Hyperpyrexia as an Adjunct in the Treatment of Non-Surgical Urological Conditions

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

“…Up to 80 to 90% of gonococcal arthritis cases could be cured (70). Pretreatment with mercurochrome in hypertonic glucose was later shown to increase the efficacy of hyperthermia (71). Finally, fewer hyperthermia treatments were usually required with the addition of pelvic heating, i.e., insertion of heating elements for about 2 h into the rectum in men and the vagina in women (sometimes also the rectum), resulting in local temperatures of up to 44°C (72,73).…”

Gonorrhea: Historical outlook

“…[25] Mayo Clinic treated patients with intravenous infusion of mercurochrome in hypertonic glucose followed by hyperthermia. [26] Some investigators suggested that the curative effect may be facilitated by pelvic heating since the infection was focused there. Heating elements were inserted in the vagina and rectum to maintain temperature at about 44°C for about 2 h. [27] Heat therapy became obsolete with the introduction of sulfonamides.…”

Recent Researches on Arthritis and Rheumatism in the United States

“…Further experiences have amply shown that fever therapy provides a potent weapon against gonococcal infections. In the literature reviewed for this survey about a dozen new reports presented the results of fever therapy in about 350 cases of gonorrhceal arthritis.4 [15][16][17][18][19][20][21][22][23] Prompt cure was obtained in about 75 to 90 per cent. of all cases in which it was employed.…”