Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality

Pedersen, Michael; Ursprung, Stephan; Jensen, Jens Dam; Jespersen, Bente; Gallagher, Ferdia A.; Laustsen, Christoffer

doi:10.1007/s10334-019-00801-y

Cited by 11 publications

(10 citation statements)

References 79 publications

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“…All MRI methods can be applied in humans [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. However, the use of gadolinium contrast agents is contradicted in severe CKD, and as such, alternative methods would likely be used to determine the hemodynamic nature of kidneys in humans [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging

et al. 2020

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Fibrosis is often heterogeneously distributed, and classical biopsies do not reflect this. Noninvasive methods for renal fibrosis have been developed to follow chronic kidney diseases (CKD) and to monitor anti-fibrotic therapy. In this study, we combined two approaches to assess fibrosis regression following renal ischemia-reperfusion injury (IRI): magnetic resonance imaging (MRI) and noninvasive extracellular matrix (ECM) biomarkers. MRI was used to evaluate fibrosis in bilateral IRI in rats after reperfusion at 7, 14, and 21 days. This was performed with 1HT1 and T2* mapping, dynamic contrast-enhanced (DCE)-MRI, and chemical shift imaging (CSI)-23Na. The degradation of laminin gamma-1 chain (LG1M) and type III collagen (C3M) was measured in urine and plasma. Fibrosis was analyzed in tissue using fibronectin (FN) and alpha-smooth muscle actin (α-SMA) using quantitative polymerase chain reaction qPCR and western blotting. We found increased fibrosis 7 days after reperfusion, which dropped to sham levels after 21 days. Single kidney glomerular filtration rate (skGFR), perfusion (DCE-MRI), and total 23Na kidney content correlated positively with fibrotic markers FN and α-SMA as well as noninvasive LG1M and C3M. We showed that novel MRI protocols and ECM markers could track fibrogenic development. This could give rise to a multi-parametric practice to diagnose and assess fibrosis whilst treating kidney disease without using invasive methods.

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Section: Discussionmentioning

confidence: 99%

Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging

et al. 2020

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“…From the pre-clinical indications, it is very likely that metabolic and functional imaging with HP 13 C MRI will be a future diagnostic tool in kidney disease. The results are promising in the application of [1- 13 C]pyruvate and have shown potential with other carbon-based probes [1,4- 13 C]fumarate, 13 C-urea [ 66 ] and [1- 13 C]lactate [ 67 ]. Alternative biomarkers with improved relaxation properties also hold great promise in perfusion assessment [ 68 ].…”

Section: Applications Of Hyperpolarized Carbon-13 Mrimentioning

confidence: 99%

Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

2021

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This review provides a comprehensive assessment of the development of hyperpolarized (HP) carbon-13 metabolic MRI from the early days to the present with a focus on clinical applications. The status and upcoming challenges of translating HP carbon-13 into clinical application are reviewed, along with the complexity, technical advancements, and future directions. The road to clinical application is discussed regarding clinical needs and technological advancements, highlighting the most recent successes of metabolic imaging with hyperpolarized carbon-13 MRI. Given the current state of hyperpolarized carbon-13 MRI, the conclusion of this review is that the workflow for hyperpolarized carbon-13 MRI is the limiting factor.

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“…Hyperpolarization techniques have great potential for explorations into renal metabolic diseases (e.g., hyperpolarized 13 C-MRI), where SNR is boosted up to a 20,000-fold compared to conventional 13 C-MRI [58]. Experimental protocols to perform hyperpolarized 13…”

Section: Multinuclear Imagingmentioning

confidence: 99%

Hardware Considerations for Preclinical Magnetic Resonance of the Kidney

Delgado

Küstermann

Kühne³

et al. 2021

Methods in Molecular Biology

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Magnetic resonance imaging (MRI) is a noninvasive imaging technology that offers unparalleled anatomical and functional detail, along with diagnostic sensitivity. MRI is suitable for longitudinal studies due to the lack of exposure to ionizing radiation. Before undertaking preclinical MRI investigations of the kidney, the appropriate MRI hardware should be carefully chosen to balance the competing demands of image quality, spatial resolution, and imaging speed, tailored to the specific scientific objectives of the investigation. Here we describe the equipment needed to perform renal MRI in rodents, with the aim to guide the appropriate hardware selection to meet the needs of renal MRI applications.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This chapter on hardware considerations for renal MRI in small animals is complemented by two separate publications describing the experimental procedure and data analysis.

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Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality

Cited by 11 publications

References 79 publications

Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging

Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging

Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

Hardware Considerations for Preclinical Magnetic Resonance of the Kidney

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