2023
DOI: 10.3390/molecules28031198
|View full text |Cite
|
Sign up to set email alerts
|

Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange

Abstract: The present work investigates the potential for enhancing the NMR signals of DNA nucleobases by parahydrogen-based hyperpolarization. Signal amplification by reversible exchange (SABRE) and SABRE in Shield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) of selected DNA nucleobases is demonstrated with the enhancement (ε) of 1H, 15N, and/or 13C spins in 3-methyladenine, cytosine, and 6-O-guanine. Solutions of the standard SABRE homogenous catalyst Ir(1,5-cyclooctadeine)(1,3-bis(2,4,6-trimethylphenyl)i… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

1
0
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
2
1

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(1 citation statement)
references
References 77 publications
1
0
0
Order By: Relevance
“…We rationalize the observed temperature trend as follows: the most efficient polarization transfer typically occurs at the exchange rate near J, where J is the relevant spin−spin coupling between p-H 2 -derived hydrides and the to-be-hyperpolarized nucleus. These observations of a clear hyperpolarization temperature maximum are in overall agreement with a wide range of other substrates studied including antifungal agents, 58 DNA bases, 59 N-heterocycles, 60 etc. 46,61 The optimized values of temperature and B T of the SABRE-SHEATH process were employed for the relaxation dynamics studies described further below.…”
Section: ■ Introductionsupporting
confidence: 85%
“…We rationalize the observed temperature trend as follows: the most efficient polarization transfer typically occurs at the exchange rate near J, where J is the relevant spin−spin coupling between p-H 2 -derived hydrides and the to-be-hyperpolarized nucleus. These observations of a clear hyperpolarization temperature maximum are in overall agreement with a wide range of other substrates studied including antifungal agents, 58 DNA bases, 59 N-heterocycles, 60 etc. 46,61 The optimized values of temperature and B T of the SABRE-SHEATH process were employed for the relaxation dynamics studies described further below.…”
Section: ■ Introductionsupporting
confidence: 85%