: 99%

The role of homocysteine in bone remodeling

Vacek

Kalani

Voor

et al. 2013

Clinical Chemistry and Laboratory Medicine

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Bone remodeling is a very complex process. Homocysteine (Hcy) is known to modulate this process via several known mechanisms such as increase in osteoclast activity, decrease in osteoblast activity and direct action of Hcy on bone matrix. Evidence from previous studies further support a detrimental effect on bone via decrease in bone blood flow and an increase in matrix metalloproteinases (MMPs) that degrade extracellular bone matrix. Hcy binds directly to extracellular matrix and reduces bone strength. There are several bone markers that can be used as parameters to determine how high levels of plasma Hcy (hyperhomocysteinemia, HHcy) affect bone such as: hydroxyproline, N-terminal collagen 1 telopeptides. Mitochondrion serves an important role in generating reactive oxygen species (ROS). Mitochondrial abnormalities have been identified during HHcy. The mechanism of Hcy-induced bone remodeling via the mitochondrial pathway is largely unknown. Therefore, we propose a mitochondrial mechanism by which Hcy can contribute to alter bone properties. This may occur both through generations of ROS that activate MMPs and could be extruded into matrix to degrade bone matrix. However, there are contrasting reports on whether Hcy affects bone density, with some reports in favour and others not. Earlier studies also found an alteration in bone biomechanical properties with deficiencies of vitamin B12, folate and HHcy conditions. Moreover, existing data opens speculation that folate and vitamin therapy act not only via Hcy-dependent pathways but also via Hcy-independent pathways. However, more studies are needed to clarify he mechanistic role of Hcy during bone diseases.

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Section: Hcy and Osteoporosismentioning

confidence: 99%

The role of homocysteine in bone remodeling

Vacek

Kalani

Voor

et al. 2013

Clinical Chemistry and Laboratory Medicine

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“…Sex, race-ethnicity, physical activity, alcohol, smoking, estrogen, and diet all affect the risk of fractures in the older population. Previous studies suggest that elevated serum total homocysteine (tHcy, 9 .13 mmol/L) may be a risk factor for poor bone health (2), including low bone mineral density (BMD) (3)(4)(5)(6), bone fracture (7)(8)(9)(10), and osteoporosis (11)(12)(13), but the data are equivocal (14,15). Further evidence that tHcy is related to bone health comes from the genetic disease homocystinuria in which brittle bones are seen, even in young children (16).…”

Section: Introductionmentioning

confidence: 99%

B-vitamin status and bone mineral density and risk of lumbar osteoporosis in older females in the United States

Bailey

Looker

Lü

et al. 2015

The American Journal of Clinical Nutrition

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“…A study in hip arthroplasty patients because of osteoarthritis, tried to investigate the link of serum tHcy levels with osteoarthritis. But this study could not establish any noteworthy association of tHcy levels with biomechanical or morphological bone characteristics as evaluated by histomorphometry and DEXA [54]. Bayhan et al, (2009) demonstrated that elevated tHcy levels appear to influence bone quality and fracture risk, but there have been no distinguishing alterations in bone density [51].…”

Section: Hcy and Bone Interaction: Conflicts And Evidencesmentioning

confidence: 60%

Homocysteine and Leptin in the Pathogenesis of Osteoporosis — Evidences, Conflicts and Expectations

Baig¹,

Tariq²,

Tariq³

2015

Advances in Osteoporosis

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Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis

Abstract: The results of the present study do not indicate a significant relationship between circulating HCY concentrations and morphological or biomechanical bone properties in humans with OA of the hip.

Cited by 10 publications

References 38 publications

The role of homocysteine in bone remodeling

The role of homocysteine in bone remodeling

B-vitamin status and bone mineral density and risk of lumbar osteoporosis in older females in the United States

Homocysteine and Leptin in the Pathogenesis of Osteoporosis — Evidences, Conflicts and Expectations

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