Hyperosmolarity causes inflammation through the methylation of protein phosphatase 2A

Abolhassani, Mohsen; Wertz, Xavier; Pooya, Mohammad; Chaumet-Riffaud, Philippe; Guais, Adeline; Schwartz, Laurent

doi:10.1007/s00011-007-7213-0

Cited by 45 publications

(58 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to hyperosmotic shock (2,29), the toxicity of carbon dioxide is partly mediated by the activation of PP2A, which results in the translocation of NF-B. The mechanism of action of CO 2 might also involve the inhibition of the Krebs cycle and glycolysis for stoichiometric reasons.…”

Section: Discussionmentioning

confidence: 99%

“…Cytokine secretions into the supernatants of HT-29 and A549 human cells (cultivated in 25-cm 2 flask) were quantified after a 48-h culture using the DuoSet ELISA development kit (R&D Systems, Minneapolis, MN) for human IL-8, IL-6, and MCP-1, as already described (2).…”

Section: Methodsmentioning

confidence: 99%

“…It reacts with water to undergo hydration and release carbonic acid (CO 2 ϩ H 2 O 7 H 2 CO 3 7 H ϩ ϩ HCO 3 Ϫ ). As for other buffers, pH is related to concentrations of CO 2 and bicarbonates according to the Henderson-Hasselbalch equation. There are several reports in the literature suggesting that exposure to high concentrations of CO 2 can be deleterious.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Carbon dioxide inhalation causes pulmonary inflammation

Abolhassani¹,

Guais²,

Chaumet-Riffaud³

et al. 2009

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Carbon dioxide inhalation causes pulmonary inflammation

Abolhassani¹,

Guais²,

Chaumet-Riffaud³

et al. 2009

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

show abstract

“…Just as there is now considerable ONCOLOGY REPORTS 23: 1407-1416, 2010 A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results interest in the role of the glycolytic phenotype as a key target for the development of effective drugs for cancer, the inflammatory response has also been recognized as a potential target (12,13). Our laboratory has in the past few years investigated the role of hyperosmolarity as a cause of inflammation and its potential link to cancer (14)(15)(16) and most recently showed that the inhalation of carbon dioxide, a product of cellular respiration, was able to induce inflammation of the lung (17). As a consequence, focusing on metabolic changes involving glucose metabolism that characterize cancer cells appeared to us to be a logical extension of our work in the area of inflammation.…”

Section: Introductionmentioning

confidence: 99%

A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results

Schwartz¹

2010

Oncol Rep

View full text Add to dashboard Cite

Abstract. The impact of metabolic dysregulation on tumor development has long been established. We have targeted two enzymes that are altered during carcinogenesis: pyruvate dehydrogenase (PDH), which is down-regulated, and ATP citrate lyase, which is overexpressed in cancer cells. Alpha lipoic acid is a cofactor of PDH, while hydroxycitrate is a known inhibitor of ATP citrate lyase. Our hypothesis is that a combination of these drugs may have antitumoral potential. The efficacy of these molecules was screened in vitro by treatment of different human cancer and murine cell lines. Lipoic acid reduced the cell number by 10-50% depending on concentrations (0.1-10 μM) and cell types. Calcium hydroxycitrate reduced the cell number by 5-60% at different concentrations (10-500 μM). When hydroxycitrate and lipoic acid were used together, there was a major cytotoxic effect: complete cell death was seen following 8 μM lipoic acid and 300 μM hydroxycitrate treatment for 72 h. The combination of alpha lipoic acid and hydroxycitrate was administered to healthy mice, at doses currently utilized for other indications than cancer; no demonstrable toxicity was observed. The combination was used to treat mouse syngenic cancer models: MBT-2 bladder transitional cell carcinoma, B16-F10 melanoma and LL/2 Lewis lung carcinoma. The efficacy of this combination appears similar to conventional chemotherapy (cisplatin or 5-fluorouracil) as it resulted in significant tumor growth retardation and enhanced survival. This preliminary study suggests that this combination of drugs is efficient against cancer cell proliferation both in vitro and in vivo. A clinical trial is warranted.

show abstract

“…Extensive research and application history in Germany -Promotion of endogenous fat mobilization and oxidation [7] -Studies as an antiulcer agent [10] -Resuscitation from diabetic coma (early Japanese and German observations) -Prevention of adrenocortical suppression during steroid therapy [7] -Increase in auditory threshold values in patients with Ménière's disease [11,12] -Therapy of adenosine deaminase deficiency in a form of adult myopathy [13] -Therapy of glucose 6-phosphate dehydrogenase deficiency in red blood cells (anemia) [14] -Restoration of heart muscle adenine nucleotide levels [15] -Increase in the levels of retinol-binding proteins [7] -Reduction in the incidence of liver and bile duct disorders [7]; older literature shown in ref. [21] -Amelioration of drug-induced hemolysis [22] -Prevention of acute middle ear infections in infants [23][24][25] -Antibacterial effect on pneumococcal nasal colonization [26] -Alleviation of cystic fibrosis condition [27] -Stimulation of cytokine induction (rat bladder cell lines) [28] -Reconstitution of integral membrane transport proteins [29] -Skin care with farnesol (atopic dry skin; Staphylococcus aureus)…”

Section: The Chemical Profile Of Alditolsmentioning

confidence: 99%

Sugar Alcohol Sweeteners as Alternatives to Sugar with Special Consideration of Xylitol

Mäkinen¹

2011

Med Princ Pract

View full text Add to dashboard Cite

Introduction: Dental caries is a diet-associated disease which continues to be a serious health problem in most industrialized and developing countries. Strategies to maximize caries prevention should automatically consider the use of sugar substitutes. It is important that public health authorities are made cognizant of the availability of new polyol-type sugar substitutes. Review Summary: Clinical studies have shown that xylitol, a natural, physiologic sugar alcohol of the pentitol type, can be used as a safe and effective caries-limiting sweetener. Habitual use of xylitol-containing food and oral hygiene adjuvants has been shown to reduce the growth of dental plaque, to interfere with the growth of caries-associated bacteria, to decrease the incidence of dental caries, and to be associated with remineralization of caries lesions. Numerous public regulatory bodies have endorsed the use of xylitol as a caries-limiting agent. Other sugar alcohols that have been successfully used as sugar substitutes include D-glucitol (sorbitol), which, however, owing to its hexitol nature, normally has no strong effect on the mass and adhesiveness of bacterial plaque and on the growth of mutans streptococci. A tetritol-type alditol, erythritol, has shown potential as a non-cariogenic sugar substitute. Combinations of xylitol and erythritol may reduce the incidence of caries more effectively than either alditol alone. Conclusions: Partial sugar substitution with polyols is an important dietary tool in the prevention of dental caries that should be used to enhance existing fluoride-based caries prevention programmes. The most effective method of conveying this information to the public is through a proper health claim for these alditols in food labelling. The present review summarizes clinical and biochemical aspects of the above three dietary polyols and emphasizes the role of sugar substitution as a potential health-promoting strategy.

show abstract

Hyperosmolarity causes inflammation through the methylation of protein phosphatase 2A

Abstract: Hyperosmolarity can induce pro-inflammatory cytokine responses in colorectal and bladder epithelial cells. Inflammation appears to be the simple consequence of a shift of methylation of PP2A which in turn activates NF-kappaB.

Cited by 45 publications

References 56 publications

Carbon dioxide inhalation causes pulmonary inflammation

Carbon dioxide inhalation causes pulmonary inflammation

A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results

Sugar Alcohol Sweeteners as Alternatives to Sugar with Special Consideration of Xylitol

Contact Info

Product

Resources

About