Hyperprolactinemic Male Infertility

Segal, Shmuel; Polishuk, W.Z.; Ben-David, M.

doi:10.1016/s0015-0282(16)42259-4

Cited by 110 publications

(43 citation statements)

References 4 publications

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“…The testicular abnormalities observed in prolactin treated male rabbits confirmed the findings by many investigators [20][21][22][23], who suggested that hyperprolactinemic patients usually suffered from defective sperm maturation, oligospermia, and low androgen production. This may be ascribed to the interference of elevated serum prolactin with spermatogensis through the possibility of prolactin binding to the testis which could interfere with the binding of gonadotropins to the testis or alternatively alter gonadal reaction to gonadotropin [24,25].…”

Section: Studies On Hyperprolactinemic Rabbitssupporting

confidence: 87%

Some Biochemical and Histological Changes during Experimentally Induced Hyperprolactinemia in Male Rabbits

Yousef

Hussein

Heshmat

1988

J. Clin. Biochem. Nutr.

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SummaryDetermination of the effect of prolactin administration on glucose, non-esterified fatty acids, insulin, and liver glycogen concentrations in male rabbit was the aim of the present investigation. Over-secretion of prolactin has been found to be one of the most important causes of male infertility in humans [l, 2] and animals [3,4]. Very little however has been published about the effects of prolactin on carbohydrate metabolism. However, it was reported that lipid abnormalities were most common in infertile men [5]. It was suggested that non-esterified fatty acid (NEFA) level exerts a direct action at the testicular function in man [6]. It was therefore of interest to study the metabolic effect of prolactin on the levels of glucose, NEFA, and insulin in serum and glycogen concentration in liver. This necessiated the establishment of the effect of prolactin administration on the liver and testis and to find to what extent prolactin was responsible for the hepatic and testicular functions in male rabbits.

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Section: Studies On Hyperprolactinemic Rabbitssupporting

confidence: 87%

Some Biochemical and Histological Changes during Experimentally Induced Hyperprolactinemia in Male Rabbits

Yousef

Hussein

Heshmat

1988

J. Clin. Biochem. Nutr.

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“…It is well known that hyperprolactinemia decreases libido and causes oligozoospermia [1]. On the other hand, hyperprolactinemia is caused by or associated with, a variety of pathogenic stages: pituitary adenoma, hypothalamic disorders, hypogonadism and hypothyroidism, and is detected in patients with infertility [2,3], impotence and hypogonadism [4]. PRL is a polypeptide hormone that is synthesized and secreted from mammotropes in the anterior lobe of the pituitary gland [5].…”

Section: Introductionmentioning

confidence: 99%

The Role of Prolactin in the Regulation of Male Copulatory Behavior

Saitô¹,

Olah²,

Terada³

et al. 2013

Prolactin

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“…(T) by increasing the number of LH receptors in Leydig cells [25]. Some reports have not described significant differences in the PRL values of patients with oligo-and normozoospermia [2, 4, 301; others have reported that oligozoospermic [ 15, 261 and azoospermic [28] men have hyperprolactinemia with negative correlation between sperm count and PRL serum concentrations.…”

mentioning

confidence: 99%