Hyperkeratotic nail discoid lupus erythematosus evolving towards systemic lupus erythematosus: therapeutic difficulties

Richert, Bertrand; André, Josette; Bourguignon, R; Brassinne, M de la

doi:10.1111/j.1468-3083.2004.01068.x

Cited by 21 publications

(14 citation statements)

References 6 publications

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“…By contrast, onycholysis was observed in 12 out of 49 patients (24.5%) treated with a metronomic low dose of docetaxel (15 mg/m 2 every week). Onycholysis and subungual hyperkeratosis have also been observed in patients with psoriasis, onychomycosis and certain autoimmune diseases, in addition to malignant tumor patients receiving chemotherapy (18–20). Although their pathological etiology remains to be elucidated, a number of studies support the possibility of a neurological involvement in the pathogenesis of these nail alterations.…”

Section: Discussionmentioning

confidence: 99%

Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy

Kibata¹,

Tamaki²,

Inagaki³

et al. 2013

Oncology Letters

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Docetaxel is a well-known causative agent of nail alterations. The aim of this study was to reveal the impact of nail alterations associated with low-dose metronomic (LDM) docetaxel chemotherapy on the survival of non-small cell lung cancer (NSCLC) patients. Clinical information, survival data and nail alterations in patients treated with LDM docetaxel chemotherapy (docetaxel 15 mg/m2 per week) were retrospectively reviewed. Forty-nine patients were included in this study. Various nail alterations were observed in 17 of the 49 patients (34.7%). Onycholysis and subungual hyperkeratosis were observed in 22.4% and 10.2% of patients, respectively. The number of docetaxel administration cycles was correlated with the incidence and severity of nail alterations. Univariate and multivariate analysis clearly demonstrated that the occurrence of nail alterations was an independent favorable prognostic factor for overall survival. Nail alterations associated with treatment may act as a surrogate marker for the efficacy of low-dose metronomic docetaxel chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy

Kibata¹,

Tamaki²,

Inagaki³

et al. 2013

Oncology Letters

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“…Despite nail abnormalities being found frequent in SLE (25%), 25 permanent deformations are rare, usually secondary to matricial lesions of DLE. 26 In this series, they were only observed in the classic or atrophic variant of digital DLE.…”

Section: Discussionmentioning

confidence: 92%

Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases

Bouaziz¹,

Barète

Pelletier

et al. 2007

Lupus

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The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was previously suggested in 36% of cases. Pictures were reviewed by three dermatologists and all the tissue sections were analysed by the same pathologist. Files of patients were reviewed retrospectively. Activity of SLE was established according to the lupus activity index (LAI). Digital lesions in SLE were frequently painful (60%) with a finger-pulp inflammation (70%). According to clinical and pathological correlation, five patients had acute cutaneous lupus, five subacute cutaneous lupus, 21 discoid lupus and 15 chilblain lupus. Two patients presented vasculitis: one had an urticarial vasculitis concomitantly to a lupus flare, the other had an erythema elevatum diutinum, independent of SLE evolution. Thrombosis of dermal vessels was present in two patients with SLE-associated antiphospholipid syndrome and in two patients with chilblain lupus. LAI was >1.5 in only seven patients. These results highlight the tendency to clinically overestimate the prevalence of cutaneous vasculitis of the fingers in patients without active SLE. Clinical features of cutaneous lupus of the digits are polymorphous. So, a pathological examination of the lesions is often necessary for diagnosis and proper management.

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“…20,101 In systemic lupus erythematosus (SLE), a wide range of nail abnormalities may be observed in 25% to 55% of patients. 103,104 None of them are sufficiently distinctive to allow a definitive diagnosis. 103,105,106 Erythema and telangiectasia of the proximal nailfold (Fig.…”

Section: Yellow Nail Syndromementioning

confidence: 99%

“…103,104 None of them are sufficiently distinctive to allow a definitive diagnosis. 103,105,106 Erythema and telangiectasia of the proximal nailfold (Fig. 9), splinter hemorrhages, thinning of the plate, longitudinal ridging, melanonychia, ventral pterygium, and red lunula are frequently described.…”

Section: Yellow Nail Syndromementioning

confidence: 99%

Nail is Systemic Disorders: Main Signs and Clues

Dehavay

Richert

2021

Dermatologic Clinics

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Nail alterations are common in systemic diseases, but most of them are not specific. Typical nail signs for systemic disease are rare, but should not be missed. Some nail signs should suggest a systemic disease, especially if present on several digits: Beau's lines, onychomadesis, splinter hemorrhages, clubbing, apparent leukonychia, abnormal nail fold capillaries, melanonychia, red lunula and pterygium inversum unguis.

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Hyperkeratotic nail discoid lupus erythematosus evolving towards systemic lupus erythematosus: therapeutic difficulties

Cited by 21 publications

References 6 publications

Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy

Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy

Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases

Nail is Systemic Disorders: Main Signs and Clues

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