Hyperlipidemia Is a Risk Factor for Decreased Cerebral Perfusion and Stroke

Meyer, John Stirling; Rogers, Robert L.; Mortel, Karl F.; Judd, Brian W.

doi:10.1001/archneur.1987.00520160052014

Cited by 48 publications

(26 citation statements)

References 26 publications

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“…For example, lower CBF values were found in patients with transient ischemic attacks and hypercholesterolemia from all causes compared with matched control subjects with normal cholesterol concentrations. 12 However, the majority of such patients were also affected by other common vascular risk factors, such as hypertension, and consequently significant interactions among multiple risk factors on cerebral circulation could not be ruled out. Moreover, in the same study normal subjects with hypercholesterolemia did not show significantly lower CBF in comparison to normolipemic control subjects, although the authors ascribed this result to the small number of cases studied.…”

Section: Discussionmentioning

confidence: 99%

Regional cerebral blood flow in familial hypercholesterolemia.

Rodriguez

Bertolini

Nobili

et al. 1994

Stroke

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Section: Discussionmentioning

confidence: 99%

Regional cerebral blood flow in familial hypercholesterolemia.

Rodriguez

Bertolini

Nobili

et al. 1994

Stroke

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“…3 Hypertension has been shown to be an important risk factor for reduced CBF among neurologically normal volunteers 10 and among patients with transient ischemic attacks. 11 An autopsy study in Hisayama, Japan, 12 has shown that cerebral atherosclerosis occurs 20-30 years earlier in hypertensive than in normotensive patients. In stroke-prone spontane- ously hypertensive rats, it was suggested that thickening of the arterial wall at the terminal stage of severe hypertension caused an irreversible and severe decrease in rCBF.…”

Section: Discussionmentioning

confidence: 99%

Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits.

Fujii

Sadoshima

Okada

et al. 1990

Stroke

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We used positron emission tomography to examine retrospectively the effects of blood pressure on regional cerebral blood flow and oxygen metabolism in seven normotensive and eight hypertensive patients with a history of transient neurologic deficits. In the hypertensive patients, a decrease in regional cerebral blood flow was closely related to blood pressure; these changes were most pronounced in the supratentorial structures, especially the striatum and thalamus. In contrast, the regional cerebral metabolic rate for oxygen was less related to blood pressure. Consequently, the regional oxygen extraction fraction was increased in the hypertensive patients, while regional cerebral blood volume and the regional cerebral blood flow: volume ratio were unchanged. Multivariate regression analysis confirmed that hypertension was an independent factor affecting regional cerebral blood flow. The analysis also disclosed that age, sex, hematocrit, smoking, and Paco 2 affected regional cerebral blood flow. These findings suggest that the hemodynamic reserve in hypertensive individuals is reduced, which may predispose them to cerebral ischemia and perhaps stroke, even during small decreases in cerebral perfusion pressure. (Stroke 1990^1:283-290)

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“…Thus, irradiation-induced vascular damage and the resulting hypoperfusion and cognitive decline can be exacerbated by coexisting hypertension, diabetes, smoking and hyperlipidemia. H owever, there is evidence for reversibility of the pathophysiological alterations linked to cigarette smoking, hypertension, diabetes, and hyperlipidemia (53)(54)(55). Cross-sectional studies of cerebral blood ow have shown that cerebral perfusion levels improve following cessation of smoking (54).…”

Section: Preventionmentioning

confidence: 99%