Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Abstract

Hyperoside (Hyp), also known as quercetin-3-O-galactoside or 3-O-β-D-galactopyranosyl, is a well-known flavonol glycoside that is abundant in various fruits, vegetables, and medicinal plants. Hyp has been suggested to exhibit a wide range of biological actions, including cardiovascular, renal, neuroprotective, antifungal, antifibrotic, and anticancer effects. Accumulating evidence supports the pharmacological activities of Hyp in improving liver pathophysiology. Hence, the present literature review aims to summarize preclinical data suggesting the beneficial effects and underlying mechanisms of Hyp. In addition, our study focuses on hepatic antioxidant defense signaling to assess the underlying mechanisms of the biological actions of Hyp that are closely associated with liver diseases. Experimental findings from an up-to-date search showed that Hyp possesses hepatoprotective, antiviral, antisteatotic, anti-inflammatory, antifibrotic, and anticancer activities in cellular and animal models related to liver dysfunction by enhancing antioxidant responses. In particular, hepatocellular antioxidant defense via activation of erythroid-related nuclear factor 2 by Hyp chiefly explains how this compound acts as a therapeutic agent in liver diseases. Thus, this review emphasizes the therapeutic potential of Hyp as a strong antioxidative substance that plays a crucial role in the regulation of various liver disorders during their pathogenesis.

Bridging the gap in antioxidant activity of flavonoids: Correlating the oxidation of human plasma with chemical and cellular assays

“…The antioxidant activity of HP is likely intricately linked to its chemical composition, primarily contingent upon the primary structure and positioning of the galactose sugar moiety attached to this compound. Its effectiveness is impacted by the presence of galactose at position C-3 and the β-hydroxyl groups at C-3′ and C-4′, highlighting the significance of the antioxidant structure–activity relationship ( Jang, 2022 ).…”

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

“…It has the potential to operate antioxidant activity to prevent hepatic oxidative stress in liver diseases. Te hydrogen peroxide-induced intracellular oxidative damage in HepG2 cell lines demonstrated the antioxidative efects of hyperoside [49]. Notably, in the presence of hyperoside, the modulation of hepatic mitogen-activated protein kinase, heme-oxygenase-1, nuclear factor erythroid 2-related factor 2, and may augment antiapoptosis and ultimately prevent chemically-driven hepatotoxicity in mice [50].…”

Exploring the Wound Healing Potential of a Cuscuta chinensis Extract-Loaded Nanoemulsion-Based Gel

“…Nevertheless, kaempferol and hyperoside were found in the DE. Previous research has reported that hyperoside exhibits a wide range of pharmacological effects, including antioxidant activity, anti-cancer activity, neuroprotective activity, antimicrobial activity, and anti-inflammatory activity [47,48]. It can decrease the intracellular reactive oxygen species (ROS) levels and lipid peroxidation in Saccharomyces cerevisiae [49].…”