Hyperinsulinemia in colon, stomach and breast cancer patients

Yam, D.; Fink, Aaron S.; Mashiah, A; Ben-Hur, Ertzel

doi:10.1016/0304-3835(96)04211-5

Cited by 35 publications

(20 citation statements)

References 15 publications

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“…Previously, the links between insulin resistance, obesity, and CRC have been noted, and therefore the important roles of insulin pathway in the etiology of CRC have been clarified (Yam et al, 1996;Tamakoshi et al, 2004). The potential associations between variants of genes encoding components of the insulin pathway and risk of CRC have been investigated in limited studies.…”

Section: Discussionmentioning

confidence: 99%

Is there an Association between Variants in Candidate Insulin Pathway Genes IGF-I, IGFBP-3, INSR, and IRS2 and Risk of Colorectal Cancer in the Iranian Population?

Karimi¹,

Mahmoudi²,

Karimi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Several epidemiological studies have shown associations between colorectal cancer (CRC) risk and type 2 diabetes and obesity. Any effects would be expected to be mediated through the insulin pathway. Therefore it is possible that variants of genes encoding components of the insulin pathway play roles in CRC susceptibility. In this study, we hypothesized that polymorphisms in the genes involving the insulin pathway are associated with risk of CRC.

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Section: Discussionmentioning

confidence: 99%

Is there an Association between Variants in Candidate Insulin Pathway Genes IGF-I, IGFBP-3, INSR, and IRS2 and Risk of Colorectal Cancer in the Iranian Population?

Karimi¹,

Mahmoudi²,

Karimi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…IGF-1 and IGFBP-3 have been evaluated with cancer because of their mitogenic properties as well as because of the co-regulatory effects on estrogen and insulin-like growth factor signaling [30,31], two pathways that may be important for several types of cancers [32][33][34][35]. Studies evaluating associations with serum levels of IGF-1 and IGFBP-3 and breast cancer specifically report mixed results, with positive associations more frequently being reported for pre-menopausal women [36][37][38][39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Genetic, Anthropometric, and Lifestyle Factors Associated with IGF-1 and IGFBP-3 Levels in Hispanic and Non-Hispanic White Women

Slattery

Baumgartner

Byers

et al. 2005

Cancer Causes Control

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Circulating concentrations of IGF-I and IGFBP-3 are associated with risk of pre-menopausal breast cancer. Racial differences in levels of these factors have been reported, and determinants of IGF-I and IGFBP-3 levels within racial and ethnic groups are unclear. In this study we examine genetic, anthropometric, diet, and lifestyle factors that may predict serum levels of IGF-I and IGFBP-3 among Hispanic and non-Hispanic white women. A sample of healthy controls participating in the SHINE (Southwest Hormone, Insulin, Nutrition, and Exercise Study) case-control breast cancer in Arizona, Colorado, New Mexico, and Utah were included in these analyses. Subjects included 210 Hispanic and 284 non-Hispanic white women. Hispanic women had significantly lower levels of IGFBP-3 (mean=3764.3 mcg/ml) after adjusting for age, body size, physical activity, menopausal status, and dietary factors than non-Hispanic white women (mean = 4058.0 mcg/ml; p<0.01). The CC genotype of the -202 A>C polymorphism of the IGFBP3 gene was associated with lower IGFBP-3 levels in both ethnic groups. The frequency of the IGFBP3 C allele differed between Hispanic (0.65) and non-Hispanic white women (0.53), but serum levels of IGFBP-3 were lower for Hispanic women than non-Hispanic after accounting for IGFBP3 genotype. Body size indicators, vigorous physical activity, and dietary factors appeared to influence serum levels of IGF-1 and the ratio of IGF-1 to IGFBP-3 in pre-menopausal women more than in post-menopausal women. On the other hand, using aspirin/NSAIDs appeared to increase IGFBP-3 levels significantly among pre-menopausal Hispanic women. Results from this study suggest that differences in IGFBP-3 levels exist in Hispanic and non-Hispanic white women. These differences could be due to the combined effects of genetic and behavioral factors which could account for ethnic differences in the risk of breast cancer and other chronic diseases.

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“…This syndrome has been estimated to be present in 20-30% of the general population and in 60% of obese individuals. Given that obesity, a key component of this syndrome, has been associated with an increased risk of many cancers [8,9] (including postmenopausal breast cancer [10,11]) and that insulin resistance reflected by high levels of insulin (or its breakdown product C-peptide) have been associated with breast cancer risk in some studies [12][13][14][15][16][17], it is reasonable to postulate that underlying insulin resistance is responsible for hyperinsulinemia in early stage breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome

Goodwin

Ennis

Bahl

et al. 2008

Breast Cancer Res Treat

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Hyperinsulinemia in colon, stomach and breast cancer patients

Cited by 35 publications

References 15 publications

Is there an Association between Variants in Candidate Insulin Pathway Genes IGF-I, IGFBP-3, INSR, and IRS2 and Risk of Colorectal Cancer in the Iranian Population?

Is there an Association between Variants in Candidate Insulin Pathway Genes IGF-I, IGFBP-3, INSR, and IRS2 and Risk of Colorectal Cancer in the Iranian Population?

Genetic, Anthropometric, and Lifestyle Factors Associated with IGF-1 and IGFBP-3 Levels in Hispanic and Non-Hispanic White Women

High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome

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