Hyperprolactinemia and male sexual function: focus on erectile dysfunction and sexual desire

Corona, Giovanni; Rastrelli, Giulia; Bianchi, Nicola; Sparano, Clotilde; Sforza, Alessandra; Vignozzi, Linda; Maggi, Mario

doi:10.1038/s41443-023-00717-1

Cited by 9 publications

(2 citation statements)

References 82 publications

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“…Although the mechanisms of sexual dysfunction in cases with hyperprolactinemia have not been fully elucidated, conceivably hypogonadism is frequently seen in those patients, and at least in some of them hypogonadism is responsible for sexual dysfunction [27].…”

Section: Although Many Etiologic Factors Have Been Blamed For Pe Occu...mentioning

confidence: 99%

Evaluation of Serum Prolactin and Testosterone in Premature Ejaculation Patients

Eid,

Elwan,

Hazzaa

et al. 2023

JAMMR

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Background Premature ejaculation is a frequently encountered sexual dysfunction in men. It significantly impairs quality of life of the affected male and his partner. This study investigated the role of hormonal factors (prolactin and testosterone) in patients with premature ejaculation. Objectives: evaluating the contribution of prolactin and testosterone in the pathogenesis of premature ejaculation. Methods: A group of 26 patients suffering from premature ejaculation;15 of them presented with primary type, and 11 of them complained of secondary type. Another group of 10 subjects served as a control group. All the individuals were subjected to clinical evaluation, and venous blood samples for laboratory investigation of serum prolactin and total testosterone. Results: Comparing the serum prolactin levels between all groups showed no significant statistical differences (p:>0.05). While the levels of total serum testosterone were significantly lower in the primary premature ejaculation patients than in the control group and were more lower in the secondary premature ejaculation patients than both the control and primary type patients (p:<0.05). Conclusion: It is recommended to routinely investigate testosterone serum levels in secondary premature ejaculation patients, especially that is thought to be a high-risk factor in secondary type.

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Section: Although Many Etiologic Factors Have Been Blamed For Pe Occu...mentioning

confidence: 99%

Evaluation of Serum Prolactin and Testosterone in Premature Ejaculation Patients

Eid,

Elwan,

Hazzaa

et al. 2023

JAMMR

View full text Add to dashboard Cite

show abstract

“…The study by Corona et al [4] outlines the framework of HPRL and its correlation with male sexual desire and ED by employing a dual methodological approach, meta-analytical and observational clinical analysis on a series of 4215 men consulting for sexual dysfunction. Clinical and meta-analytic data confirmed a stepwise negative influence of PRL on male sexual desire, whereas the relationship between HPRL and ED has proven to be more uncertain, partly mediated by the lowering of testosterone levels and/or to the reduction of sexual desire itself.…”

mentioning

confidence: 99%

Hormones and sexuality: navigating the complex terrain of the interplay between endocrinology and sexual function

Barbonetti

2024

Int J Impot Res

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Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats

Pfaus,

Antonie,

Dosa

et al. 2023

Psychopharmacology

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Hyperprolactinemia and male sexual function: focus on erectile dysfunction and sexual desire

Cited by 9 publications

References 82 publications

Evaluation of Serum Prolactin and Testosterone in Premature Ejaculation Patients

Evaluation of Serum Prolactin and Testosterone in Premature Ejaculation Patients

Hormones and sexuality: navigating the complex terrain of the interplay between endocrinology and sexual function

Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats

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