Hyperpolarised 13C-MRI using 13C-pyruvate in breast cancer: A review

Arponen, Otso; Wodtke, Pascal; Gallagher, Ferdia A; Woitek, Ramona

doi:10.1016/j.ejrad.2023.111058

Cited by 4 publications

(3 citation statements)

References 82 publications

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“…Since then, the metabolism of hyperpolarized 13 C-pyruvate to hyperpolarized 13 C-lactate has been demonstrated in several tumors, including those of the prostate, pancreas, kidney, breast, and brain. Hyperpolarized 13 C MRI in oncology is virtually able to stratify tumors by grade, select therapeutic pathways based on tumor metabolic profiles, and detect early treatment response through the imaging of the metabolism shifts that precede tumor structural changes [11,102]. In gliomas, as an example, it has been demonstrated that hyperpolarized 13 C-pyruvate can detect metabolic subtypes, which can be dichotomized into more glycolytic and oxidative subtypes that have differing drug and radiation sensitivities [103,104].…”

Section: C-malate Necrosismentioning

confidence: 99%

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review

Frijia,

Flori,

Giovannetti

et al. 2024

Diagnostics

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Cardiovascular disease shows, or may even be caused by, changes in metabolism. Hyperpolarized magnetic resonance spectroscopy and imaging is a technique that could assess the role of different aspects of metabolism in heart disease, allowing real-time metabolic flux assessment in vivo. In this review, we introduce the main hyperpolarization techniques. Then, we summarize the use of dedicated radiofrequency 13C coils, and report a state of the art of 13C data acquisition. Finally, this review provides an overview of the pre-clinical and clinical studies on cardiac metabolism in the healthy and diseased heart. We furthermore show what advances have been made to translate this technique into the clinic in the near future and what technical challenges still remain, such as exploring other metabolic substrates.

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Section: C-malate Necrosismentioning

confidence: 99%

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review

Frijia,

Flori,

Giovannetti

et al. 2024

Diagnostics

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“…Thus, the prevalence of a high rate of glucose catabolism into lactate is the most widespread metabolic phenotype observed in cancer cells [ 3 ]. The presence of the Warburg effect has been described in most tumor types, including, but not limited to, glioblastoma [ 4 ], pancreas [ 5 ], breast [ 6 , 7 ], and cervix [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting the Warburg Effect in Cancer: Where Do We Stand?

Barba,

Carrillo-Bosch,

Seoane

2024

IJMS

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The Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for cancer therapy. Elevated lactate levels and acidic pH within the tumor microenvironment (TME) resulting from glycolytic profoundly impact various cellular populations, including macrophage reprogramming and impairment of T-cell functionality. Altogether, the Warburg effect has been shown to promote tumor progression and immunosuppression through multiple mechanisms. This review provides an overview of the current understanding of the Warburg effect in cancer and its implications. We summarize recent pharmacological strategies aimed at targeting glycolytic enzymes, highlighting the challenges encountered in achieving therapeutic efficacy. Additionally, we examine the utility of the Warburg effect as an early diagnostic tool. Finally, we discuss the multifaceted roles of lactate within the TME, emphasizing its potential as a therapeutic target to disrupt metabolic interactions between tumor and immune cells, thereby enhancing anti-tumor immunity.

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“…Impaired function of mitochondrial pyruvate carriers may induce tumors with strong proliferation, migration and invasion capabilities [ 11 ]. Coincidentally, several researches have also found that pyruvate metabolism affects the proliferation, differentiation and metastasis of BC cell lines [ 12 – 14 ]. Reports on the link between pyruvate metabolism and BC risk, however, are not readily available.…”

Section: Introductionmentioning

confidence: 99%

Integrating molecular pathway with genome-wide association data for causality identification in breast cancer

Li,

Jiang

2024

Discov Onc

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Objective The study purpose was to explore the causal association between pyruvate metabolism and breast cancer (BC), as well as the molecular role of key metabolic genes, by using bioinformatics and Mendelian randomization (MR) analysis. Methods We retrieved and examined diverse datasets from the GEO database to ascertain differentially acting genes (DAGs) in BC via differential expression analysis. Following this, we performed functional and pathway enrichment analyses to ascertain noteworthy molecular functions and metabolic pathways in BC. Employing MR analysis, we established a causal association between pyruvate metabolism and the susceptibility to BC. Additionally, utilizing the DGIdb database, we identified potential targeted medications that act on genes implicated in the pyruvate metabolic pathway and formulated a competing endogenous RNA (ceRNA) regulatory network in BC. Results We collected the datasets GSE54002, GSE70947, and GSE22820, and identified a total of 1127 DEGs between the BC and NC groups. GO and KEGG enrichment analysis showed that the molecular functions of these DEGs mainly included mitotic nuclear division, extracellular matrix, signaling receptor activator activity, etc. Metabolic pathways were mainly concentrated in PI3K−Akt signaling pathway, Cytokine−cytokine receptor binding and Pyruvate, Tyrosine, Propanoate and Phenylalanine metabolism, etc. In addition, MR analysis demonstrated a causal relationship between pyruvate metabolism and BC risk. Finally, we constructed a regulatory network between pathway genes (ADH1B, ACSS2, ACACB, ADH1A, ALDH2, and ADH1C) and targeted drugs, as well as a ceRNA (lncRNA-miRNA-mRNA) regulatory network for BC, further revealing their interactions. Conclusions Our research revealed a causal association between pyruvate metabolism and BC risk, found that ADH1B, ACSS2, ACACB, ADH1A, ALDH2, and ADH1C takes place an important part in the development of BC in the molecular mechanisms related to pyruvate metabolism, and identified some potential targeted small molecule drugs.

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Hyperpolarised 13C-MRI using 13C-pyruvate in breast cancer: A review

Cited by 4 publications

References 82 publications

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review

Targeting the Warburg Effect in Cancer: Where Do We Stand?

Integrating molecular pathway with genome-wide association data for causality identification in breast cancer

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