Hypermethylation and low expression of FANCC involved in multi-walled carbon nanotube-induced toxicity on ARPE-19 cells

Liang, Yunxia; Zhou, Yang; Xie, Dongli; Yin, Fei; Luo, Xiaogang

doi:10.1016/j.envres.2023.117619

Cited by 1 publication

(3 citation statements)

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“…On the other hand, Liang et al identified that MWCNT exposure was observed to cause damages to the viability of ocular cells; however, the underlying mechanisms remain not well-understood. This study provides the first evidence that DNA hypermethylation in the promoter (cg14583550) and downregulated expression of FANCC gene may be underlying mechanisms associated with MWCNT-induced retinal toxicity …”

Section: Risks and Effects Of Cntsmentioning

confidence: 86%

“…Toxicological data were obtained from testing on healthy animals, and the data revealed that PEG-MWCNTs did not induce an important toxicity profile. Considering all the results obtained 189 Due to the variation in structure, size, and chemical surfaces among SWCNTs and MWCNTs 190 the solubilizing agents also have an imperative part in the toxicity of CNTs. In natural dispersants, individual CNTs tend to bundle, which leads to toxicity.…”

Section: Risks and Effects Of Cntsmentioning

confidence: 94%

“…This study provides the first evidence that DNA hypermethylation in the promoter (cg14583550) and downregulated expression of FANCC gene may be underlying mechanisms associated with MWCNT-induced retinal toxicity. 189 Due to the variation in structure, size, and chemical surfaces among SWCNTs and MWCNTs 190 the solubilizing agents also have an imperative part in the toxicity of CNTs. In natural dispersants, individual CNTs tend to bundle, which leads to toxicity.…”

Section: Risks and Effects Of Cntsmentioning

confidence: 99%

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A Review on Carbon Nanotubes Family of Nanomaterials and Their Health Field

Brito,

Silva,

Gonzaga

et al. 2024

ACS Omega

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The use of carbon nanotubes (CNTs), which are nanometric materials, in pathogen detection, protection of environments, food safety, and in the diagnosis and treatment of diseases, as efficient drug delivery systems, is relevant for the improvement and advancement of pharmacological profiles of many molecules employed in therapeutics and in tissue bioengineering. It has contributed to the advancement of science due to the development of new tools and devices in the field of medicine. CNTs have versatile mechanical, physical, and chemical properties, in addition to their great potential for association with other materials to contribute to applications in different fields of medicine. As, for example, photothermal therapy, due to the ability to convert infrared light into heat, in tissue engineering, due to the mechanical resistance, flexibility, elasticity, and low density, in addition to many other possible applications, and as biomarkers, where the electronic and optics properties enable the transduction of their signals. This review aims to describe the state of the art and the perspectives and challenges of applying CNTs in the medical field. A systematic search was carried out in the indexes Medline, Lilacs, SciELO, and Web of Science using the descriptors "carbon nanotubes", "tissue regeneration", "electrical interface (biosensors and chemical sensors)", "photosensitizers", "photothermal", "drug delivery", "biocompatibility" and "nanotechnology", and "Prodrug design" and appropriately grouped. The literature reviewed showed great applicability, but more studies are needed regarding the biocompatibility of CNTs. The data obtained point to the need for standardized studies on the applications and interactions of these nanostructures with biological systems.

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Section: Risks and Effects Of Cntsmentioning

confidence: 86%

Section: Risks and Effects Of Cntsmentioning

confidence: 94%

Section: Risks and Effects Of Cntsmentioning

confidence: 99%

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