2022
DOI: 10.1097/pg9.0000000000000205
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Hypersensitivity Reaction to Ustekinumab in Pediatric and Young Adult Inflammatory Bowel Disease Patients: A Case Series

Abstract: Ustekinumab (UST) is a human IgG1K monoclonal antibody that binds to the p40 receptor subunit bound by cytokines IL-12 and IL-23. It is indicated in both Crohn's disease and ulcerative colitis as a second-line agent. The safety and efficacy of UST in children and young adults has not been thoroughly studied. We report a case series of six pediatric patients and young adults who developed hypersensitivity reactions during intravenous infusion with UST. These reactions ranged from mild allergic reactions to anap… Show more

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“…We would like to thank Dr. Sunny et al ( 1 ) for their important contribution on hypersensitivity reactions to intravenous ustekinumab. They report 6 patients who had infusion reactions to intravenous dosing of ustekinumab, 4 of whom subsequently tolerated subcutaneous dosing.…”
mentioning
confidence: 99%
“…We would like to thank Dr. Sunny et al ( 1 ) for their important contribution on hypersensitivity reactions to intravenous ustekinumab. They report 6 patients who had infusion reactions to intravenous dosing of ustekinumab, 4 of whom subsequently tolerated subcutaneous dosing.…”
mentioning
confidence: 99%