Hyperparathyroidism in peptic ulcer patients

Abstract

The high incidence of peptic ulcers and abdominal pain from other causes in patients with primary hyperparathyroidism has been recognized for many years. This paper reports 20 patients with hyperparathyroidism: 12 with peptic ulcers and 8 with abdominal pain from other causes. Only in a minority of these was the diagnosis of hypercalcaemia made as a result of a deliberately sought assay; in most the plasma calcium had been measured as part of a 'screening' procedure with a multichannel analyser. In almost all of the patients who had parathyroid surgery the abdominal symptoms were completely relieved. We urge that plasma calcium assays should be made in all patients with dyspepsia particularly those with recurrent symptoms.

Peptic Ulcer Perforation as the First Manifestation of Previously Unknown Primary Hyperparathyroidism

“…In various studies, the association of hypercalcemia and peptic ulcer is well established [1, 2, 3, 4], while in others this matter is still under debate [5, 6, 7, 8, 9, 10]. The fact is that 12% of patients with primary hyperparathyroidism have peptic ulcer-related symptoms [11, 12], and these symptoms can be relieved after surgical removal of the abnormal parathyroid gland(s) because of the reported reduction of elevated basal acid output (BAO) [1, 2, 3, 4].…”

“…The fact is that 12% of patients with primary hyperparathyroidism have peptic ulcer-related symptoms [11, 12], and these symptoms can be relieved after surgical removal of the abnormal parathyroid gland(s) because of the reported reduction of elevated basal acid output (BAO) [1, 2, 3, 4]. Here, we present a rare case of perforated duodenal ulcer as the initial clinical manifestation of unknown primary hyperparathyroidism.…”

Primary Hyperparathyroidism with Duodenal Ulcer and H. pylori Infection.

“…The association between hyperparathyroidism and the increased risk of peptic ulcer disease, on the other hand, is still controversial (6-ll). Several reports show that the elevated basal acid output (BAO)and dyspeptic symptomsof hyperparathyroidism can be reduced by surgical removal of affected parathyroids (12)(13)(14)(15), while in other reports, it has been considered as mere coincidence ( 16,17). Here, we present a case of primary hyperparathyroidism associated with duodenal ulcer, who showed a reversed result in gastric acid secretion before and after parathyroidectomy.…”

Peptic ulcer disease in children

“…Eighty per cent of adult patients had gastrointestinal symptoms such as abdominal pain and diarrhoea; dyspeptic symptoms often were associated with duodenal erosion or ulcers. 31 Other conditions associated with acid hypersecretion include short bowel syndrome 32,33 , hyperparathyroidism 34,35 and cystic ®brosis. Gastric acid hypersecretion is a transient phenomenon that can occur after massive short bowel resection (greater than two-thirds) in both infants and adults 32,33 , and can result in peptic ulceration.…”