Hyperpolarization Methods for MRS

Goodson, Boyd M.; Whiting, Nicholas; Coffey, Aaron M.; Nikolaou, Panayiotis; Shi, Fan; Gust, Brogan M.; Gemeinhardt, Maxwell E; Shchepin, Roman V.; Skinner, Jason G.; Birchall, Jonathan R; Barlow, Michael J.; Chekmenev, Eduard Y.

doi:10.1002/9780470034590.emrstm1457

Cited by 50 publications

(114 citation statements)

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“…[1] Thus, hyperpolarization holds promise to revolutionize clinical MR imaging and spectroscopy. Hyperpolarization techniques that derive their spin order from para hydrogen (pH 2 ) combine a number of attractive advantages, including very low costs, low instrumentation demands, and rapid, high-throughput, and scalable production of hyperpolarized (HP) agents in the liquid state.…”

Section: Introductionmentioning

confidence: 99%

Parahydrogen‐Based Hyperpolarization for Biomedicine

et al. 2018

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Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH ), which is inherently stable and long-lived. When brought into contact with another molecule, this "spin order on demand" allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH -based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.

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Section: Introductionmentioning

confidence: 99%

Parahydrogen‐Based Hyperpolarization for Biomedicine

et al. 2018

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“…[1][2][3] This significant increase in P enables metabolic magnetic resonance spectroscopy (MRS) and MRS imaging( MRSI) after ab olus injectiono fahyperpolarized (HP) compound to detecta bnormal metabolism in cancera nd other diseases. [1][2][3] This significant increase in P enables metabolic magnetic resonance spectroscopy (MRS) and MRS imaging( MRSI) after ab olus injectiono fahyperpolarized (HP) compound to detecta bnormal metabolism in cancera nd other diseases.…”

Section: Introductionmentioning

confidence: 99%

Hyperpolarizing Concentrated Metronidazole ¹⁵NO₂ Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime

Shchepin

Birchall

Чуканов

et al. 2019

Chemistry A European J

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118

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The NMR hyperpolarization of uniformly 15 N-labeled [ 15 N 3 ]metronidazole is demonstrated by using SABRE-SHEATH. In this antibiotic, the 15 NO 2 group is hyperpolarized throughs pin relays createdb y 15 Ns pins in [ 15 N 3 ]metronidazole, and the polarization is transferred from parahydrogen-derivedh ydrides over six chemical bonds. In less than am inute of parahydrogen bubbling at approximately 0.4 mT, ah igh level of nuclear spin polarization( P 15N ) of around 16 %i sa chieved on all three 15 Ns ites. This prod-uct of 15 Np olarization andc oncentration of 15 Ns pins is arounds ix-fold bettert han any previous value determined for 15 NS ABRE-derived hyperpolarization. At 1.4 T, the hyperpolarized state persists fort ens of minutes (relaxation time, T 1 %10 min). An ovel synthesis of uniformly 15 N-enriched metronidazole is reported with ay ield of 15 %. This approachc an potentially be used for synthesis of aw ide variety of in vivom etabolic probesw ith potentialu ses ranging from hypoxiasensing to theranostic imaging.[a] Prof.

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“…In addition to the NMR study of HP Xe in the gas phase and the studies of tissue-dissolved Xe as described above, the affinity of xenon to reside in hydrophobic pockets enables additional insights, This phenomenon made xenon a tool for exploring binding sites on protein surfaces [2c] with some effort being put on spin polarization transfer to nuclei in nearby residues that form the catalytic site of enzymes. Hence, detection of proton signals with and without adding HP nuclei could identify the pocket-related residues.…”

Section: 129xe Cages and Hyper-cest Mrimentioning

confidence: 99%

“…[2b, 4] (a) SEOP cell containing a noble gas (here, Xe), buffer gases (e.g. N 2 ), and a small quantity of vaporized alkali metal (here, Rb); the cell is irradiated by circularly polarized laser light that can be absorbed by the alkali metal atoms.…”

Section: Figurementioning

confidence: 99%

“…[1] This process of significant polarization enhancement—well above that achieved at thermal equilibrium—is termed hyperpolarization . Hyperpolarization of solids, liquids, and gases [2] has been demonstrated via a number of techniques including Brute Force Polarization (BFP), [3] Spin Exchange Optical Pumping (SEOP), [4] Dynamic Nuclear Polarization (DNP), [1c] Chemically-Induced Dynamic Nuclear Polarization (CIDNP) [5] photo-CIDNP, [6] Parahydrogen Induced Polarization (PHIP), [7] and Signal Amplification By Reversible Exchange (SABRE). [8] .…”

Section: Introductionmentioning

confidence: 99%

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NMR Hyperpolarization Techniques of Gases

Barskiy

Coffey

Nikolaou

et al. 2016

Chemistry A European J

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Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

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Hyperpolarization Methods for MRS

Abstract: Chekmenev). Co-authored >30 peer-reviewed articles covering advanced MR detection hardware and utilizing hyperpolarization techniques to enable MR contrast agents for in vivo molecular imaging for improved human health.

Cited by 50 publications

References 56 publications

Parahydrogen‐Based Hyperpolarization for Biomedicine

Parahydrogen‐Based Hyperpolarization for Biomedicine

Hyperpolarizing Concentrated Metronidazole ¹⁵NO₂ Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime

NMR Hyperpolarization Techniques of Gases

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Hyperpolarization Methods for MRS

Abstract: Chekmenev). Co-authored >30 peer-reviewed articles covering advanced MR detection hardware and utilizing hyperpolarization techniques to enable MR contrast agents for in vivo molecular imaging for improved human health.

Cited by 50 publications

References 56 publications

Parahydrogen‐Based Hyperpolarization for Biomedicine

Parahydrogen‐Based Hyperpolarization for Biomedicine

Hyperpolarizing Concentrated Metronidazole 15NO2 Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime

NMR Hyperpolarization Techniques of Gases

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Hyperpolarizing Concentrated Metronidazole ¹⁵NO₂ Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime