2013
DOI: 10.1185/03007995.2013.841667
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Hyperphosphatemia and phosphate binders: effectiveness and safety

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Cited by 9 publications
(7 citation statements)
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“…Lanthanum ( Z =57) in the form of La 2 CO 3 (Fosrenol) was approved in 2004 for treatment of hyperphosphatemia [ 256 ], an electrolyte imbalance that results in elevated levels of phosphate in the blood. Hyperphosphatemia is more severe in patients suffering from renal failure as a result of increased FGF-23 levels, secondary hyperparathyroidism and enhanced progressive vascular calcification [ 257 ]. Fosrenol acts as a phosphate binder, reducing absorption of phosphate through the formation of insoluble lanthanum phosphate complexes which can then pass through the grastrointestinal tract unabsorbed [ 258 ].…”
Section: Groups 3–12: the Transitions Metalsmentioning
confidence: 99%
“…Lanthanum ( Z =57) in the form of La 2 CO 3 (Fosrenol) was approved in 2004 for treatment of hyperphosphatemia [ 256 ], an electrolyte imbalance that results in elevated levels of phosphate in the blood. Hyperphosphatemia is more severe in patients suffering from renal failure as a result of increased FGF-23 levels, secondary hyperparathyroidism and enhanced progressive vascular calcification [ 257 ]. Fosrenol acts as a phosphate binder, reducing absorption of phosphate through the formation of insoluble lanthanum phosphate complexes which can then pass through the grastrointestinal tract unabsorbed [ 258 ].…”
Section: Groups 3–12: the Transitions Metalsmentioning
confidence: 99%
“…Phosphatebinders have different effects on FGF-23 levels. Recent studies showed that lanthanum carbonate and sevelamer were effective in reducing FGF23 levels; this effect was not observed with calcium carbonate (14,15) (19).…”
Section: Resultsmentioning
confidence: 99%
“…In humans there is evidence that hyperphosphatemia is associated with vascular calcification and nephrocalcinosis, with a subsequent more rapid disease progression [19]. The situation in cats appears to be different.…”
Section: Discussionmentioning
confidence: 99%