Hyperparathyroidism, A Forgotten Cause of Musculoskeletal Pain

Borgia, Ariel R.; Cavallasca, Javier A.; Costa, Cecilia A.; Musuruana, Jorge L.

doi:10.1016/j.reumae.2012.06.019

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…Vitamin D3 deficiency and HPT are established to be associated with Fibromyalgia syndrome 36 , 37 . Hyperparathyroidism is known to be associated with multiple articular manifestations including gout, pseudogout, juxtaarticular erosions, tenosynovitis, periarthritis, and pericapsular calcification 12 . Hyperparathyroidism is a cause of bone pain and aching joints due to osteoporosis or osteopenia because of the continued removal of calcium from bone as well as chondrocalcinosis and pseudogout.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Middle east pain syndrome is a pollution-induced new disease mimicking rheumatoid arthritis

Elbeialy

Bauomi

Elnaggar

et al. 2021

Sci Rep

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Musculoskeletal pains are sometimes misdiagnosed in some diseases, like rheumatoid and psoriatic arthritis, erosive OA, etc. Secondary hyperparathyroidism was not considered a differential diagnosis for RA, despite the fact that it can cause arthralgia or arthritis. Also, fibromyalgia is a psychosomatic condition marked by widespread pain and tenderness. This study included 400 patients attended certain outpatient clinics of Rheumatology in Egypt and Saudi Arabia, who were not fulfilling criteria for RA diagnosis. Criteria for classification of fibromyalgia syndrome were applied to all patients. We did lab tests and radiological imaging modalities for diagnosis or exclusion of suspected diseases were applied. All patients were fulfilling both old and new criteria of fibromyalgia syndrome, and not fulfilling any RA criteria, and had vitamin D3 deficiency or insufficiency. 75% of patients had abnormally high levels of PTH, without parathyroid gland pathology. Radiology showed subperiosteal and subchondral resorption of mainly thumbs, subchondral osteopenia of proximal and middle phalanges, mild subperiosteal resorption along the radial aspect of the middle phalanx and mild tuft erosions, besides changes in the carpus closely resembling those of rheumatoid arthritis, of ulnar styloid resorption, radiocarpal and scapho-trapezoid joint arthritis. Of special interest, the presence of tuft spur-like excrescences.

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Section: Discussionmentioning

confidence: 99%

“…Vitamin D3 deficiency and hyperparathyroidism have been linked to Fibromyalgia syndrome 11 , 12 . Meanwhile, gout, pseudogout, juxtaarticular erosions, tenosynovitis, periarthritis, and pericapsular calcification are just a few of the articular symptoms linked to hyperparathyroidism 13 .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Middle east pain syndrome is a pollution-induced new disease mimicking rheumatoid arthritis

Elbeialy

Bauomi

Elnaggar

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Hyperparathyroidism is known to be associated with multiple articular manifestations including gout, pseudogout, juxtaarticular erosions, tenosynovitis, periarthritis, and pericapsular calci cation [12].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D3 de ciency and hyperparathyroidism have been linked to Fibromyalgia syndrome [11,12]. Meanwhile, gout, pseudogout, juxtaarticular erosions, tenosynovitis, periarthritis, and pericapsular calci cation are just a few of the articular symptoms linked to hyperparathyroidism [13].…”

Section: Introductionmentioning

confidence: 99%

Middle East Pain Syndrome (MEPS) Vitamin D3 Deficiency Induced Hyperparathyroidism and Fibromyalgia Mimicking Rheumatoid Arthritis

et al. 2021

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Objectives: Musculoskeletal pains are sometimes misdiagnosed in some diseases, like rheumatoid and psoriatic arthritis, erosive OA, etc. Secondary hyperparathyroidism was not considered a differential diagnosis for RA, despite the fact that it can cause arthralgia or arthritis. Also, bromyalgia is a psychosomatic condition marked by widespread pain and tenderness.Methods: This study included 400 patients attended outpatient clinics of Al-Azhar Faculty of medicine in Egypt, and Elaj Specialized Clinics in Saudi Arabia, who were not ful lling criteria for RA diagnosis, and not responding to its treatment. Other diseases like psoriatic arthritis and erosive OA were excluded.Criteria for classi cation of bromyalgia syndrome were applied to all patients. We did lab tests of RF, ACPA, ESR, CRP, LFT, RFT, vitamin D3, PTH, calcium, phosphorus, and SUA. Radiological imaging modalities for diagnosis or exclusion of suspected diseases were applied.Results: All patients were ful lling both old and new criteria of bromyalgia syndrome, and not ful lling any RA criteria, 18% were seropositive with low RF titers and negative ACPA. All patients had vitamin D3 de ciency or insu ciency. 75% of patients had abnormally high levels of PTH, and had no parathyroid gland pathology. X-rays showed subperiosteal and subchondral resorption of mainly thumbs, subchondral osteopenia of proximal and middle phalanges, mild subperiosteal resorption along the radial aspect of the middle phalanx and mild tuft erosions, besides changes in the carpus closely resembling those of rheumatoid arthritis, of ulnar styloid resorption, radiocarpal and scapho-trapezoid joint arthritis.Of special interest, the presence of tuft spurs-like excrescences.

