Hyperhomocysteinemia, Lifestyle Factors and Cognitive Impairment in Healthy Older Subjects in Jordan

Mashal, Rima H.

doi:10.3923/pjn.2013.71.79

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…Among them, 34 articles were excluded because of insufficient data (n = 15), irrelevant outcomes (n = 10), irrelevant study design (n = 6), identical trial (n = 2), and sharing participants with another study (n = 1). The remaining 20 studies (six cross-sectional studies, fiver case-control studies, and nine cohort studies) from 19 articles [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,35,36,37,38] were included in the final analysis.…”

Section: Resultsmentioning

confidence: 99%

“…For studies reporting age and sex at the time of the enrollment period, the mean age of the study participants was 71.9 (range, 45 to 108 years), and 51.8% of them were women. The included studies were published from 1990 to 2014, spanning 24 years and were performed in the following countries: China (n = 3) [12,13,38], Finland (n = 2) [23,24], Portugal (n = 2) [18,25], USA (n = 3) [19,21,35], Australia (n = 1) [16], Canada (n = 1) [20], France (n = 1) [22], Norway (n = 1) [14], Taiwan (n = 1) [15], England (n = 1) [17], Japan (n = 2) [11,37], and Jordan (n = 1) [36]. In cohort studies, follow-up periods ranged between 1.3 years and 28 years (mean, 8.4 years), and the completeness of follow-up ranged from 58.2 to 98.2% (mean, 75.8%).…”

Section: Resultsmentioning

confidence: 99%

“…In cohort studies, follow-up periods ranged between 1.3 years and 28 years (mean, 8.4 years), and the completeness of follow-up ranged from 58.2 to 98.2% (mean, 75.8%). Regarding caffeine sources, five studies [18,19,22,25,35] presented an estimated amount of caffeine intake; eight studies [11,12,15,16,20,23,36,37] presented both coffee and tea intake; five studies [13,14,17,21,38] presented only tea intake; and one study [24] presented only coffee intake. Highest categories of caffeine intake in each study ranged from more than 3 times per week to 8 cups per day as coffee units.…”

Section: Resultsmentioning

confidence: 99%

“…Also, we examined a comprehensive meta-analysis including more cohort studies [37,38], case-control studies [17,19,35] and cross-sectional studies [11,13,14,15,36] than the previous one.…”

Section: Discussionmentioning

confidence: 99%

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Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Kim

Kwak

Myung³

2015

Neuroepidemiology

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Background: Observational epidemiological studies such as cross-sectional, case-control, and cohort studies have reported inconsistent findings regarding the association between caffeine intake from coffee or tea and the risk of cognitive disorders such as dementia, Alzheimer's disease, cognitive impairment, and cognitive decline. Methods: We searched PubMed and EMBASE in September 2014. Three evaluators independently extracted and reviewed articles, based on predetermined selection criteria. Results: Out of 293 articles identified through the search and bibliographies of relevant articles, 20 epidemiological studies from 19 articles, which involved 31,479 participants (8,398 in six cross-sectional studies, 4,601 in five case-control studies, and 19,918 in nine cohort studies), were included in the final analysis. The pooled odds ratio (OR) or relative risk (RR) of caffeine intake from coffee or tea for cognitive disorders (dementia, Alzheimer's disease, cognitive impairment, and cognitive decline) was 0.82 (95% confidence interval [CI], 0.67-1.01, I² = 63.2%) in a random-effects meta-analysis. In the subgroup meta-analysis by caffeine sources, the summary OR or RR of coffee intake was 0.83 (95% CI, 0.70-0.98; I² = 44.8%). However, in the subgroup meta-analysis by study design, the summary estimates (RR or OR) of coffee intake for cognitive disorders were 0.70 (95% CI, 0.50-0.98; I² = 42.0%) for cross-sectional studies, 0.82 (95% CI, 0.55-1.24; I² = 33.4%) for case-control studies, and 0.90 (95% CI, 0.59-1.36; I² = 60.0%) for cohort studies. Conclusions: This meta-analysis found that caffeine intake from coffee or tea was not associated with the risk of cognitive disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Also, we examined a comprehensive meta-analysis including more cohort studies [37,38], case-control studies [17,19,35] and cross-sectional studies [11,13,14,15,36] than the previous one.…”

Section: Discussionmentioning

confidence: 99%

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Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Kim

Kwak

Myung³

2015

Neuroepidemiology

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“…Thus, a considerable amount of evidence has indicated an inverse association of tea consumption with cognitive impairment, whereas several studies have failed to show such an association [ 20 , 21 , 22 , 23 , 25 , 28 , 29 , 30 , 31 , 32 , 33 ] ( Table 1 ). Several examples showing no or even unfavorable association are discussed next.…”

Section: Observational Epidemiological Studiesmentioning

confidence: 99%

Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases

et al. 2018

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Tea is one of the most consumed beverages in the world. Green tea, black tea, and oolong tea are made from the same plant Camellia sinensis (L.) O. Kuntze. Among them, green tea has been the most extensively studied for beneficial effects on diseases including cancer, obesity, diabetes, and inflammatory and neurodegenerative diseases. Several human observational and intervention studies have found beneficial effects of tea consumption on neurodegenerative impairment, such as cognitive dysfunction and memory loss. These studies supported the basis of tea’s preventive effects of Parkinson’s disease, but few studies have revealed such effects on Alzheimer’s disease. In contrast, several human studies have not reported these favorable effects with regard to tea. This discrepancy may be due to incomplete adjustment of confounding factors, including the method of quantifying consumption, beverage temperature, cigarette smoking, alcohol consumption, and differences in genetic and environmental factors, such as race, sex, age, and lifestyle. Thus, more rigorous human studies are required to understand the neuroprotective effect of tea. A number of laboratory experiments demonstrated the benefits of green tea and green tea catechins (GTCs), such as epigallocatechin gallate (EGCG), and proposed action mechanisms. The targets of GTCs include the abnormal accumulation of fibrous proteins, such as Aβ and α-synuclein, inflammation, elevated expression of pro-apoptotic proteins, and oxidative stress, which are associated with neuronal cell dysfunction and death in the cerebral cortex. Computational molecular docking analysis revealed how EGCG can prevent the accumulation of fibrous proteins. These findings suggest that GTCs have the potential to be used in the prevention and treatment of neurodegenerative diseases and could be useful for the development of new drugs.

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Nutraceuticals Supporting Cognitive Function in Mild Cognitive Impairment

Strilchuk

2021

Contemporary Cardiology

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Hyperhomocysteinemia, Lifestyle Factors and Cognitive Impairment in Healthy Older Subjects in Jordan

Cited by 4 publications

References 8 publications

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases

Nutraceuticals Supporting Cognitive Function in Mild Cognitive Impairment

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