Hyperkalzaemie und Organverkalkungen bei Boeckscher Krankheit.

SCHüPBACH, A.; M, Wernly

doi:10.1111/j.0954-6820.1943.tb15856.x

Cited by 23 publications

(2 citation statements)

References 6 publications

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“…The serum phosphorus content in sarcoidosis has stimulated much less interest than has serum calcium. A number of cases have been reported with normal serum phosphorus in spite of hypercalcemia (7,14,30,37), yet Longcope and Freiman's study (26) was the first to include serum phosphorus determinations on as many as 40 sarcoidosis patients. These writers referred to their results briefly as follows: "Some variations and occasional low values may occur, but these are unusual" and "phosphorus values ranged from 2.4 to 4.8 mgjlOO cc".…”

Section: Resultsmentioning

confidence: 99%

Calcium and Phosphorus Metabolism in Sarcoidosis

Putkonen

Hannuksela

Halme

1965

Journal of Internal Medicine

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Section: Resultsmentioning

confidence: 99%

Calcium and Phosphorus Metabolism in Sarcoidosis

Putkonen

Hannuksela

Halme

1965

Journal of Internal Medicine

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“…As an alternative hypothesis we suggest the possibility that the excess hypercalcuria is due to mobilization of metastatic calcifications, for the following reasons: 1) In hypercalcemic sarcoidosis, as in vitamin D intoxication, metastatic calcifications are frequently found (7,8,27,40). They are often invisible on X-rays but recognizable by renal biopsy-as in patient 4 (6, 34) and by the renal insufficiency, which is present almost inevitably (26, 34, 48).…”

Section: ) a Mobilization Of Metastatic Calcifications Is Recognized mentioning

confidence: 99%

Observations on the Different Calcium Metabolic Patterns in Sarcoidosis

Hornum

Transbøl

1976

Journal of Internal Medicine

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Combined calcium balance and 47Ca turnover studies in sarcoidosis (4 patients) and vitamin D intoxication (1 patient) disclosed three different patterns of calcium metabolism. One patient with sarcoidosis had a normal metabolism of calcium, and two patients presented the usual pattern of intestinal hyperabsorption, hypercalcemia, and hypercalciuria. The fourth patient with sarcoidosis and the patient with vitamin D intoxication, both studied during spontaneous remissions, presented the third pattern. The main features here were hypercalcemia despite normal intestinal absorption of calcium, enlarged exchangeable calcium pool, accelerated accretion and resorption rates, hypercalciuria, and a distinctly negative calcium balance. This pattern of remission seems to represent a mobilization of extraosseous or metastatic calcifications, rather than a resorption of bone calcium.Hypercalcemia (18) and hypercalciuria are well known complications of sarcoidosis, although their frequency varies considerably, averaging some 10% (14) and 50% (30), respectively. A few investigators have attributed the hypercalciuria to either a primary decrease in the tubular reabsorption of calcium (TRCa) (28), or to excessive bone resorption (21), while the majority ascribe it to an increased intestinal absorption of calcium (1, 4, 23). According to this hypothesis (44) hyperabsorption raises plasma ionized calcium (13, leading to suppression of parathyroid hormone -(PTH) secretion (9, 47) and consequently a decrease in the TRCa (30, 45). This sequence of events appears to result from an increased sensitivity to vitamin D (1, 4, 10, 31). This hypersensitivity may possibly involve the skeleton as well as the intestinal tract (3).Along with our studies of the renal handling of calcium in hypercalcemic disorders reported previously (45, 48) we performed traditional calcium and phosphorus balance and 47Ca kinetic studies in four different types of patients: 1) normocalcemic active sarcoidosis, 2) hypercalcemic active sarcoidosis, 3) hypercalcemic sarcoidosis in spontaneous clinical remission, and 4) vitamin D intoxication in remission.Our observation of two different calciummetabolic patterns in hypercalcemic sarcoidosis, apparently related to the stage of disease, forms the basis of a hypothesis unifying the observations reported hitherto. MATERIALFive patients were studied. A summary of their clinical data is given in Table I. Case reports Patient I . A 54-year-old female with arthralgias, myalgias and intermittent fever for about two years. Erythema nodosum was found on admission. Chest X-ray was normal, but hepatic, musculo-cutaneous and tonsillar biopsies showed epithelioid granulomatous lesions. No abnormalities of the calcium metabolism could be demonstrated. Preliminary data presented in part at the 4th International patient 2, A 58-year-o]d female with conjunctivitis, Sarcoidosis Conference in Pans, Sept. 1%. parotid gland enlargement, fatigue and weight loss for Present address: 'Department of Medicine, Fredericia two years. Uveitis, pe...

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Sarkoidose

Schermuly¹,

Behrend²

1978

Röntgendiagnostik Der Oberen Speise- Und Atemwege, Der Atemorgane Und Des Mediastinums Teil 5a / Roentgendiagnosis of the Upper

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Hyperkalzaemie und Organverkalkungen bei Boeckscher Krankheit.

Cited by 23 publications

References 6 publications

Calcium and Phosphorus Metabolism in Sarcoidosis

Calcium and Phosphorus Metabolism in Sarcoidosis

Observations on the Different Calcium Metabolic Patterns in Sarcoidosis

Sarkoidose

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