Hypersensitivity to Acetylsalicylic Acid (Aspirin)

Prickman, Louis E.; Buchstein, Harold F.

doi:10.1001/jama.1937.02780060011004

JAMA

1937

DOI: 10.1001/jama.1937.02780060011004

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Hypersensitivity to Acetylsalicylic Acid (Aspirin)

Louis E. Prickman¹,

Harold F. Buchstein²

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1937

2001

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Cited by 54 publications

(2 citation statements)

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“…The first indication of severe untoward reactions to ASA was reported about 100 years ago (5). Some sporadic publications (6–10) followed, but it was only after 1967–8 that studies became more frequent and the syndrome was characterized. There appear to be several forms of aspirin sensitivity.…”

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confidence: 99%

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma

Melillo

Balzano

Bianco³

et al. 2001

Allergy

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mentioning

confidence: 99%

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma

Melillo

Balzano

Bianco³

et al. 2001

Allergy

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“…In 1929 Francis 2 emphasized the risk of polypectomy precipitating bronchial asthma in the aspirin‐sensitive patient. By 1937 Prickman and Buchstein 3 analyzed the medical history of aspirin‐sensitive patients. In the late 1960s Samter and Beers 4,5 published several studies on intolerance to aspirin.…”

mentioning

confidence: 99%

Ketorlac‐Induced Status Asthmaticus after Endoscopic Sinus Surgery in a Patient with Samter's Triad

Dias

Biedlingmaier

1997

Otolaryngol.--head neck surg.

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lntolerance to aspirin was described just 3 years after its introduction in 1899. Hirshberg ~ is credited for this description in the German literature in 1903. In 1929 Francis 2 emphasized the risk of polypectomy precipitating bronchial asthma in the aspirin-sensitive patient. By 1937 Prickman and Buchstein 3 analyzed the medical history of aspirin-sensitive patients. In the late 1960s Samter and Beers 4,5 published several studies on intolerance to aspirin. Samter clearly recognized the association of nasal polyposis, bronchial asthma, and aspirin sensitivity. Henceforth, the aspirin sensitivity triad was known as Samter's triad.The natural history of Samter's triad is a chronic rhinitis followed by bronchial asthma and aspirin sensitivity with subsequent development of nasal polyposis. Bronchial asthma may be severe and occasionally intractable. Bronchial asthma in aspirin-sensitive patients occurs, as a rule, in middle age. 6 The bronchial asthma that occurs in aspirin-sensitive patients differs from immunologically induced asthma in that reversibility with bronchodilators is impressive, and required maintenance tends to be less. The onset or aggravation of asthma in these patients frequently follows nasal polypectomy; however, this may be seen up to 9 months after surgery. Nine percent of patients with Samter's triad become free of asthma unless an attack was precipitated by aspirin. 5 Many patients had taken aspirin previously with impunity, followed at a later time by an unexpected reaction. The first aspirininduced reaction may not occur until respiratory manifestations and disease have been present for years. Therefore many reactions are frequently not attributed to the drug. Symptoms of sensitivity are watery rhinorrhea, vivid scarlet flush of head, neck, and chest, bronchoconstriction, wheezing, cyanosis, and occasionally nausea, vomiting, cramps, and diarrhea. This reaction is described as type I hypersensitivity. The explosiveness of the sensitivity reaction is comparable to the anaphylaxis syndrome.Aspirin sensitivity is found in one third of patients with polyps, rhinosinusitis, and asthma. Polyps tend to be bilateral and respond poorly to any type of treatment. Recurrence of From the Division of Otolaryngology-Head and Neck Surgery, the

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Allergy

Rackemann¹

1938

Arch Intern Med (Chic)

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Hypersensitivity to Acetylsalicylic Acid (Aspirin)

Cited by 54 publications

References 13 publications

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma

Ketorlac‐Induced Status Asthmaticus after Endoscopic Sinus Surgery in a Patient with Samter's Triad

Allergy

Contact Info

Product

Resources

About

Hypersensitivity to Acetylsalicylic Acid (Aspirin)

Cited by 54 publications

References 13 publications

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma

Ketorlac‐Induced Status Asthmaticus after Endoscopic Sinus Surgery in a Patient with Samter's Triad

Allergy

Contact Info

Product

Resources

About

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma

Oral and inhalation provocation tests for the diagnosis of aspirin‐induced asthma