Hyperpolarized [1‐<sup>13</sup>C]pyruvate MRI for noninvasive examination of placental metabolism and nutrient transport: A feasibility study in pregnant guinea pigs

Friesen-Waldner, Lanette; Sinclair, Kevin J.; Wade, Trevor; Michael, Banoub; Chen, Albert P.; Vrijer, Barbra de; Regnault, Timothy R. H.; McKenzie, Charles A.

doi:10.1002/jmri.25009

Cited by 16 publications

(18 citation statements)

References 36 publications

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“…This hypothesis, although preliminary, deserves further study. Recent advances in 13 C imaging of placenta 36 may provide additional complimentary information on placental metabolic shifts with oxygenation.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

Luo

Türk

Bibbo

et al. 2017

Sci Rep

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Fetal health is critically dependent on placental function, especially placental transport of oxygen from mother to fetus. When fetal growth is compromised, placental insufficiency must be distinguished from modest genetic growth potential. If placental insufficiency is present, the physician must trade off the risk of prolonged fetal exposure to placental insufficiency against the risks of preterm delivery. Current ultrasound methods to evaluate the placenta are indirect and insensitive. We propose to use Blood-Oxygenation-Level-Dependent (BOLD) MRI with maternal hyperoxia to quantitatively assess mismatch in placental function in seven monozygotic twin pairs naturally matched for genetic growth potential. In-utero BOLD MRI time series were acquired at 29 to 34 weeks gestational age. Maps of oxygen Time-To-Plateau (TTP) were obtained in the placentas by voxel-wise fitting of the time series. Fetal brain and liver volumes were measured based on structural MR images. After delivery, birth weights were obtained and placental pathological evaluations were performed. Mean placental TTP negatively correlated with fetal liver and brain volumes at the time of MRI as well as with birth weights. Mean placental TTP positively correlated with placental pathology. This study demonstrates the potential of BOLD MRI with maternal hyperoxia to quantify regional placental function in vivo.

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Section: Discussionmentioning

confidence: 99%

In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

Luo

Türk

Bibbo

et al. 2017

Sci Rep

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“…Recently, a similar study by Friesen-Waldner et al . [42] tested the feasibility of hyperpolarized [1- 13 C]-pyruvate MRI for non-invasive examination of fetoplacental metabolism and nutrient transport in guinea pigs. In contrast to our proposed single fetal-placenta model, the Friesen-Waldner study used a multiple fetal-placenta model observing pyruvate and lactate signals in 30 placentae and fetal livers from seven guinea pigs.…”

Section: Discussionmentioning

confidence: 99%

The chinchilla as a novel animal model of pregnancy

et al. 2017

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Several parameters are important when choosing the most appropriate animal to model human obstetrics, including gestation period, number of fetuses per gestation and placental structure. The domesticated long-tailed chinchilla (Chinchilla lanigera) is a well-suited and appropriate animal model of pregnancy that often will carry only one offspring and has a long gestation period of 105–115 days. Furthermore, the chinchilla placenta is of the haemomonochorial labyrinthine type and is therefore comparable to the human villous haemomonochorial placenta. This proof-of-concept study demonstrated the feasibility in laboratory settings, and demonstrated the potential of the pregnant chinchilla as an animal model for obstetric research and its potential usefulness for non-invasive measurements in the placenta. We demonstrate measurements of the placental and fetal metabolism (demonstrated in vivo by hyperpolarized MRI and in vitro by qPCR analyses), placental vessels (demonstrated ex vivo by contrast-enhanced CT angiography) and overall anatomy (demonstrated in vivo by whole-body CT).

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“…In parallel, Friesen-Waldner et al examined noninvasively the fetoplacental metabolism and transport of pyruvate in guinea pigs using the same technique [72]. The relation between maternal oxygen challenge and fetal oxygenation has recently become possible to study using the blood oxygen-level dependent (BOLD) MRI sequence; a non-invasive technique for evaluating organ tissue oxygenation that requires no contrast exposure ( Figure 3D).…”

Section: Imaging Diagnostics Of the Pregnant Animalmentioning

confidence: 99%

Animal Models of Fetal Medicine and Obstetrics

Andersen¹,

Alstrup²,

Duvald³

et al. 2018

Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy

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Animal models remain essential to understand the fundamental mechanisms occurring in fetal medicine and obstetric diseases, such as intrauterine growth restriction, preeclampsia and gestational diabetes. These vary regarding the employed method used for induction of the disease, and differ in relation to the animal characteristics (size, number of fetuses, placenta barrier type, etc.). While none of these exactly mirrors the human condition, different pregnant animal models (mice, rats, guinea pigs, chinchillas, rabbits, sheep and pigs) are here described with respect to advantages and limitations. The ability to employ noninvasively diagnostics varies among species, specifically for ultrasound and clinical magnetic resonance imaging procedures. Management of feeding, handling, care and anesthesia are particularly important factors in the pregnant animal.

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Hyperpolarized [1‐¹³C]pyruvate MRI for noninvasive examination of placental metabolism and nutrient transport: A feasibility study in pregnant guinea pigs

Abstract: This work demonstrates the feasibility of using hyperpolarized [1-(13) C]pyruvate MRI to noninvasively examine fetoplacental metabolism and transport of pyruvate in guinea pigs. Hyperpolarized (13) C MRI may provide a novel method for longitudinal studies of fetoplacental abnormalities.

Cited by 16 publications

References 36 publications

In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

The chinchilla as a novel animal model of pregnancy

Animal Models of Fetal Medicine and Obstetrics

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Hyperpolarized [1‐13C]pyruvate MRI for noninvasive examination of placental metabolism and nutrient transport: A feasibility study in pregnant guinea pigs

Abstract: This work demonstrates the feasibility of using hyperpolarized [1-(13) C]pyruvate MRI to noninvasively examine fetoplacental metabolism and transport of pyruvate in guinea pigs. Hyperpolarized (13) C MRI may provide a novel method for longitudinal studies of fetoplacental abnormalities.

Cited by 16 publications

References 36 publications

In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

The chinchilla as a novel animal model of pregnancy

Animal Models of Fetal Medicine and Obstetrics

Contact Info

Product

Resources

About

Hyperpolarized [1‐¹³C]pyruvate MRI for noninvasive examination of placental metabolism and nutrient transport: A feasibility study in pregnant guinea pigs