Hypermagnesemia and feeding intolerance in preterm infants: A cohort study

Junqueira, Elibene Orro; Caldas, Jamil Pedro de Siqueira; Marba, Sérgio Tadeu Martins

doi:10.1002/jpen.2336

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…There are reports that it influences the transition to full enteral feeding and is associated with delayed feeding tolerance (24,25). It has been revealed that the serum magnesium concentration of newborns applied antenatal MgSO4 is higher than normal during the first 72 hours of life, especially in premature infants, and that this situation was linked to feeding intolerance (26). In our study, antenatal magnesium prophylaxis was found to be significantly associated with an increased risk of feeding intolerance.…”

Section: Discussionsupporting

confidence: 48%

The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems

Sınacı

Şimşek

Sakcak

et al. 2023

Gynecol Obstet Reprod Med

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OBJECTIVE: Obstetric problems have detrimental effects on both pregnancy and newborn. We aimed to examine the relationship between pregnancy complications and newborn morbidities. STUDY DESIGN: The newborns admitted to the neonatal intensive care unit between September 2019 and August 2022 were included in this retrospective cross-sectional study. Antenatal morbidities and neonatal complications including low APGAR-score (<5), bronchopulmonary dysplasia, early neonatal sepsis, and early neonatal death were evaluated. Pearson-χ2 cross-tabs were used to compare two variables. A p-value <0.05 was determined statistically significant. RESULTS: Among the 686 infants analyzed, 94 (13.7%) had early neonatal death, 264 (38.5%) had bronchopulmonary dysplasia, 259 (37.8%) had early neonatal sepsis, and 424 (61.9%) had feeding intolerance. Early neonatal sepsis was observed significantly higher in newborns whose mothers had urinary tract infection in the last two weeks (p<0.001), preterm premature rupture of membranes (p=0.006), or clinical chorioamnionitis (p<0.001). Early neonatal death was found significantly higher in pregnancies with preeclampsia (p<0.001), preterm premature rupture of membranes (p<0.001), clinical chorioamnionitis (p<0.001), or small-for-gestational-age (p<0.001). Preeclampsia and magnesium neuroprophylaxis were found significantly higher in neonates with feeding intolerance (p<0.001). Backward: LR logistic regression analysis based on early neonatal sepsis risk revealed that birth week, preterm premature rupture of membranes, clinical chorioamnionitis, small-for-gestational-age, and urinary tract infection were significant parameters affecting the risk of early neonatal sepsis (p<0.05). CONCLUSION: Preventing premature births and cautious management of pregnancy complications may be helpful in reducing adverse neonatal outcomes. Early detection of high-risk pregnancies and transfer to a tertiary center may be helpful to improve neonatal outcomes.

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Section: Discussionsupporting

confidence: 48%

The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems

Sınacı

Şimşek

Sakcak

et al. 2023

Gynecol Obstet Reprod Med

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Hypermagnesiämie ist mit früher Fütterungsintoleranz assoziiert

2022

Neonatologie Scan

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Association of hypermagnesemia at birth and admission hypothermia in pre-term infants: A secondary analysis of a prospective cohort study

Caldas,

Junqueira,

de Camargo

et al. 2024

NPM

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BACKGROUND: Hypothermia on admission is associated with increased mortality in preterm infants. Drugs administered to pregnant women is implicated in its occurrence. Since magnesium sulfate has a myorelaxant effect, we aimed evaluating the association of hypermagnesemia at birth and admission hypothermia (axillary temperature <36.5°C) in preterm infants. METHODS: We performed a secondary analysis of a prospective cohort study database including inborn infants <34 weeks, without congenital malformations. Hypermagnesemia was considered if the umbilical magnesium level > 2.5 mEq/L. Maternal and neonatal variables were used to adjust the model, submitted to the multivariate hierarchical modelling process. RESULTS: We evaluated 249 newborns with median birth weight and gestational age of 1375 (IQR 1020–1375) g and 31 (IQR 28–32) weeks, respectively. Hypermagnesemia occurred in 28.5% and admission hypothermia occurred in 28.9% . In the univariate analysis, the following variables were identified as being associated with admission hypothermia: hypermagnesemia (OR 3.71; CI 2.06–6.68), resuscitation (OR 2.39; CI 1.37–4.19), small to gestational age (OR 1.91; CI1.03–3.53), general anesthesia (OR 3.34; CI 1.37–8.13), birth weight (OR 0.998; CI 0.998–0.999) and gestational age (OR 0.806; CI 0.725–0.895). In the hierarchical regression model, hypermagnesemia remained independent associated with admission hypothermia (OR 3.20; CI 1.66–6.15), as well as birth weight (OR 0.999; CI 0.998–0.999) and tracheal intubation (3.83; CI 1.88–7.80). CONCLUSION: Hypermagnesemia was associated with an increased risk of admission hypothermia, as did tracheal intubation and lower birth weight.

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Hypermagnesemia and feeding intolerance in preterm infants: A cohort study

Cited by 4 publications

References 39 publications

The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems

The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems

Hypermagnesiämie ist mit früher Fütterungsintoleranz assoziiert

Association of hypermagnesemia at birth and admission hypothermia in pre-term infants: A secondary analysis of a prospective cohort study

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