Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma

Moreira, Camila Guimarães; Horinouchi, Cíntia Delai da Silva; Souza-Filho, Claudio S.; Campos, Francinete Ramos; Barison, Andersson; Cabrini, Daniela Almeida; Otuki, Michel Fleith

doi:10.1016/j.jep.2012.03.047

Cited by 29 publications

(21 citation statements)

References 37 publications

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“…It has been shown that human placental lipid (25), sesamin (26), quercetin (27), and extracts from Erica multiflora (28) and Pyrostegia venusta (29) can increase melanogenesis in vitro. Thus, these compounds and extracts can be considered as candidates for developing tanning cosmetics and medicines for vitiligo.…”

Section: Discussionmentioning

confidence: 99%

Melia azedarach extract stimulates melanogenesis through increase of tyrosinase-related protein 1 expression in B16F10 mouse melanoma cells

Cheng

Jin

et al. 2015

International Journal of Molecular Medicine

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Abstract. Melia azedarach (MA) has been used in folk medicine in Asia for the treatment of several diseases. Several constituents from MA possess anti-herpetic, anti-angiogenic and anticancer properties. The aim of the present study was to investigate the effect of a 70% ethanol extract of MA on melanogenesis and the underlying mechanisms involved. A B16F10 mouse melanoma cell line was used in our experiments. Treatment of B16F10 cells with the MA extract (10, 20 and 40 µg/ml) increased melanin content in a concentration-dependent manner without cytotoxicity at 24 h. Further experiments indicated that the MA extract (20 µg/ml) increased melanin content as early as at 4 h after treatment. Additionally, although the MA extract did not affect intracellular tyrosinase activity and the protein levels of tyrosinase and tyrosinase-related protein-2 (TRP-2) at 2 and 4 h after treatment, the MA extract increased TRP-1 protein expression at both time points. However, no significant effect of the MA extract treatment on TRP-1 mRNA level at the time points measured was observed. In conclusion, the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells and suggest that the MA extract can be viewed as a rapid inducer of melanogenesis, thus rendering it a potential treatment for hypopigmentation diseases including vitiligo.

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Section: Discussionmentioning

confidence: 99%

Melia azedarach extract stimulates melanogenesis through increase of tyrosinase-related protein 1 expression in B16F10 mouse melanoma cells

Cheng

Jin

et al. 2015

International Journal of Molecular Medicine

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“…Miers, family Bignoniaceae, is traditionally used to treat erysipelas as well as pulmonary and vaginal infections [9,10]. Compounds isolated from the extracts of this species present antioxidant and antimicrobial activities and elicit hyperpigmentation [11,12]. Veloso et al [13] have reported that this species is useful to treat flu and cold symptoms induced by lipopolysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta (Ker Gawl.) Miers

Pereira

Hernandes

Pereira

et al. 2014

Chemico-Biological Interactions

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“…The findings were significant in designing preclinical and clinical studies on the efficacy of C. occidentalis as a stimulant for skin regimentation in vitiligo [10]. Moreira et al [11] investigated the melanogenic activity of hydro alcoholic extracts from the leaves and flowers of P. venusta on murine B16F10 melanoma cells. Both extracts, leaves increased the melanin content in a dose dependent manner on melanoma cells.…”

Section: Effect Of Herbal Extract and Their Actives On Melanogenesismentioning

confidence: 99%

Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease

Zaidi¹

2017

IJMBOA

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The synthesis of melanin pigments or melanogenesis has many important physiological functions that include photo protection of the human skin from ultraviolet (UV) irradiation. Melanogenesis is a complex pathway involving melanin synthesis, melanin transport, and melanosome release. Melanin synthesis is stimulated by various effects such as α-melanocyte-stimulating hormone (α-MSH); cyclic AMP (cAMP) elevating agents including palmitic acid, methyl ester, psoralen, thymoquinone, piperine, berberine and withaferin-A. Loss of the hair shaft melanin is associated with decrease of tyrosinase activity in the bulb of melanocytes. Activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. This is only report authors found in literature about tyrosinase activation. Melanogenesis stimulator are rarely studied as most industries are more interested on inhibitors of the enzyme in order to reduce the adverse effects of melanin formation in, for example, processed food and human skin. Hence, there is a need to review the successful utilization of tyrosinase stimulators from natural herbs for medicinal applications.

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Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma

Abstract: The leaves and flowers extracts of P. venusta stimulates B16F10 melanogenesis at very low concentrations. These findings support the folk medicinal use of P. venusta on the treatment of hypopigmentation diseases, such as vitiligo.

Cited by 29 publications

References 37 publications

Melia azedarach extract stimulates melanogenesis through increase of tyrosinase-related protein 1 expression in B16F10 mouse melanoma cells

Melia azedarach extract stimulates melanogenesis through increase of tyrosinase-related protein 1 expression in B16F10 mouse melanoma cells

Evaluation of anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta (Ker Gawl.) Miers

Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease

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