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“…The effect of age on serum biochemical markers showed that the variation between pre and postmenopausal groups were unclear insignificant but when compare with control group demonstrate significant differences this finding belongs PTH similar to recent study done by Guncha K and Gagan D that showed significant correlation of age with serum PTH in both pre-menopausal and postmenopausal women (29) because an impairment of ovarian function in postmenopausal women alter the metabolism of Ca and therefore reduce bone mass (30) . Borgia et al demonstrate the role of hyperparathyroidism in musculoskeletal pain of fibromyalgia (31) . In correspondence of present study with Cammozi et al and Safi et al observations that parathyroid hormone was significantly low in postmenopausal women (32,33) .…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Some Serum Biomarkers of Fibromyalgia Syndrome in Pre and Postmenopausal Women in Relation to Obesity

Saleh¹

2019

IJPS

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The objective of this study is to evaluate the level of parathyroid hormone, Co enzyme Q and total antioxidant status in serum’s women with fibromyalgia syndrome firstly, then to demonstrate if these biochemical markers affected by age and obesity. This study was performed at Rheumatology and Rehabilitation Consultation Unit in Baghdad Teaching Hospital. Venous blood sample were drawn from (59) female with FMS and (30) control (without FMS). The serum was obtained after on standing in order to coagulate then centrifuged. The mean age± SD of FMS group was (42.22±15.34) years and for control was (40.7±18.22) years. Those participants were subdivided into four different groups according to menopausal status and body mass index to estimate three biochemical markers in their serum. The assessment of serum both PTH and Co enzyme Q were done by enzyme linked immune sorbent assay (ELISA) while total antioxidant status (TAS) determination was done colorimetric ally. Statistical analysis was calculated by SPSS program version 24. Independent samples T-test for different group of patients Pearson correlation between serum’s biomarkers within different groups; P values < 0.05 means significant. The results record that serum’s PTH showed increasing significantly at same time of decreasing Co Q (P value<0.05) but TAS measuring register not significant decreased (P value> 0.05) in FMS comparing with control group. About the age; PTH serum level appear insignificant increased but Co Q & TAS were decreased (P value >0.05& P value< 0.05) respectively in post menopause comparing with pre menopause. For estimating serum’s biomarkers related with body mass index (BMI) as a sign of obesity. Serum PTH level record significant raise in obese group P value<0.003, insignificant variation in obese and non- obese groups (P value>0.05) in the same time TAS record a significant decrease in obese group P value= 0.00. In pre menopause (FMS and control): Serum TAS level correlate negatively and significantly with PTH (P value= 0.034). For age>55; PTH in both FMS& control show critical significant correlation P value=0.05. In pre and post menopause FMS show significant independent t-test belong to TAS (P value= 0.004). In obese group PTH correlate Co Q of 25<BMI>30 significantly P value=0.027 and P value=0.029. T test show significant in PTH and TAS between obese and non-obese. In conclusion the obesity and menopause play an imperative role in the etiology of FMS relative with serum’s biomarkers (PTH, Co Q and TAS).

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Hyperparathyroidism, A Forgotten Cause of Musculoskeletal Pain

Cited by 5 publications

References 7 publications

RETRACTED ARTICLE: Middle east pain syndrome is a pollution-induced new disease mimicking rheumatoid arthritis

RETRACTED ARTICLE: Middle east pain syndrome is a pollution-induced new disease mimicking rheumatoid arthritis

Middle East Pain Syndrome (MEPS) Vitamin D3 Deficiency Induced Hyperparathyroidism and Fibromyalgia Mimicking Rheumatoid Arthritis

The Assessment of Some Serum Biomarkers of Fibromyalgia Syndrome in Pre and Postmenopausal Women in Relation to Obesity

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