Hyperphagia induced by GABAA receptor-mediated inhibition of the nucleus accumbens shell: Dependence on intact neural output from the central amygdaloid region.

Baldo, Brian A.; Alsene, Karen M; Negrón, Arnaldo E.; Kelley, Ann E.

doi:10.1037/0735-7044.119.5.1195

Cited by 39 publications

(34 citation statements)

References 79 publications

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“…Perhaps more germane to this discussion, shellmediated hyperphagia does not translate into enhanced operant responding for food (Zhang et al 2003). Moreover, hyperphagia-inducing shell manipulations during operant training enhance the acquisition of responding for food reward (Hanlon et al 2004;Baldo et al 2005). Thus, the feeding response elicited from the shell appears to resemble the release of fixed-action feeding patterns, in a manner reminiscent of stimulus-driven feeding elicited from the lateral hypothalamus Baldo and Kelley 2007).…”

Section: Mapping Behavior Onto the Circuits Of The Ventral Striatummentioning

confidence: 92%

The structural basis for mapping behavior onto the ventral striatum and its subdivisions

et al. 2008

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The striatum can be divided into dorsal (caudate-putamen) and ventral parts. In the ventral division, the nucleus accumbens, which subserves adaptive and goal-directed behaviors, is further subdivided into shell and core. Accumbal neurons show different types of experience-dependent plasticity: those in the core seem to discriminate the motivational value of conditioned stimuli, features that rely on the integration of information and enhanced synaptic plasticity at the many spines on these cells, whereas shell neurons seem to be involved with the release of predetermined behavior patterns in relation to unconditioned stimuli, and the behavioral consequences of repeated administration of addictive drugs. In the core, the principal neurons are medium sized and densely spiny, but in the medial shell, these same neurons are much smaller and their dendrites, significantly less spiny, suggesting that morphological differences could mediate unique neuroadaptations associated with each region. This review is focused on evaluating the structural differences in nucleus accumbens core and shell neurons and discusses how such different morphologies could underlie distinguishable behavioral processes.

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Section: Mapping Behavior Onto the Circuits Of The Ventral Striatummentioning

confidence: 92%

The structural basis for mapping behavior onto the ventral striatum and its subdivisions

et al. 2008

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“…This constitutes a PPI . We sought to identify "target" regions that showed differential connectivity according to the context (appetizing vs bland) with each of two source regions (the ventral striatum and the amygdala) consistently implicated in feeding and food reward by animal and human research (Rolls et al, 1980;Nishijo et al, 1988;Masuda et al, 1997;Baldo et al, 2005;Balleine and Killcross, 2006;O'Doherty et al, 2006); the amygdala and ventral striatum have also been implicated in other types of rewards such as money (Knutson and Bossaerts, 2007) and positive feedback (Cools et al, 2002). We also explored any connectivity pattern arising from the ventral ACC, given its wider role in emotion regulation (Davidson et al, 2000;Ochsner and Gross, 2005;Delgado et al, 2008) and extinction (Phelps et al, 2004;Delgado et al, 2008) (supplemental material, available at www.…”

Section: Methodsmentioning

confidence: 99%

“…Animal research has implicated a broad network mediating feeding behavior, including subcortical (ventral striatum, amygdala, hypothalamus), allocortical (hippocampus), and frontal cortical regions (motor, premotor, orbital and medial prefrontal cortices) (Masuda et al, 1997;Nishijo et al, 1997;Baldo et al, 2005;Kelley et al, 2005). Functional imaging research in humans has also highlighted the role of these regions in food processing (Small, 2002;Killgore et al, 2003;DelParigi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Passamonti¹,

Rowe²,

Schwarzbauer³

et al. 2009

J. Neurosci.

123

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Eating is not only triggered by hunger but also by the sight of foods. Viewing appetizing foods alone can induce food craving and eating, although there is considerable variation in this "external food sensitivity" (EFS). Because increased EFS is associated with overeating, identifying its neural correlates is important for understanding the current epidemic of obesity. Animal research has identified the ventral striatum, amygdala, hypothalamus, medial prefrontal and premotor cortices as key interacting structures for feeding. However, it is unclear whether a similar network exists in humans and how it is affected by EFS. Using functional magnetic resonance imaging, we showed that viewing appetizing compared with bland foods produced changes in connectivity among the human ventral striatum, amygdala, anterior cingulate and premotor cortex that were strongly correlated with EFS. Differences in the dynamic interactions within the human appetitive network in response to pictures of appetizing foods may determine an individual's risk of obesity.

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“…In contrast, microinjection of GABA A receptor antagonist significantly blocked this inhibitory effect. Moreover, Baldo et al (20) observed that GABA A agonist infusion into the central amygdala reduced feeding elicited either by stimulation of the nucleus accumbens shell or by food deprivation. Similarly, infusion of TTX into the central amygdala blocked hyperphagia induced by the nucleus accumbens shell stimulation.…”

Section: Central Amygdalamentioning

confidence: 99%

Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse

Knapska¹,

Radwańska²,

Werka³

et al. 2007

Physiological Reviews

140

134

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The amygdala is a heterogeneous brain structure implicated in processing of emotions and storing the emotional aspects of memories. Gene activity markers such as c-Fos have been shown to reflect both neuronal activation and neuronal plasticity. Herein, we analyze the expression patterns of gene activity markers in the amygdala in response to either behavioral training or treatment with drugs of abuse and then we confront the results with data on other approaches to internal complexity of the amygdala. c-Fos has been the most often studied in the amygdala, showing specific expression patterns in response to various treatments, most probably reflecting functional specializations among amygdala subdivisions. In the basolateral amygdala, c-Fos expression appears to be consistent with the proposed role of this nucleus in a plasticity of the current stimulus-value associations. Within the medial part of the central amygdala, c-Fos correlates with acquisition of alimentary/gustatory behaviors. On the other hand, in the lateral subdivision of the central amygdala, c-Fos expression relates to attention and vigilance. In the medial amygdala, c-Fos appears to be evoked by emotional novelty of the experimental situation. The data on the other major subdivisions of the amygdala are scarce. In conclusion, the studies on the gene activity markers, confronted with other approaches involving neuroanatomy, physiology, and the lesion method, have revealed novel aspects of the amygdala, especially pointing to functional heterogeneity of this brain region that does not fit very well into contemporarily active debate on serial versus parallel information processing within the amygdala.

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Hyperphagia induced by GABAA receptor-mediated inhibition of the nucleus accumbens shell: Dependence on intact neural output from the central amygdaloid region.

Cited by 39 publications

References 79 publications

The structural basis for mapping behavior onto the ventral striatum and its subdivisions

The structural basis for mapping behavior onto the ventral striatum and its subdivisions

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse

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