Hyperparathyroidism

Rossi, Ricardo L.; ReMine, Stephen G.; Clerkin, Eugene P.

doi:10.1016/s0039-6109(16)43624-8

Cited by 17 publications

(3 citation statements)

References 53 publications

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“…Clinical symptoms are varied and include lethargy, weakness, arthralgia and gastrointestinal symptoms. Neuromuscular and psychiatric symptoms are common [7]. Other symptoms include thirst and polyuria.…”

Section: Discussionmentioning

confidence: 99%

Unusual florid skeletal manifestations of primary hyperparathyroidism

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Unusual florid skeletal manifestations of primary hyperparathyroidism

et al. 2002

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“…In each case, the initial cervical exploration(s) had been unsuccessful because the pathological tissue lay deep within the mediastinum. Previous reports of failed cervical explorations emphasize that, in the majority of cases requiring reexploration, the "missing" gland is in the neck or accessible from the cervical incision [6,7,12]. Edis et al suggested that the reason for the unsuccessful initial exploration is "failure on the part of the surgeon to appreciate the nuances and variations of normal parathyroid anatomy" [13].…”

Section: Casementioning

confidence: 99%

The challenge of the middle mediastinal parathyroid

et al. 1988

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In most cases of persistent or recurrent hyperparathyroidism (HPT), the pathological parathyroid (PT) will be in the neck or accessible through the cervical approach, and in only a small percentage will median sternotomy be required. We present 3 cases of persistent HPT where the PT tissue was in the middle mediastinum. We acknowledge that this is a rare occurrence and that it cannot be explained adequately by standard embryological teaching. In cases requiring formal mediastinal exploration, the mediastinai exploration is not complete unless the middle mediastinum is carefully explored to exclude ectopic PT tissue.

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“…Primary hyperparathyroidism (PHP) is due to excessive parathormone secreted by one or more parathyroid glands and leads to varied manifestations due to hypercalcemia. Parathyroid adenoma is the most common cause of primary hyperparathyroidism and as much as 85% are single adenomas [1]. Surgery is the definitive therapy for PHP, which includes removal of affected parathyroid gland(s) [2].…”

Section: Introductionmentioning

confidence: 99%

Utility of Intraoperative Parathormone Assay as an Index to Successful Parathyroidectomy

Shenoy

Behl

Pawar

2014

Journal of Hormones

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Introduction. Surgery is the definitive treatment for primary hyperparathyroidism (PHP). Focused approaches for excision of single gland pathology are gaining popularity. Preoperative parathyroid localization and intraoperative parathormone (IOPTH) assay are essential components of successful parathyroidectomy using focused approach. Objective. To evaluate the efficacy of IOPTH in patients undergoing surgery for PHP. Methods. Retrospective review of twelve patients who underwent surgery for PHP at tertiary corporate hospital in Mumbai, India, between January 2009 and December 2012. Results. IOPTH had true results in 10 patients (83%) and led to unnecessary further exploration in 1 patient (8%). The concordance rate between ultrasonogram, sestamibi, and IOPTH was 66%. The mean decay of IOPTH was 65%, and all patients were normocalcemic at the end of six months. Conclusion. IOPTH is a useful adjunct to predict successful removal of the involved gland.

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Hyperparathyroidism

Cited by 17 publications

References 53 publications

Unusual florid skeletal manifestations of primary hyperparathyroidism

Unusual florid skeletal manifestations of primary hyperparathyroidism

The challenge of the middle mediastinal parathyroid

Utility of Intraoperative Parathormone Assay as an Index to Successful Parathyroidectomy

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