Hyperresponsiveness of Corticoid-Resistant Th17/Tc-17 Cells to TLR-2 and TLR-4 Ligands is a Feature of Multiple Sclerosis Patients at Higher Risk of Therapy Failure
Joana Hygino,
Marisa Sales,
Priscila Sacramento
et al.
Abstract:Purpose
The presence of T cells expressing TLR-2 and TLR-4 has been associated with relapsing-remitting multiple sclerosis (RRMS) pathogenesis. Here, we evaluated whether the effectiveness of DMT in controlling clinical activity of the disease would be associated with modulation of proportion of TLRs
+
T cells.
Patients and Methods
Whole peripheral blood mononuclear cells, purified CD4
+
and CD8
+
… Show more
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