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Background: The objective of our study is to investigate the relationship between ligament hyperlaxity and adolescent idiopathic scoliosis (AIS) within other risk factors. Materials and Methods: We conducted a matched case–control study in adolescents aged 9–15 years. We matched the age and sex of adolescents with AIS to their healthy controls. The AIS is defined by a Cobb angle of 10° and the ligament hyperlaxity is defined by a Beighton score ≥4. The two parameters were identified blindly. Other risk factors for AIS were analyzed. The multivariate analysis by simple logistic regression was carried out. Results: We analyzed 430 adolescents, among them 215 subjects with AIS were paired with 215 healthy controls. The sex ratio (female/male) is 1.46. Scoliotics showed a significantly higher rate of joint hyperlaxity than controls, P < 0.003 (61.4% vs. 46.5%) with an odds ratio (Orb) of 1.83 confidence interval (CI) (1.25–2.68). The multivariate analysis by logistic regression revealed three predictors of AIS which are ligament hyperlaxity ORa = 1.82 CI (1.23–2.69) P < 0.003, the existence of similar cases in the ORa family = 1.94 (1.24–3.03) P < 0.002 and a trunk growth spurt ≥4 cm/6 months ORa = 1.62 (1.09–2.4) P < 0.02. Conclusion: There is a potential relationship between ligament hyperlaxity and the occurrence of idiopathic scoliosis in adolescents. Two other predictors were detected, similar cases of scoliosis in the family and the trunk growth spurt.
Background: The objective of our study is to investigate the relationship between ligament hyperlaxity and adolescent idiopathic scoliosis (AIS) within other risk factors. Materials and Methods: We conducted a matched case–control study in adolescents aged 9–15 years. We matched the age and sex of adolescents with AIS to their healthy controls. The AIS is defined by a Cobb angle of 10° and the ligament hyperlaxity is defined by a Beighton score ≥4. The two parameters were identified blindly. Other risk factors for AIS were analyzed. The multivariate analysis by simple logistic regression was carried out. Results: We analyzed 430 adolescents, among them 215 subjects with AIS were paired with 215 healthy controls. The sex ratio (female/male) is 1.46. Scoliotics showed a significantly higher rate of joint hyperlaxity than controls, P < 0.003 (61.4% vs. 46.5%) with an odds ratio (Orb) of 1.83 confidence interval (CI) (1.25–2.68). The multivariate analysis by logistic regression revealed three predictors of AIS which are ligament hyperlaxity ORa = 1.82 CI (1.23–2.69) P < 0.003, the existence of similar cases in the ORa family = 1.94 (1.24–3.03) P < 0.002 and a trunk growth spurt ≥4 cm/6 months ORa = 1.62 (1.09–2.4) P < 0.02. Conclusion: There is a potential relationship between ligament hyperlaxity and the occurrence of idiopathic scoliosis in adolescents. Two other predictors were detected, similar cases of scoliosis in the family and the trunk growth spurt.
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