Hyperpolarized129Xe MR Imaging of the Oral Cavity

Albert, Mitchell S.; Tseng, Ching-Hsiang; Williamson, Daniel; Oteiza, E. R.; Walsworth, Ronald L.; Kraft, Bryan; Kacher, Daniel F.; Holman, B.L.; Jolesz, F.

doi:10.1006/jmrb.1996.0084

Cited by 30 publications

(25 citation statements)

References 2 publications

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“…Such studies could be performed by imaging under continuous-breathing conditions, by gating respiration to the MRI spectrometer to synchronize the breathing cycle with acquisition, or by simply having the patient hold his or her breath during acquisition immediately following inhalation of the laser-polarized gas. Inhalation of laser-polarized xenon has also permitted imaging of the oral cavity [222]. of laser-polarized xenon [220].…”

Section: Void Space Imagingmentioning

confidence: 99%

Nuclear Magnetic Resonance of Laser-Polarized Noble Gases in Molecules, Materials, and Organisms

Goodson

2002

Journal of Magnetic Resonance

422

246

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Section: Void Space Imagingmentioning

confidence: 99%

Nuclear Magnetic Resonance of Laser-Polarized Noble Gases in Molecules, Materials, and Organisms

Goodson

2002

Journal of Magnetic Resonance

422

246

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“…The accumulated angular momentum increases the nuclear spin polarization, thereby enhancing the signals in nuclear magnetic resonance (NMR) by up to five orders of magnitude. Magnetic resonance imaging (MRI) of optically polarized 129 Xe and 3 He in the gas phase has already found application in the imaging of the gas space in lungs (4)(5)(6)(7)(8)(9)(10) and other void spaces (11,12) with encouraging results. Given the sensitivity of its NMR parameters to the local environment (13) and its safety for medical applications-it is a well-documented anesthetic (14)-xenon would also be an excellent local probe for the study of tissues in living organisms.…”

mentioning

confidence: 99%

NMR of laser-polarized xenon in human blood

Bifone

Song

Seydoux

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

162

138

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By means of optical pumping with laser light it is possible to enhance the nuclear spin polarization of gaseous xenon by four to five orders of magnitude. The enhanced polarization has allowed advances in nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI), including polarization transfer to molecules and imaging of lungs and other void spaces. A critical issue for such applications is the delivery of xenon to the sample while maintaining the polarization. Described herein is an efficient method for the introduction of laser-polarized xenon into systems of biological and medical interest for the purpose of obtaining highly enhanced NMR͞MRI signals. Using this method, we have made the first observation of the timeresolved process of xenon penetrating the red blood cells in fresh human blood-the xenon residence time constant in the red blood cells was measured to be 20.4 ؎ 2 ms. The potential of certain biologically compatible solvents for delivery of laser-polarized xenon to tissues for NMR͞MRI is discussed in light of their respective relaxation and partitioning properties.

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“…Hyperpolarized noble gas attracts increased attention in a variety of scientific and medical applications, such as polarized targets in fundamental research, 2,3 the search for an atomic electric dipole moment, 4 NMR spectroscopy 5 and MRI of lungs and other organs of the human body. [6][7][8][9] The longitudinal relaxation time, T 1 , characterizes the longevity of such a highly non-equilibrium spin-polarized state. 10 It also sets an upper limit for the transverse relaxation time, T 2 , that characterizes the rate at which the polarized nuclei abandons coherent precession.…”

Section: Introductionmentioning

confidence: 99%

Rapid longitudinal relaxation measurement of hyperpolarized 129Xe by a highly sensitive atomic magnetometer

Wang

Jin

et al. 2017

AIP Advances

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A fast and accurate determination of longitudinal relaxation time is put forward for hyperpolarized 129Xe. The theoretical framework for the method is developed. Measurement of the longitudinal relaxation time is by the determination of a close-loop response of 129Xe magnetization to the external magnetic fields and is implemented with a highly sensitive Rb magnetometer. The indirect measurement dramatically reduces the time consuming than the conventional inversion-recovery method and is more suitable for the samples with long longitudinal relaxation time.

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Hyperpolarized129Xe MR Imaging of the Oral Cavity

Cited by 30 publications

References 2 publications

Nuclear Magnetic Resonance of Laser-Polarized Noble Gases in Molecules, Materials, and Organisms

Nuclear Magnetic Resonance of Laser-Polarized Noble Gases in Molecules, Materials, and Organisms

NMR of laser-polarized xenon in human blood

Rapid longitudinal relaxation measurement of hyperpolarized 129Xe by a highly sensitive atomic magnetometer

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