Hypersensitivity reactions to metronidazole

García-Rubio, I; Martínez-Cócera, C.; Magadán, Sara Santos; Rodríguez-Jiménez, B; Vázquez-Cortés, Sonia

doi:10.1157/13086750

Cited by 27 publications

(20 citation statements)

References 13 publications

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“…In a study of patients with suspected reactions to beta-lactams (n = 235 MPE), 7% (18/235) had a positive delayed-IDT, while 8.5% (20/235) with negative IDT demonstrated a positive result with OC [147]. IDT has also been used less frequently for other antimicrobials associated with IM-ADRs, such as metronidazole [148]. Limitations include (i) only antimicrobials in a commercially available and sterile injectable form can be utilized, (ii) short-lived local histamine release (e.g.…”

Section: Summary and Recommendationsmentioning

confidence: 99%

Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity

Konvinse

Phillips

White

et al. 2016

Current Opinion in Infectious Diseases

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Purpose of review Antimicrobials are a leading cause of severe T-cell-mediated adverse drug reactions (ADRs). The purpose of this review is to address the current understanding of antimicrobial cross-reactivity and the ready availability of and evidence for in vitro, in vivo and ex vivo diagnostics for T-cell-mediated ADRs. Recent findings Recent literature has evaluated the efficacy of traditional antibiotic allergy management including patch testing, skin prick testing, intradermal testing and oral challenge. While patch and intradermal testing are specific for the diagnosis of immune-mediated (IM) ADRs, they suffer from drug-specific limitations in sensitivity. The use of ex vivo diagnostics, especially ELISpot has been highlighted as a promising new approach to assigning causality. Knowledge of true rates of antimicrobial cross-reactivity aids empirical antibiotic choice in the setting of previous IM-ADRs. Summary In an era of increasing antimicrobial resistance and use of broad-spectrum antimicrobial therapy, ensuring patients are assigned the correct “allergy label” is essential. Re-exposure to implicated antimicrobials, especially in the setting of severe adverse cutaneous reaction is associated with significant morbidity and mortality. The process through which an antibiotic label gets assigned, acted on and maintained is still imprecise. Predicting T-cell-mediated ADRs via personalised approaches, including HLA-typing may pave future pathways to safer antimicrobial prescribing guidelines.

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Section: Summary and Recommendationsmentioning

confidence: 99%

Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity

Konvinse

Phillips

White

et al. 2016

Current Opinion in Infectious Diseases

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“…Chest roentgenographic findings include pleural effusion, basal pulmonary involvement, and elevation of hemidiaphragm [ 1 ]. Metronidazole is the treatment of choice [ 34 ]. Diloxanide furoate, a luminal amoebicidal drug, can eliminate intestinal Entamoeba cysts [ 35 ].…”

Section: Pulmonary Amoebiasismentioning

confidence: 99%

Parasitic Pneumonia and Lung Involvement

Cheepsattayakorn

2014

BioMed Research International

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Parasitic infestations demonstrated a decline in the past decade as a result of better hygiene practices and improved socioeconomic conditions. Nevertheless, global immigration, increased numbers of the immunocompromised people, international traveling, global warming, and rapid urbanization of the cities have increased the susceptibility of the world population to parasitic diseases. A number of new human parasites, such as Plasmodium knowlesi, in addition to many potential parasites, have urged the interest of scientific community. A broad spectrum of protozoal parasites frequently affects the respiratory system, particularly the lungs. The diagnosis of parasitic diseases of airway is challenging due to their wide varieties of clinical and roentgenographic presentations. So detailed interrogations of travel history to endemic areas are critical for clinicians or pulmonologists to manage this entity. The migrating adult worms can cause mechanical airway obstruction, while the larvae can cause airway inflammation. This paper provides a comprehensive review of both protozoal and helminthic infestations that affect the airway system, particularly the lungs, including clinical and roentgenographic presentations, diagnostic tests, and therapeutic approaches.

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“…Chest roentgenographic findings include pleural effusion, basal pulmonary involvement, and elevation of hemidiaphragm [78]. Metronidazole is the treatment of choice [183]. Diloxanide furoate, a luminal amoebiacidal drug can eliminate intestinal Entamoeba cysts [184].…”

Section: Pulmonary Amoebiasis and Hlamentioning

confidence: 99%

Influence of Human Leukocyte Antigen on Susceptibility of Tropical Pulmonary Infectious Diseases and Clinical Implications

Cheepsattayakorn¹

2014

HLA and Associated Important Diseases

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Hypersensitivity reactions to metronidazole

Cited by 27 publications

References 13 publications

Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity

Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity

Parasitic Pneumonia and Lung Involvement

Influence of Human Leukocyte Antigen on Susceptibility of Tropical Pulmonary Infectious Diseases and Clinical Implications

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