Hypersegmentation of equine neutrophils

Tvedten, Harold; Riihimäki, Miia

doi:10.1111/j.1939-165x.2007.tb00172.x

Cited by 5 publications

(4 citation statements)

References 2 publications

(4 reference statements)

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“…Most other mammals are comparable to humans regarding segmentation [ 81 ]. These differences already suggest that the often-used definition of hyper-segmentation as the presence of more than five lobes [ 82 , 83 ] cannot be used for all species. Unlike in other animals, equine neutrophils often have more than five lobes ( Figure 2 and Figure 5 ).…”

Section: Morphology and Composition Of Neutrophilsmentioning

confidence: 99%

“…Unlike in other animals, equine neutrophils often have more than five lobes ( Figure 2 and Figure 5 ). The additional long filaments connecting the lobes, the overall long and irregular nuclei, with many of them even folding back on themselves, make accurate counting of lobes in horses difficult [ 83 ]. This can lead to problems if, for example, cell nuclei are counted automatically and software-based, if this software has been established for human neutrophils [ 84 ].…”

Section: Morphology and Composition Of Neutrophilsmentioning

confidence: 99%

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What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?

Fingerhut

Dolz

Buhr

2020

IJMS

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Over the years of evolution, thousands of different animal species have evolved. All these species require an immune system to defend themselves against invading pathogens. Nevertheless, the immune systems of different species are obviously counteracting against the same pathogen with different efficiency. Therefore, the question arises if the process that was leading to the clades of vertebrates in the animal kingdom—namely mammals, birds, amphibians, reptiles, and fish—was also leading to different functions of immune cells. One cell type of the innate immune system that is transmigrating as first line of defense in infected tissue and counteracts against pathogens is the neutrophil granulocyte. During the host–pathogen interaction they can undergo phagocytosis, apoptosis, degranulation, and form neutrophil extracellular traps (NETs). In this review, we summarize a wide spectrum of information about neutrophils in humans and animals, with a focus on vertebrates. Special attention is kept on the development, morphology, composition, and functions of these cells, but also on dysfunctions and options for cell culture or storage.

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Section: Morphology and Composition Of Neutrophilsmentioning

confidence: 99%

Section: Morphology and Composition Of Neutrophilsmentioning

confidence: 99%

What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?

Fingerhut

Dolz

Buhr

2020

IJMS

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“…In most species, the number of nuclear lobes increases with the maturation stage of neutrophils and eosinophils . Cells with bilobed nuclei could thus be erroneously interpreted as immature cells.…”

Section: Discussionmentioning

confidence: 99%

“…28 In most species, the number of nuclear lobes increases with the maturation stage of neutrophils and eosinophils. 29 Cells with bilobed nuclei could thus be erroneously interpreted as immature cells. Nevertheless, their morphology in hedgehogs was different from that of nonsegmented immature granulocytes.…”

Section: Discussionmentioning

confidence: 99%

Hematologic and biochemical variables of hedgehogs (Erinaceus europaeus) after overwintering in rehabilitation centers

Rossi

Mangiagalli²,

Paracchini³

et al. 2014

Veterinary Clinical Pathol

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Background: Information about laboratory reference intervals (RIs) of European Hedgehog (Erinaceus europaeus) hospitalized at rehabilitation centers is scarce. Objective: The purpose of this study was to establish hematologic and biochemical RIs for rehabilitated hedgehogs before the release into the wild, and to assess whether sex and management of the center influence laboratory results. Methods: Blood was collected from 50 hedgehogs at 3 centers. Thirtyeight animals were included in the study based on normal body weight, absence of clinical signs of disease, Bunnell index > 0.80, and absence of hibernation during overwintering. CBCs were performed using an automated laser cell counter followed by morphologic analysis of blood smears. Clinical biochemistry was performed using an automated spectrophotometer. RIs were determined as recommended by the ASVCP guidelines. Results: Hematology profiles revealed a prevalence of lymphocytes, a constant presence of nucleated RBCs, Howell-Jolly bodies and basophils, and bilobed nuclei in neutrophils and eosinophils. Biochemistry profiles were characterized by higher creatinine and urea concentrations, and higher ALP and GGT activities compared with other domestic species. The sex did not influence the results. Conversely, numbers of eosinophils, activated and large granular lymphocytes, and concentrations of total protein, glucose and cholesterol were different among the centers, likely due to different management practices (eg, antiparasitic treatments, environmental exposure to microorganisms, diet).

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Disorders of the Hematopoietic System

Dunkel¹

2018

Equine Internal Medicine

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Hypersegmentation of equine neutrophils

Cited by 5 publications

References 2 publications

What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?

What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?

Hematologic and biochemical variables of hedgehogs (Erinaceus europaeus) after overwintering in rehabilitation centers

Disorders of the Hematopoietic System

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