Hyperocclusion stimulates the expression of collagen type XII in periodontal ligament

Tsuzuki, Takashi; Kajiya, Hiroshi; T-Goto, Kazuko; Tsutsumi, Takashi; Nemoto, Tetsuomi; Okabe, Koji; Takahashi, Yutaka

doi:10.1016/j.archoralbio.2016.02.009

Cited by 15 publications

(11 citation statements)

References 30 publications

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“…Another model of hyperloading involves the creation of premature occlusal contact, which triggers a robust catabolic reaction (Walker et al 2008;Goto et al 2011;Tsutsumi et al 2013;Tsuzuki et al 2016;Tsutsumi et al 2018). Unlike our study, however, a subsequent anabolic response (Figs.…”

Section: Discussionmentioning

confidence: 57%

Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt

Yuan

Zhang

et al. 2019

J Dent Res

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Despite an extensive literature documenting the adaptive changes of bones and ligaments to mechanical forces, our understanding of how tissues actually mount a coordinated response to physical loading is astonishingly inadequate. Here, using finite element (FE) modeling and an in vivo murine model, we demonstrate the stress distributions within the periodontal ligament (PDL) caused by occlusal hyperloading. In direct response, a spatially restricted pattern of apoptosis is triggered in the stressed PDL, the temporal peak of which is coordinated with a spatially restricted burst in PDL cell proliferation. This culminates in increased collagen deposition and a thicker, stiffer PDL that is adapted to its new hyperloading status. Meanwhile, in the adjacent alveolar bone, hyperloading activates bone resorption, the peak of which is followed by a bone formation phase, leading ultimately to an accelerated rate of mineral apposition and an increase in alveolar bone density. All of these adaptive responses are orchestrated by a population of Wnt-responsive stem/progenitor cells residing in the PDL and bone, whose death and revival are ultimately responsible for directly giving rise to new PDL fibers and new bone.

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Section: Discussionmentioning

confidence: 57%

Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt

Yuan

Zhang

et al. 2019

J Dent Res

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“…Biomechanically, the PDL is a soft biological tissue that can be considered a porous vasculature solid with a highly structured collagen network . Approximately 50% to 75% of the PDL volume is formed by collagen fibres, primarily type I, III, and XII fibres (Figure B) . The fibres are primarily responsible for the differences observed in PDL reactions under tensile force.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] Approximately 50% to 75% of the PDL volume is formed by collagen fibres, 7 primarily type I, 7 III, 8 and XII fibres ( Figure 1B). 9 The fibres are primarily responsible for the differences observed in PDL reactions under tensile force. On the other hand, the high vascular density of the PDL confers the tissue a viscoelastic behaviour, which has been extensively studied in the literature.…”

Section: Introductionmentioning

confidence: 99%

A porous fibrous hyperelastic damage model for human periodontal ligament: Application of a microcomputerized tomography finite element model

Ortún‐Terrazas

Cegoñino

Santana‐Penín

et al. 2019

Numer Methods Biomed Eng

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The periodontal ligament (PDL) is a soft biological tissue that connects the tooth with the trabecular bone of the mandible. It plays a key role in load transmission and is primarily responsible for bone resorption and most common periodontal diseases. Although several numerical studies have analysed the biomechanical response of the PDL, most did not consider its porous fibrous structure, and only a few analysed damage to the PDL. This study presents an innovative numerical formulation of a porous fibrous hyperelastic damage material model for the PDL. The model considers two separate softening phenomena: fibre alignment during loading and fibre rupture. The parameters for the material model characterization were fitted using experimental data from the literature. Furthermore, the experimental tests used for characterization were computationally modelled to verify the material parameters. A finite element model of a portion of a human mandible, obtained by microcomputerized tomography, was developed, and the proposed constitutive model was implemented for the PDL. Our results confirm that damage to the PDL may occur mainly because of overpressure of the interstitial fluid, while large forces must be applied to damage the PDL fibrous network. Moreover, this study clarifies some aspects of the relationship between PDL damage and the bone remodelling process.

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“…The timing of protein expression and the localization of collagens XIIa and XIVa have been investigated in the periodontal ligament (PDL; Zhang et al, 1993 ; Tsuzuki et al, 2016 ), but neither in the developing tooth nor in the alveolar bone. For this reason, a specific study was designed covering prenatal as well as postnatal stages in mouse first lower molar and periodontium from embryonic day 13 (E13), when the forming alveolar bone becomes morphologically apparent around the molar tooth bud, until postnatal day 22 (P22), as the posteruption stage, when the tooth is dynamically anchored.…”

Section: Introductionmentioning

confidence: 99%

Regulators of Collagen Fibrillogenesis during Molar Development in the Mouse

2017

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Development of mammalian teeth and surrounding tissues includes time–space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small leucine-rich proteoglycans (SLRPs) are involved in the regulation of collagen fibrillogenesis. Recently, collagen type XII and collagen type XIV, members of the FACITs family, were found in the peridental mesenchyme contributing to alveolar bone formation. This study was designed to follow temporospatial expression of collagen types XIIa and XIVa in mouse first molar and adjacent tissues from embryonic day 13, when the alveolar bone becomes morphologically apparent around the molar tooth bud, until postnatal day 22, as the posteruption stage. The patterns of decorin, biglycan, and fibromodulin, all members of the SLRPs family and interacting with collagens XIIa and XIVa, were investigated simultaneously. The situation in the tooth was related to what happens in the alveolar bone, and both were compared to the periodontal ligament. The investigation provided a complex localization of the five antigens in soft tissues, the dental pulp, and periodontal ligaments; in the mineralized tissues, predentin/dentin and alveolar bone; and junction between soft and hard tissues. The results illustrated developmentally regulated and tissue-specific changes in the balance of the two FACITs and three SLRPs.

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Hyperocclusion stimulates the expression of collagen type XII in periodontal ligament

Cited by 15 publications

References 30 publications

Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt

Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt

A porous fibrous hyperelastic damage model for human periodontal ligament: Application of a microcomputerized tomography finite element model

Regulators of Collagen Fibrillogenesis during Molar Development in the Mouse

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