Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins

Fang, William; Bonavida, Victor; Agrawal, Devendra K.; Thankam, Finosh G.

doi:10.1007/s00441-023-03748-8

Cited by 11 publications

(3 citation statements)

References 84 publications

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“…The difference in water content of the tendon tissues of hyperlipidemic group (74.02±5.72 w/w) and control swines (67.62±3.47 w/w) were not significant. Hyperlipidemia increases the proteoglycan content, vascularity and hence increases the water content in tendons [ 25 ]. Previous studies state that hyperlipidemia alters the native ECM composition of the tendons and hence affecting the biomechanical properties of the tendons [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

Lal L.P,

K. Agrawal

2024

J Ortho Sports Med

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Hyperlipidemia is linked to atherosclerosis and various diseases. Its strong association with Achilles tendinopathies and xanthomas affects tendon properties through lipid deposition in tendon tissue. We examined the impact of hyperlipidemia on the biomechanical properties of the swine Achilles tendons. Swines were fed a high-cholesterol-high-fat diet to induce hyperlipidemia, and their Achilles tendons were collected and examined for biomechanical properties. The ultimate tensile strength, modulus of elasticity and viscoelastic properties did not exhibit significant differences between hyperlipidemic and control swines. H&E and pentachrome staining revealed extracellular matrix (ECM) disorganization and cellular infiltration in the hyperlipidemic swines, highlighting a marked difference between the control and hyperlipidemic groups. These results suggest hyperlipidemia in young swines alters the tendon composition and may contribute to weak biomechanical properties with time.

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Section: Discussionmentioning

confidence: 99%

Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

Lal L.P,

K. Agrawal

2024

J Ortho Sports Med

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“…In the tendon, GAGs, glycoproteins, proteoglycans, as well as smaller molecules serve distinct roles. They reduce tissue distortion, contribute viscoelasticity, work as lubricants, and offer ECM integrity by occupying intrafibrillar space and avoiding collapse, among several other activities ( Fang et al, 2023 ).…”

Section: Tendon Structure and Mechanical Characteristicsmentioning

confidence: 99%

An overview of the material science and knowledge of nanomedicine, bioscaffolds, and tissue engineering for tendon restoration

Liang

Zhou

Meng

et al. 2023

Front. Bioeng. Biotechnol.

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Tendon wounds are a worldwide health issue affecting millions of people annually. Due to the characteristics of tendons, their natural restoration is a complicated and lengthy process. With the advancement of bioengineering, biomaterials, and cell biology, a new science, tissue engineering, has developed. In this field, numerous ways have been offered. As increasingly intricate and natural structures resembling tendons are produced, the results are encouraging. This study highlights the nature of the tendon and the standard cures that have thus far been utilized. Then, a comparison is made between the many tendon tissue engineering methodologies proposed to date, concentrating on the ingredients required to gain the structures that enable appropriate tendon renewal: cells, growth factors, scaffolds, and scaffold formation methods. The analysis of all these factors enables a global understanding of the impact of each component employed in tendon restoration, thereby shedding light on potential future approaches involving the creation of novel combinations of materials, cells, designs, and bioactive molecules for the restoration of a functional tendon.

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“…As foam cells proliferate and a persistent inflammatory response, the AS plaque is developed. With further progression, these plaques (particularly the vulnerable ones) undergo rupture, ultimately resulting in the formation of acute coronary syndromes. − …”

Section: Introductionmentioning

confidence: 99%

Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy

Xiao,

Xu,

Liu

et al. 2024

Biomacromolecules

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Atherosclerosis (AS) is characterized by the accumulation of substantial low-density lipoprotein (LDL) and inflammatory response. Hemoperfusion is commonly employed for the selective removal of LDL from the body. However, conventional hemoperfusion merely focuses on LDL removal and does not address the symptom of plaque associated with AS. Based on the LDL binding properties of acrylated chondroitin sodium sulfate (CSA), acrylated beta-cyclodextrin (CD) and acrylic acid (AA), along with the anti-inflammatory property of rosiglitazone (R), the fabricated AA-CSA-CD-R microspheres could simultaneously release R and facilitate LDL removal for hemoperfusion. The AA and CSA offer electrostatic adsorption sites for LDL, while the CD provides hydrophobic adsorption sites for LDL and weak binding sites for R. According to the Sips model, the maximum static LDL adsorption capacity of AA-CSA-CD-R is determined to be 614.73 mg/g. In dynamic simulated perfusion experiments, AA-CSA-CD-R exhibits an initial cycle LDL adsorption capacity of 150.97 mg/g. The study suggests that the weakened inflammatory response favors plaque stabilization. The anti-inflammatory property of the microspheres is verified through an inflammation model, wherein the microsphere extracts are cocultured with mouse macrophages. Both qualitative analysis of iNOS\TNF-α and quantitative analysis of IL-6\TNF-α collectively demonstrate the remarkable anti-inflammatory effect of the microspheres. Therefore, the current study presents a novel blood purification treatment of eliminating pathogenic factors and introducing therapeutic factors to stabilize AS plaque.

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Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins

Cited by 11 publications

References 84 publications

Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

An overview of the material science and knowledge of nanomedicine, bioscaffolds, and tissue engineering for tendon restoration

Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy

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