Hyperplastic (metaplastic) polyps of the colon

Frazin, G; Zamboni, Giuseppe; Scarpa, Aldo; Dina, Roberto; Iannucci, Antonio; Novelli, Paula Cristina Steffen

doi:10.1097/00000478-198409000-00008

Cited by 57 publications

(16 citation statements)

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“…Unlike adenomas, sporadic hyperplastic polyps are considered to have no significant malignant potential. 33,34 However, the histogenesis of hyperplastic polyps is unclear. They are thought to arise as a result of aberrant differentiation of epithelial cells of the crypt with hypermaturation of surface epithelium 35 resulting from decreased apoptosis in the upper part of the crypts.…”

Section: Discussionmentioning

confidence: 99%

The Loss of Sarco/Endoplasmic Reticulum Calcium Transport ATPase 3 Expression Is an Early Event during the Multistep Process of Colon Carcinogenesis

Brouland¹,

Gélébart²,

Kovàcs³

et al. 2005

The American Journal of Pathology

116

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Calcium accumulation in the endoplasmic reticulum is accomplished by sarco/endoplasmic reticulum calcium transport ATPases (SERCA enzymes). To better characterize the role of SERCA3 in colon carcinogenesis, its expression has been investigated in colonic epithelium, benign lesions, adenomas, and adenocarcinomas. In addition, the regulation of SERCA3 expression was analyzed in the context of the adenomatous polyposis coli/␤-catenin/T-cell factor 4 (TCF4) pathway and of specificity protein 1 (Sp1)-like factordependent transcription. We report that SERCA3 expression increased along the crypts as cells differentiated in normal colonic mucosa and in hyperplastic polyps, was moderately and heterogeneously expressed in colonic adenomas with expression levels inversely correlated with the degree of dysplasia, was barely detectable in well and moderately differentiated adenocarcinomas, and was absent in poorly differentiated tumors. Inhibition of Sp1-like factor-dependent transcription blocked SERCA3 expression during cell differentiation, and Calcium homeostasis of the endoplasmic reticulum (ER) is involved in several essential cell functions. Calcium stored in the ER is required for chaperone-assisted maturation of newly synthesized proteins transiting through the organelle. 1-3 Moreover, second messenger-induced calcium release from the ER through inositol-tris-phosphate-and ryanodine receptor-type calcium channels constitutes an integral part of many intracellular signal transduction pathways and networks. 4,5 Because ER calcium homeostasis is therefore involved in many constitutive or inducible cell functions, calcium accumulation into this organelle, assured by sarco/endoplasmic reticulum calcium transport ATPase (SERCA)-type calcium pumps is essential for numerous cellular activities such as secretion, neuronal plasticity, stress responses, proliferation, differentiation, or various forms of cell death. 6 -12 Three SERCA genes are known that code by alternative splicing several isoforms, the expression of which is tissue dependent and developmentally regulated. 13

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Section: Discussionmentioning

confidence: 99%

The Loss of Sarco/Endoplasmic Reticulum Calcium Transport ATPase 3 Expression Is an Early Event during the Multistep Process of Colon Carcinogenesis

Brouland¹,

Gélébart²,

Kovàcs³

et al. 2005

The American Journal of Pathology

116

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“…14,17,35 The conceptual and morphologic road that led to the concept that some nonadenomatous hyperplastic-like polyps are preneoplastic precursor lesions is convoluted. Numerous small studies described or photographed hyperplastic-like lesions as an unusual change in hyperplastic polyps, 11,81-85 as part of mixed hyperplastic-adenomatous polyps, 18,81,82,[85][86][87][88][89][90][91] or as lesions adjacent to adenocarcinomas. [92][93][94][95][96] The term serrated was first applied by Longacre and Fenoglio-Preiser 17 to architecturally serrated, mixed, adenomatous, and hyperplastic-like polyps.…”

