Hyperostosing meningiomas of the sphenoid ridge—Clinical features, surgical therapy, and long-term observations: Review of 49 cases

Pompili, Alfredo; Derome, P; Visot, A; Guiot, G

doi:10.1016/s0090-3019(82)80006-2

Cited by 137 publications

(103 citation statements)

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“…According to this distribution based on the I/nI infiltrative index, it was possible to identify a total of 20 tumors with potential infiltrative/invasive behaviors (samples [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and 16 other tumors with the non-infiltrative phenotype (samples 22-37) (Table I). Only one tumor with a clinically described infiltrative phenotype (sample 21 in Table I), had an infiltrative index between 0.5 and 2 and therefore was unclassified tumor.…”

Section: Resultsmentioning

confidence: 99%

“…Driven by unknown cellular determinants, even though they are usually slow-growing tumors and even in their low-grade status, meningiomas often exhibit (in ~20% of the cases in our experience) a variety of general aggressive behaviors such as penetration of surrounding tissues, modification of bone structure, rapid regrowth of partially resected tumor and recurrence. Tissue infiltrations can target different anatomic areas or adjacent tissues such as the sinuses, the adjacent brain, or the skull bone, thereby causing major focally limited or extensive damage (1)(2)(3)(4)(5). Typically, the term invasion is restricted to infiltration into adjacent brain cortex.…”

Section: Introductionmentioning

confidence: 99%

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The heterogeneity of meningioma revealed by multiparameter analysis: infiltrative and non-infiltrative clinical phenotypes

Lages¹,

Ramus²,

Guttin³

et al. 2011

Int J Oncol

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Abstract.Tumor invasion or infiltration of adjacent tissues is the source of clinical challenges in diagnosis as well as prevention and treatment. Among brain tumors, infiltration of the adjacent tissues with diverse pleiotropic mechanisms is frequently encountered in benign meningiomas. We assessed whether a multiparametric analysis of meningiomas based on data from both clinical observations and molecular analyses could provide a consistent and accurate appraisal of invasive and infiltrative phenotypes and help determine the diagnosis of these tumors. Tissue analyses of 37 meningiomas combined enzyme-linked immunosorbent assay (ELISA) and surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) assays of two different protein biomarkers (thrombospondin 1 and a phosphorylated form of vimentin) as well as gene expression analyses with oligonucleotide microarrays. Up to four different clinical and molecular parameters were then examined for tumor classification. From this study, we were able to cluster 36 out of the 37 tumors into two different subsets corresponding to infiltrative/invasive and non-infiltrative tumors. In addition, meningiomas that invade brain and those that infiltrate the neighboring skull bone exhibited no distinguishable molecular features. Our multiparameter analysis that combines clinical data, transcriptomic and molecular assays clearly reveals the heterogeneity of meningiomas and distinguishes the intrinsically infiltrative/invasive tumors from the non-infiltrative meningiomas.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The heterogeneity of meningioma revealed by multiparameter analysis: infiltrative and non-infiltrative clinical phenotypes

Lages¹,

Ramus²,

Guttin³

et al. 2011

Int J Oncol

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show abstract

“…39 After gross total resection, almost all of the larger series with a minimum 5-year follow-up report a 5 to 10% recurrence rate. Subtotal resection, however, has at times been reported to increase the recurrence rate to as high as 60%, while in other cases it has appeared to facilitate growth arrest of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Association of Morbidity with Extent of Resection and Cavernous Sinus Invasion in Sphenoid Wing Meningiomas

et al. 2011

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).Cranial meningiomas occur on the sphenoid wing in 15 to 20% of all cases.1,2 The first surgical experience with sphenoid wing meningiomas (SWM) was reported by Cushing and Eisenhdardt 3 in 1938. They divided SWMs into four categories based on the following location: (1) tumors of the deep or clinoidal third, (2) middle-ridge tumors, (3) en-plaque pterional tumors, and (4) global pterional tumors. Although this system of nomenclature has to be slightly modified to account for contemporary multiplanar imaging and advances in microsurgical techniques, it remains for the most part accurate. Unfortunately, this classification system has not been widely used in the literature.Sphenoid wing meningiomas can involve the dura of the greater and lesser wings of the sphenoid, the anterior clinoid process, the spheno-orbital bone, and the middle cranial fossa. Moreover, the cavernous sinus, the orbital apex and superior and lateral orbital region, the sellar-suprasellar region, the pterygopalatine, temporal, and infratemporal fossae may also be infiltrated in more invasive cases.4 Consequently, the complex extension of these tumors, in addition to their proximity to vital neuronal and vascular structures, has always made them challenging for neurosurgeons. AbstractSphenoid wing meningiomas (SWMs) typically are histologically benign, insidious lesions, but the propensity of these tumors for local invasion makes disease control very challenging. In this review, we assess whether the degree of resection and extent of cavernous sinus invasion affects morbidity, mortality, and recurrence in patients with SWM. A comprehensive search of the English-language literature was performed. Patients were stratified according to extent of resection and extent of cavernous sinus invasion, and tumor recurrence rate, morbidity, and mortality were analyzed. A total of 23 studies and 131 patients were included. Overall recurrence and surgical mortality rate were 11% and 2%, respectively (average follow-up ¼ 65 months). Cranial nerve III palsy was significantly associated with incompletely versus completely resected SWMs (7 to 0%) as well as meningiomas with cavernous sinus invasion versus no sinus invasion (14 vs. 0%). No significant difference in tumor recurrence rate was noted between these groups. In conclusion, complete excision of SWMs is always recommended whenever possible, but surgeons should acknowledge that there is nonetheless a chance of recurrence and should weigh this against the risk of causing cranial nerve injuries.

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“…A ampla remoção óssea das fossas anterior e média foi preconizada por Pompili e cols. 43 em 1982. Na série de Mc Dermott e cols.…”

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Arq Bras Neurocir

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Hyperostosing meningiomas of the sphenoid ridge—Clinical features, surgical therapy, and long-term observations: Review of 49 cases

Cited by 137 publications

References 0 publications

The heterogeneity of meningioma revealed by multiparameter analysis: infiltrative and non-infiltrative clinical phenotypes

The heterogeneity of meningioma revealed by multiparameter analysis: infiltrative and non-infiltrative clinical phenotypes

Association of Morbidity with Extent of Resection and Cavernous Sinus Invasion in Sphenoid Wing Meningiomas

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