Hypersensitivity to Antibiotics

Akinyemi, D'Jahna; Çelik, Gülfem; Adkinson, N. Franklin

doi:10.1017/cbo9780511722240.207

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“…As treatment requires administration of multiple drugs simultaneously, hypersensitivity reactions have been reported in up to 5% of the patients. Non‐immediate and immediate reactions, mostly urticarial rashes, are seen with these drugs, predominantly with rifampicin (4, 5).…”

Section: Desensitization With Anti‐tuberculosis Drugsmentioning

confidence: 99%

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Desensitization to antibiotics in children

Cernadas

2012

Pediatric Allergy Immunology

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Drug hypersensitivity reactions can occur to almost all drugs and antibiotics are among the most common cause for this kind of reactions. Drug hypersensitivity may affect any organ or system, and manifestations range widely in clinical severity from mild pruritus to anaphylaxis. In most cases, the suspected drug is avoided in the future. In case of infection, there is usually a safe antibiotic alternative. Nonetheless, in some cases, no alternative treatment exists for optimal therapy. Under these circumstances, desensitization may be performed. Drug desensitization is defined as the induction of a temporary state of tolerance to a drug which can only be maintained by continuous administration of the medication responsible for the hypersensitivity reaction. Desensitization is mainly performed in IgE-mediated reactions. Increasing doses of the implicated drug are administered over a short period of time, until the therapeutic dose is achieved and tolerated. Very few studies confined to children are found in literature. Most of them are case reports. In general, the proposed desensitization schemes are similar to those used in adults differing only in the final dose administered. The purpose of this study is to review desensitization to antibiotics in children presenting and discussing three clinical practical cases of desensitization in this age group.

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Section: Desensitization With Anti‐tuberculosis Drugsmentioning

confidence: 99%

“…Antibiotics are among the most commonly prescribed drugs in children and are the most likely to be associated with adverse reactions (1–3). Antimicrobial drugs, particularly beta‐lactams (BL), are frequently involved in hypersensitivity reactions (4, 5).…”

mentioning

confidence: 99%

Desensitization to antibiotics in children

Cernadas

2012

Pediatric Allergy Immunology

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show abstract

Hypersensitivity to Antibiotics

Cited by 1 publication

References 0 publications

Desensitization to antibiotics in children

Desensitization to antibiotics in children

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