Hyperlipidemia as a Risk Factor for Cardiovascular Disease

Nelson, Robert H.

doi:10.1016/j.pop.2012.11.003

Cited by 883 publications

(626 citation statements)

References 43 publications

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“…PJK terutama disebabkan oleh aterosklerosis (Napoli et al, 2012) di mana salah satu faktor penyebabnya adalah hiperkolesterolemia (Nelson, 2013dan Murray et al 2003 akibat peningkatan Low density lipoprotein cholesterol (LDL-C) di dalam darah (Napoli et al, 2012). Hiperkolesterolemia dapat dihubungkan dengan salah satu efek utama akibat kurangnya insulin pada penderita diabetes melitus (Guyton dan Hall, 1997:1235.…”

Section: Pendahuluanunclassified

POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

Agnesa¹,

Waluyo

Prihatin

et al. 2017

Bioeksperimen

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Abstrak-Penyakit jantung koroner (PJK) terutama disebabkan oleh aterosklerosis karena hiperkolesterolimia. Oksidasi low density lipoprotein (LDL) oleh reactive oxygen species (ROS) sebagai penyebab utama proses aterogenik dapat dicegah dengan kehadiran antioksidan seperti vitamin E. Buah dan sayuran banyak mengandung vitamin. Salah satu buah yang mengandung vitamin E adalah buah merah (Pandanus conoideus Lam.). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah merah terhadap kadar LDL darah pada tikus putih (Rattus norvegicus L.). Jenis penelitian ini adalah penelitian eksperimental laboratorium yang didesain mengikuti Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 4 kali ulangan dengan parameter penelitian adalah kadar LDL darah tikus putih. Data dianalisis menggunakan one way anova dilanjutkan dengan uji Duncan 95%. Berdasarkan hasil penelitian, minyak buah merah memiliki kemampuan untuk menurunkan kadar LDL darah tikus putih.Kata Kunci: minyak buah merah, aterosklerosis, LDL.

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Section: Pendahuluanunclassified

POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

Agnesa¹,

Waluyo

Prihatin

et al. 2017

Bioeksperimen

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“…The extract seemed to be more effective in reducing triacylglycerol, total cholesterol and VLDL; and increasing HDL than in reducing LDL in normoglycemic condition. Hyperlipidemia associated with lipid disorders are considered to cause atherosclerotic cardiovascular disease [25]. Interestingly, the plant extract may be highly beneficial in preventing the development of atherosclerotic plague formation considering its lipid lowering potentials especially in normal rats.…”

Section: Resultsmentioning

confidence: 99%

Sub-chronic Effect of Methanol-Dichloromethane Stem Bark Extract of Stemonocoleus micranthus Harms. (Fabaceae) on Lipid Profile and Histology of Liver and Kidney of Rats

Mbaoji¹,

Ezike²,

Nworu³

et al. 2017

J Pharmacogn Nat Prod

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In Nigerian ethnomedicine, Stemonocoleus micranthus Harms (Fabaceae) is used in the management of heart related diseases. This study investigated the effect of sub-chronic administration of methanol-dichloromethane stem bark extract of S. micranthus (SME) on lipid profile and histology of liver and kidney of rats. Adult albino rats of both sexes were randomly divided into four groups (n=5) and received daily administration of SME (100, 200, and 400 mg/kg) and 2 ml/kg distilled water (control) respectively for 28 days per oral. Biochemical tests were performed pretreatment and subsequently fortnightly as the treatment commenced. The results showed that the extract increased the serum high density lipoprotein cholesterol concentration while low density lipoprotein cholesterol, total cholesterol, triacylglycerol, and very low density lipoprotein cholesterol concentrations were reduced compared with the baseline values. However, the histopathological examination of the liver and kidney of the rats that received extract and solvent revealed normal portal area with bile ducts and hepatic artery as well as normal glomerulus and renal tubules without observable changes suggesting zero tendency of causing toxic effects. The preliminary phytochemical analysis showed that SME contained alkaloids, glycosides, flavonoids, reducing sugars, terpenoids, saponins, proteins and, fats oils. SME exhibited an oral LD 50 >5 g/kg in mice. These findings suggest that the stem bark extract of S. micranthus contains constituents that possess hypolipidemic activity in rats.

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“…Tingginya proporsi masyarakat lanjut usia di Dusun Mergan membutuhkan perhatian tersendiri terutama karena orang lanjut usia secara fisiologis mengalami penurunan fungsi organ yang meningkatkan risiko morbiditas penyakit degeneratif (Lunenfeld and Stratton, 2013 Hasil wawancara pada beberapa peserta kegiatan ini menunjukkan tingginya konsumsi makanan yang mengandung kolesterol serta rendahnya aktivitas fisik dapat menjadi penyebab tidak terkontrolnya kadar kolesterol. Tingginya kadar kolesterol merupakan salah satu risiko besar untuk penyakit kardiovaskular (Nelson, 2013).…”

Section: Hasil Dan Pembahasan Kegiatan Penyuluhan Kesehatanunclassified

Peran Apoteker dalam Pengelolaan Penyakit Degeneratif di Dusun Mergan Sendangmulyo, Sleman, D.I. Yogyakarya

Virginia

Widayati

2018

ALTRUIS

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Findings of the preliminary survey showed a high proportion of geriatric people in Dusun Mergan, Sendangmulyo, Sleman, which leads to high risk of cardiovascular and other degenerative diseases. This community service program aimed to identify the health status of Mergan's people through health screening and to help them to maintain their health. This program was conducted in collaboration between the Faculty members and students of Pharmacy Faculty of Universitas Sanata Dharma Yogyakarta (USD). There were two consecutive periods; the first was in 7th of May and the second was in 22nd of October 2018. Health education, health screening, and health examination were conducted in each period. There were 93 people involved in the first period and 64 people in the second; however, only 32 persons who completely attended the two meeting periods. The program resulted data of 60.7% Mergan's people with a risk of dyslipidemia, and 59.0% with hyperglycemic. There was no significant difference between the first and the second periods of examination of glucose level, cholesterol, and uric acid. Therefore, it is urgent to educate people in Mergan Village to promote and maintain a healthy lifestyle in order to decrease morbidity of degenerative disease in the community.

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Hyperlipidemia as a Risk Factor for Cardiovascular Disease

Cited by 883 publications

References 43 publications

POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

Sub-chronic Effect of Methanol-Dichloromethane Stem Bark Extract of Stemonocoleus micranthus Harms. (Fabaceae) on Lipid Profile and Histology of Liver and Kidney of Rats

Peran Apoteker dalam Pengelolaan Penyakit Degeneratif di Dusun Mergan Sendangmulyo, Sleman, D.I. Yogyakarya

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