Hyperparathyroidism as a cause of recurrent acute pancreatitis: A case report

Tešić-Rajković, Snežana; Radovanović-Dinić, Biljana; Mitić, Branka; Dinic-Radovic, Violeta; Jovanović, Maja

doi:10.2298/vsp150210121t

Cited by 1 publication

(1 citation statement)

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“…Approximately 7–19% of patients with hypercalcemia develop pancreatitis owing to obstruction of the pancreatic duct by stones, activation of trypsin by excess calcium in the secretions, increased alkalinity which precipitates calcium, and vasculitis within the pancreas. Hyperparathyroidism, either primary or secondary to vitamin D deficiency, has been described in association with hypercalcemia-mediated by AP [ 57 , 58 ].…”

Section: Vitamin D and Pancreatitis In Clinical Studiesmentioning

confidence: 99%

Vitamin D and Pancreatitis: A Narrative Review of Current Evidence

Cai

Chan-juan

et al. 2022

Nutrients

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Emerging research indicates that vitamin D metabolic disorder plays a major role in both acute pancreatitis (AP) and chronic pancreatitis (CP). This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). However, the role of vitamin D assessment and its management in pancreatitis remains poorly understood. In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Although further research is still required to establish the protective role of vitamin D and its application in disease, evaluation of vitamin D levels and its supplementation should be important strategies for pancreatitis management according to currently available evidence.

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Section: Vitamin D and Pancreatitis In Clinical Studiesmentioning

confidence: 99%