Hypersensitivity Pneumonitis Related to Imatinib Mesylate

Interstitial pneumonia induced by imatinib mesylate: pathologic study demonstrates alveolar destruction and fibrosis with eosinophilic infiltration

“…There is one report showing a case of hypersensitivity pneumonitis related to imatinib, which may also support the immunoallergic background, but that study lacked pathologic corroboration. 4 Recently, Rosado et al 5 also reported a case of imatinib-induced interstitial pneumonia diagnosed by TBLB, but whose pathological findings were compatible with the nonspecific interstitial pneumonia without eosinophilic infiltration. The above data, taken together with our observations, suggest that imatinib-induced interstitial pneumonia may be heterogeneous and some of them may be likely to involve an immunoallergic mechanism.…”

Twenty-seven cases of drug-induced interstitial lung disease associated with imatinib mesylate

“…Hypersensitivity reaction pattern seems to be as hypersensitivity pneumonitis, as reported in previous articles. 4 However, it is considered that hypersensitivity pneumonitis is an inadequate term for drug-induced ILD because hypersensitivity pneumonitis should be confined to the disease process caused by inhaled antigen. 3 Therefore, we use the term hypersensitive reaction pattern.…”

“…4,[5][6][7][8] Two of three cases histologically showed IP with eosinophilia and nonspecific IP (NSIP), and their CT showed IP pattern, and one showed non-specific histologic finding and IP pattern on CT. The fifth patient was not examined histologically and their radiograph showed PBVB pattern.…”

Drug- Induced Pneumonitis: A Rare Complication of Imatinib Mesylate Therapy in Patients with Chronic Myeloid Leukemia

“…Quite infrequent complications are pulmonary fibrosis and drug-induced pneumonitis [6]. We have some cases of such complications in available literature [7,8,9,10,11,12]. Signs and symptoms of pneumonitis are similar: constitutional symptoms, malaise, low-grade fever, dyspnea (both exertional and at rest), cough, interstitial pulmonary infiltrates [13].…”

“…The resolution of pneumonitis after corticosteroid therapy has been reported. Ohnishi et al [16] reported that pneumonitis developed in 4 of 11 patients with a history of imatinib-induced pneumonitis after reexposure to imatinib [7,13]. Diagnose lung disease caused by taking drugs is not always easy due to lack of specific clinical and morphological manifestations.…”