Hyperlipidemia After Renal Transplantation in Children

Saldanha, Leopoldo F.

doi:10.1001/archpedi.1976.02120100041006

Cited by 16 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After kidney Tx, hyperlipidemia has been reported in up to 66% of children who did not receive CsA, suggesting a role for prednisone [11,16,17,18,19]. Saldanha et al [16] showed that TG (but not TC) was lower in Tx recipients on alternate-day (versus daily) prednisone. Saldanha et al [16] showed that TG (but not TC) was lower in Tx recipients on alternate-day (versus daily) prednisone.…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine

2003

View full text Add to dashboard Cite

Hyperlipidemia is a risk factor for cardiovascular disease in adult kidney transplant (Tx) recipients. We sought to determine the prevalence of, and the risk factors associated with, hyperlipidemia in pediatric kidney Tx recipients on cyclosporine (CsA). We identified 59 patients (mean age 8.2±5.7 years) transplanted between 1 January 1991 and 31 December 1993. Pre Tx, 34% had elevated total cholesterol [TC >200 mg/dl (5.17 mmol/l)]; 54% had elevated triglycerides [TG >200 mg/dl (2.26 mmol/L)]. Mean TG was higher pre Tx in dialysis (versus nondialysis) patients: 306 mg/dl (3.46 mmol/l) versus 228 mg/dl (2.58 mmol/l) (P=0.04). Mean TC was higher in peritoneal dialysis than hemodialysis patients: 222 mg/dl (5.74 mmol/l) versus 169 mg/dl (4.37 mmol/l) (P=0.03). Pre Tx and 3-year values correlated (TC, r=0.49, P=0.0008; TG, r=0.41, P=0.001); 3-and 5-year TC values correlated (r=0.57, P=0.003). At 5 years post Tx, 41% of the recipients had elevated TC; 14% had elevated TG. Recipients with elevated TC had higher mean CsA concentrations at 1 year post Tx (P=0.03). Recipients with elevated TG tended to receive more prednisone (P=0.06). At 5 years post Tx, recipients had a high prevalence of hyperlipidemia. The identification and treatment of hyperlipidemia should be included in pediatric kidney Tx protocols.

show abstract

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine

2003

View full text Add to dashboard Cite

show abstract

“…Obesity in adult renal transplant recipients is clearly a risk factor for hyperlipidemia [5,15,20]. We chose to use BMI, since our patients were all of pediatric age when body weight can only be properly assessed in conjunction with height.…”

Section: Discussionmentioning

confidence: 99%

“…However a few studies have investigated the incidence of post-renal transplant hyperlipidemia in pediatric patients. Some have shown that in children risk factors for hyperlipidemia include the use of prednisone and cyclosporine [13,15]. However, Sharma et al [16] demonstrated that cyclosporine was not a risk factor for hyperlipidemia in 33 pediatric patients several years after transplantation.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for hyperlipidemia in long-term pediatric renal transplant recipients

Silverstein

Palmer

Polinsky

et al. 2000

Pediatric Nephrology

View full text Add to dashboard Cite

Hyperlipidemia (HL) is a common problem in adult renal transplant (TP) recipients, contributing to an increased risk of cardiovascular disease and chronic TP nephropathy. There are multiple causes of HL post renal TP in adult patients, including pre TP HL, immunosuppressive agents, renal dysfunction, hypoalbuminemia secondary to nephrotic syndrome, obesity, and conditions that lead to end-stage renal disease (ESRD). We evaluated the incidence and risk factors of HL in 62 pediatric renal TP recipients (15.4+/-4.2 years, range-3.0-22.3 years) with long-term (6.7+/-3.1 years) functioning [glomerular filtration rate (GFR) 66.7+/-23.2 ml/min per 1.73 m(2)] allografts. The mean serum cholesterol (C) level was 205. 5+/-43.6 mg/dl. Thirty-two patients (51.6%) exhibited elevated serum C levels. The mean serum triglyceride (TG) level was 157.3+/-88.4 mg/dl. Serum TG levels were elevated in 32 patients (51.6%). In patients with elevated serum levels of either C or TG, the mean low-density lipoprotein level (LDL) was 138.6+/-44.1 mg/dl (normal <130 mg/dl) and the high-density lipoprotein (HDL) level 54.6+/-15.9 mg/dl (normal>34 mg/dl). Of those patients studied, 45.5% had high LDL levels, whereas 9.1% exhibited low HDL levels. The two risk factors for elevated serum C levels in our patient population were pre-TP HL and increased years since TP. The only risk factor for elevated serum TG levels was reduced GFR. A family history of HL had a significant deleterious impact upon serum levels of C (P=0.01), but did not affect serum TG levels (P=0.7). Years on dialysis prior to TP, history of prior TP, gender, body mass index, and disease leading to ESRD had no influence upon the development of post-TP HL. We conclude that post-renal TP HL is a significant problem in pediatric renal TP recipients.

show abstract

“…A comparison with results obtained in two studies [3,5] of children with kidney graft was difficult, since these investigations did not refer to homogenous age groups similar to ours, and since the different types of hyperlip idemia were not considered separately.…”

Section: Discussionmentioning

confidence: 67%

Plasma Lipids, Lipoproteins and Apolipoproteins AI, All, and B in Renal Transplanted Children: What Risk for Accelerated Atherosclerosis?

Goldstein¹,

Duhamel²,

Laudat³

et al. 1984

Nephron

View full text Add to dashboard Cite

The aim of the study was to investigate the atherosclerosis risk factors related to hyperlipidemia in renal transplanted children. Plasma cholesterol, triglycerides, apolipoproteins (Apo) AI, All and B, and the major lipoprotein classes separated by gradient ultracentrifugation were compared in 30 renal transplanted patients and 14 healthy children. Hyperlipidemia was present in 66% of the transplanted children. ‘Positive’ risk factors for atherosclerosis (high plasma cholesterol and Apo B) were present in hypercholesterolemic and combined hyperlipidemic subgroups. All transplanted children, whether normo- or hyperlipidemic, presented essentially ‘negative’ risk factors for atherosclerosis, i.e. significantly higher levels of Apo AI and All in plasma and in high-density lipoprotein HDL₂ and higher Apo AI/Apo B and/or Apo AII/B ratios. Repeated evaluations (over a 12-month period) in transplanted children indicated relatively frequent individual changes in the lipid pattern, but not in Apo AI and All content. These results suggest that the risks for accelerated atherosclerosis related to hyperlipidemia may be considered as moderate in transplanted children.

show abstract

Hyperlipidemia After Renal Transplantation in Children

Cited by 16 publications

References 9 publications

Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine

Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine

Risk factors for hyperlipidemia in long-term pediatric renal transplant recipients

Plasma Lipids, Lipoproteins and Apolipoproteins AI, All, and B in Renal Transplanted Children: What Risk for Accelerated Atherosclerosis?

Contact Info

Product

Resources

About