Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo

Valentão, Patrı́cia; Carvalho, Márcia; Carvalho, Félix; Fernandes, Eduarda; Neves, Ricardo Pires das; Pereira, Maria de Lourdes; Andrade, Paula B.; Seabra, Rosa M.; Bastos, Maria de Lourdes

doi:10.1016/j.jep.2004.06.012

Cited by 27 publications

(12 citation statements)

References 20 publications

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“…Results from this study confirmed t -BHP-induced hepatotoxic effects as shown by the significant increase in the activity of ALT, AST and LDH in the serum of t -BHP-treated rats. These observations are in accordance with those obtained by previous studies [66, 87–89]. Alanine amino transferase, AST, and LDH are cytoplasmic, and the rise in their serum levels is attributed to damaged structural integrity of the liver and as a result these enzymes are released into the blood circulation after the rupture of the plasma membranes [66, 90].…”

Section: Discussionsupporting

confidence: 92%

Protective Effects of Rooibos (Aspalathus linearis) and/or Red Palm Oil (Elaeis guineensis) Supplementation ontert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

Ajuwon

Katengua-Thamahane

Rooyen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The possible protective effects of an aqueous rooibos extract (Aspalathus linearis), red palm oil (RPO) (Elaeis guineensis), or their combination on tert-butyl-hydroperoxide-(t-BHP-)induced oxidative hepatotoxicity in Wistar rats were investigated. tert-butyl hydroperoxide caused a significant (P < 0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly (P < 0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver. This apparent oxidative injury was associated with histopathological changes in liver architecture and elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). Supplementation with rooibos, RPO, or their combination significantly (P < 0.05) decreased CD and MDA levels in the liver and reduced serum level of ALT, AST, and LDH. Likewise, changes observed in the activities of antioxidant enzymes and impairment in redox status in the erythrocytes and liver were reversed. The observed protective effects when rooibos and RPO were supplemented concomitantly were neither additive nor synergistic. Our results suggested that rooibos and RPO, either supplemented alone or combined, are capable of alleviating t-BHP-induced oxidative hepatotoxicity, and the mechanism of this protection may involve inhibition of lipid peroxidation and modulation of antioxidants enzymes and glutathione status.

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Section: Discussionsupporting

confidence: 92%

Protective Effects of Rooibos (Aspalathus linearis) and/or Red Palm Oil (Elaeis guineensis) Supplementation ontert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

Ajuwon

Katengua-Thamahane

Rooyen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Results from this study confirmed t-BHP-induced hepatotoxic effects as shown by the significant increase in the activity of ALT, AST and LDH in the serum of t-BHPtreated rats. These observations are in accordance with those obtained by previous studies [66,[87][88][89]. Alanine amino transferase, AST, and LDH are cytoplasmic, and the rise in their serum levels is attributed to damaged structural Evidence-Based Complementary and Alternative Medicine 13 integrity of the liver and as a result these enzymes are released into the blood circulation after the rupture of the plasma membranes [66,90].…”

Section: Discussionsupporting

confidence: 92%

Protective Effects of Rooibos (Aspalathus Linearis) and/or Red Palm Oil (Elaeis Guineensis) Supplementation on Tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

Ajuwon

Katengua-Thamahane

Rooyen

et al. 2012

Free Radical Biology and Medicine

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The possible protective effects of an aqueous rooibos extract (Aspalathus linearis), red palm oil (RPO) (Elaeis guineensis), or their combination on tert-butyl-hydroperoxide-(t-BHP-)induced oxidative hepatotoxicity in Wistar rats were investigated. tert-butyl hydroperoxide caused a significant ( < 0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly ( < 0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver. This apparent oxidative injury was associated with histopathological changes in liver architecture and elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). Supplementation with rooibos, RPO, or their combination significantly ( < 0.05) decreased CD and MDA levels in the liver and reduced serum level of ALT, AST, and LDH. Likewise, changes observed in the activities of antioxidant enzymes and impairment in redox status in the erythrocytes and liver were reversed. The observed protective effects when rooibos and RPO were supplemented concomitantly were neither additive nor synergistic. Our results suggested that rooibos and RPO, either supplemented alone or combined, are capable of alleviating t-BHP-induced oxidative hepatotoxicity, and the mechanism of this protection may involve inhibition of lipid peroxidation and modulation of antioxidants enzymes and glutathione status.

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“…In many cases, however, these actions have not been demonstrated by specific experiments, and there is no actual evidence that the extracts of Hypericum species different from H. perforatum are effective for the claimed uses. Otherwise, from a survey in the literature, opposite evidences show up, as for example the demonstrated hepatotoxic activity of H. androsaemum or the mutagenicity of H. triquetrifolium . A proper characterization of all Hypericum species, to avoid frauds or unintentional misuses, is therefore advocated …”

Section: Introductionmentioning

confidence: 99%

Variability of Hypericins and Hyperforin inHypericumSpecies from the Sicilian Flora

Lazzara¹,

Carrubba

Napoli

2020

Chemistry & Biodiversity

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Within Sicilian flora, the genus Hypericum (Guttiferae) includes 10 native species, the most popular of which is H. perforatum. Hypericum's most investigated active compounds belong to naphtodianthrones (hypericin, pseudohypericin) and phloroglucinols (hyperforin, adhyperforin), and the commercial value of the drug is graded according to its total hypericin content. Ethnobotanical sources attribute the therapeutic properties recognized for H. perforatum, also to other Hypericum species. However, their smaller distribution inside the territory suggests that an industrial use of such species, when collected from the wild, would result in an unacceptable depletion of their natural stands. This study investigated about the potential pharmacological properties of 48 accessions from six native species of Hypericum, including H. perforatum and five 'minor' species, also comparing, when possible, wild and cultivated sources. The variability in the content of active metabolites was remarkably high, and the differences within the species were often comparable to the differences among species. No difference was enlightened between wild and cultivated plants. A carefully planned cultivation of Hypericum seems the best option to achieve high and steady biomass yields, but there is a need for phytochemical studies, aimed to identify for multiplication the genotypes with the highest content of the active metabolites.

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Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo

Cited by 27 publications

References 20 publications

Protective Effects of Rooibos (Aspalathus linearis) and/or Red Palm Oil (Elaeis guineensis) Supplementation ontert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

Protective Effects of Rooibos (Aspalathus linearis) and/or Red Palm Oil (Elaeis guineensis) Supplementation ontert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

Protective Effects of Rooibos (Aspalathus Linearis) and/or Red Palm Oil (Elaeis Guineensis) Supplementation on Tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

Variability of Hypericins and Hyperforin inHypericumSpecies from the Sicilian Flora

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