Hyperprolactinemia in a Patient with a Pituitary Adenoma Receiving Antipsychotic Drug Therapy

Abstract

Hyperprolactinemia is a common consequence of treatment with an antipsychotic medication. It can result in hypogonadism due to the inhibitory effect of elevated prolactin levels on the hypothalamic-pituitary-gonadal hormonal axis. We present a case of hypogonadism secondary to hyperprolactinemia in a patient taking antipsychotic medication, with radiological evidence of a pituitary microadenoma. The relevance and investigation of hyperprolactinemia in patients being treated with antipsychotic medications are discussed.

Clinical guidelines ‘Hyperprolactinemia’ (draft)

“…• При невозможности отмены или замены лекарственного средства, ассоциированного с повышением уровня пролактина в крови, рекомендовано рассмотреть целесообразность назначения агонистов дофамина после консультации с врачом-психиатром для оценки риска развития психозов [14,15,34].…”