Section: Discussionmentioning

confidence: 99%

Hyperplastic-like Colon Polyps That Preceded Microsatellite-Unstable Adenocarcinomas

Goldstein

Bhanot

Odish

et al. 2003

American Journal of Clinical Pathology

116

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We compared hyperplastic-like polyps that preceded microsatellite-unstable adenocarcinomas to incidental hyperplastic polyps to identify distinguishing morphologic criteria. The study group included 106 hyperplastic-like, nonadenomatous, serrated polyps, most from the ascending colon in 91 patients; the control group included 106 rectosigmoid hyperplastic polyps from 106 patients in whom adenocarcinoma did not develop. Study group polyps had an expanded crypt proliferative zone, a serrated architectural outline that became apparent in the basilar crypt regions, basilar crypt dilation, inverted crypts, and a predominance of dysmaturational crypts (crypts with minimal cell maturation). In contrast, control group polyps had a proliferative zone confined to the basal crypt region, serrated architecture that became apparent in the superficial crypt region, rare to no basilar crypt dilation, and rare or no dysmaturational crypts. Hyperplastic-like polyps that preceded microsatellite-unstable adenocarcinomas had a distinctive constellation of morphologic features related to altered and decreased cell function and control that resulted in dysmaturational crypts. Dysmaturation constitutes a range of morphologic alterations, some of which overlap with incidental-type innocuous hyperplastic polyps. The morphologic features described herein provide initial guidelines to identify this potentially important subset of premalignant serrated-like polyps.

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“…Premalignant, as well as malignant lesions in the colon can be graded according to histological differentiation, and the low grade to high grade adenoma to in situ and invasive well/moderately/poorly differentiated adenocarcinoma sequence corresponds to the sequential loss of phenotypic differentiation and increased malignant potential. Small lesions called hyperplastic polyps of Morson, which, in contrast to adenomas, are devoid of significant potential to develop into carcinoma can also arise in the colon [82,83,84]. …”

Section: The Serca Multigene Family Co-expression Of Serca2 and Smentioning

confidence: 99%

Endoplasmic Reticulum Calcium Pumps and Cancer Cell Differentiation

et al. 2012

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The endoplasmic reticulum (ER) is a major intracellular calcium storage pool and a multifunctional organelle that accomplishes several calcium-dependent functions involved in many homeostatic and signaling mechanisms. Calcium is accumulated in the ER by Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA)-type calcium pumps. SERCA activity can determine ER calcium content available for intra-ER functions and for calcium release into the cytosol, and can shape the spatiotemporal characteristics of calcium signals. SERCA function therefore constitutes an important nodal point in the regulation of cellular calcium homeostasis and signaling, and can exert important effects on cell growth, differentiation and survival. In several cell types such as cells of hematopoietic origin, mammary, gastric and colonic epithelium, SERCA2 and SERCA3-type calcium pumps are simultaneously expressed, and SERCA3 expression levels undergo significant changes during cell differentiation, activation or immortalization. In addition, SERCA3 expression is decreased or lost in several tumor types when compared to the corresponding normal tissue. These observations indicate that ER calcium homeostasis is remodeled during cell differentiation, and may present defects due to decreased SERCA3 expression in tumors. Modulation of the state of differentiation of the ER reflected by SERCA3 expression constitutes an interesting new aspect of cell differentiation and tumor biology.

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Hyperplastic (metaplastic) polyps of the colon

Cited by 57 publications

References 0 publications

The Loss of Sarco/Endoplasmic Reticulum Calcium Transport ATPase 3 Expression Is an Early Event during the Multistep Process of Colon Carcinogenesis

The Loss of Sarco/Endoplasmic Reticulum Calcium Transport ATPase 3 Expression Is an Early Event during the Multistep Process of Colon Carcinogenesis

Hyperplastic-like Colon Polyps That Preceded Microsatellite-Unstable Adenocarcinomas

Endoplasmic Reticulum Calcium Pumps and Cancer Cell Differentiation

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