Hyperparathyroidism and New Onset Diabetes After Renal Transplantation

Ivarsson, Kjell; Clyne, Naomi; Almquist, Martin; Akaberi, Shahriar

doi:10.1016/j.transproceed.2013.07.076

Cited by 9 publications

(2 citation statements)

References 47 publications

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“…PTH increases blood levels of calcium by stimulating bones to release calcium, kidney to reclaim calcium from urine, and intestine to absorb calcium [8]. Most studies suggest that high level of PTH is associated with abnormal glucose metabolism and is related with the prevalence of DM [9]. Calcitonin has the opposite effect of PTH; it decreases osteoclastic activity and slows calcium release from bone [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of Duration and Complications of Type 2 Diabetes Mellitus on Diabetic Related Parameters, Adipocytokines and Calcium Regulating Hormones

Al-Attaby

Al-Lami

2019

eijs

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The present study aims to investigate the effects of duration and complications of type 2 diabetes mellitus on diabetic related parameters, adipocytokines and calcium regulating hormones. This study was conducted on eighty diabetic patients (41 male and 39 female) in Iraq, with an age range of 20-60 years and a disease duration range of 1-180 months. Blood samples were collected from the patients to determine three main types of biomarkers: diabetic-related parameters [Fasting blood sugar is FBS glycated hemoglobin (HbA1c), insulin, and insulin resistance (IR)], adipocytokines [adiponectin and tumor necrosis factor-Î± (TNF-Î±), and calcium regulating hormones [parathyroid hormone (PTH), calcitonin, and vitamin D]. The result showed increased levels of some parameters with the increase in duration of disease. Levels of FBS and HbA1c increased significantly (probability <0.05) in the second and the third categories of duration of disease (61-120 and 121-180 month) compared with the first category (1-60 month). Levels of insulin and IR were increased with the increase in duration of disease; this increase was found to be significant (p<0.05) when a comparison was made between the second and the third categories with the first category. Also, a similar trend was observed when a comparison was made between the third category and the second category. There was a significant (P<0.05) increase in the levels of TNF-Î± and calcitonin in the last category compared with the other categories, and a significant (P<0.05) increase in vitamin D levels in the last category compared with the first category. Non-significant (P>0.05) differences were found in the levels of adiponectin and PTH among all categories of duration of disease. When a comparison was made between the two groups of patients (with complications and without complications), a significant (P<0.05) increase was found in the levels of FBG, HbA1c, insulin, and IR in patients with complications as compared with patients without complications. A significant (P<0.05) decrease was found in calcitonin levels in patients with complications as compared with patients without complications. Non-significant (P>0.05) differences were found in the levels of the other parameters (adiponectin, TNF-Î±, PTH and vitamin D) between the two groups of patients. It can be concluded from the present study that duration of disease affects diabetic related parameters, TNF-Î± and some calcium regulating hormones (calcitonin and vitamin D), while complications of disease affect diabetic related parameters and calcitonin. It can be suggested that the duration of diabetes is one of the strongest determinants of complication risk.

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Section: Introductionmentioning

confidence: 99%

Effects of Duration and Complications of Type 2 Diabetes Mellitus on Diabetic Related Parameters, Adipocytokines and Calcium Regulating Hormones

Al-Attaby

Al-Lami

2019

eijs

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“…Hyperparathyroidism, both primary and secondary, can determine glucose intolerance and insufficient insulin release, thus leading to diabetes. Literature data show that increased levels of intact parathormone are associated with new-onset diabetes after transplantation (32,33).…”

Section: Discussionmentioning

confidence: 99%

A Severe Case of Hyperglycemia in a Kidney Transplant Recipient Undergoing Interferon-Free Therapy for Chronic Hepatitis C

et al. 2018

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Context. Hepatitis C and diabetes represent important health problems globally. The new-onset diabetes after transplantation is a particular entity that appears due to the use of immunosuppression among transplanted patients.Objective. We aim to describe the clinical and biological aspects of severe hyperglycemia in a kidney transplant recipient undergoing Interferon-free therapy for chronic hepatitis C, discussing the interference of different factors with the glucose metabolism.Design. The occurrence of diabetes in a patient with history of renal transplantation and Interferon-free treated hepatitis C was studied from both clinical and paraclinical points of view.Subjects and methods. When presenting to the hospital, extensive blood tests were performed on the patient, revealing significant hyperglycemia and an elevated level of blood tacrolimus. Creatinine clearance was calculated. ECG presented T-wave alterations. Intensive insulin protocol was applied, the case being managed in a multidisciplinary approach.Results. Blood glucose and tacrolimus were slowly normalized, under therapy. The antiviral treatment was continued, with the achievement of sustained virologic response.Conclusions. Diabetes mellitus can have many causes, hepatitis C and transplantation both having an impact on glucose metabolism. The association of the three entities should be carefully managed, due to its enhancing effect on morbidity and mortality.

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The incidence of new onset diabetes after transplantation and related factors: Single center experience

et al. 2017

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Hyperparathyroidism and New Onset Diabetes After Renal Transplantation

Cited by 9 publications

References 47 publications

Effects of Duration and Complications of Type 2 Diabetes Mellitus on Diabetic Related Parameters, Adipocytokines and Calcium Regulating Hormones

Effects of Duration and Complications of Type 2 Diabetes Mellitus on Diabetic Related Parameters, Adipocytokines and Calcium Regulating Hormones

A Severe Case of Hyperglycemia in a Kidney Transplant Recipient Undergoing Interferon-Free Therapy for Chronic Hepatitis C

The incidence of new onset diabetes after transplantation and related factors: Single center experience

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