Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors

Pimiento, A.J. Pérez; Lastra, L. Prieto; Cabreros, M.I. Rodríguez; Sánchez, Luis A.; Mosquera, M. Rodríguez; Cubero, A. García

doi:10.1016/j.jaci.2005.11.001

Cited by 40 publications

(27 citation statements)

References 11 publications

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“…This result confirms previous reports 10,11 and is probably due to the similar chemical structure of these PPIs. On the contrary, patients monosensitized to lansoprazole and rabeprazole, which have a different side chain, had negative test results with omeprazole, pantoprazole, and esomeprazole.…”

Section: Hypersensitivity To Proton Pump Inhibitors: Diagnostic Accursupporting

confidence: 93%

Hypersensitivity to proton pump inhibitors: Diagnostic accuracy of skin tests compared to oral provocation test

Bonadonna

Lombardo

Bortolami

et al. 2012

Journal of Allergy and Clinical Immunology

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Section: Hypersensitivity To Proton Pump Inhibitors: Diagnostic Accursupporting

confidence: 93%

Hypersensitivity to proton pump inhibitors: Diagnostic accuracy of skin tests compared to oral provocation test

Bonadonna

Lombardo

Bortolami

et al. 2012

Journal of Allergy and Clinical Immunology

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“…In the study by Bonadonna et al [13], 4/12 patients who exhibited positive skin tests with the suspected PPI underwent an OPT, and the result was positive in all cases. Additionally, there are case reports showing confirmation of skin test positivity with oral challenge tests with PPIs [1,2,3,6]. Based on these data, we did not perform confirmatory OPTs in patients with skin test positivity to the culprit or alternative PPIs.…”

Section: Discussionmentioning

confidence: 98%

“…Although hypersensitivity reactions due to PPIs are rare, several anaphylactic reactions have been reported [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. The frequency of life-threatening reactions due to immediate hypersensitivity to PPIs and the common usage of these drugs make PPI hypersensitivity a significant problem.…”

Section: Introductionmentioning

confidence: 99%

Management of Hypersensitivity Reactions to Proton Pump Inhibitors: A Retrospective Experience

Özdemir

Erkekol²,

Ünal³

et al. 2016

Int Arch Allergy Immunol

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Background: We previously reported perfect specificity and low sensitivity of skin tests in proton pump inhibitor (PPI)-induced immediate hypersensitivity reactions in a prospective multicenter study. Here, in a retrospective study, we aimed to further evaluate the diagnostic workup procedures and characteristics of the patients with suspected PPI hypersensitivity. Methods: This national multicenter study was conducted as a retrospective chart review of patients with a history of PPI-induced immediate hypersensitivity reaction. A total of 60 patients were included. Results of diagnostic workup procedures (standardized skin-prick, intradermal, and oral-provocation tests with PPIs) and the characteristics of the patients were analyzed. Results: Lansoprazole was the most commonly suspected drug with 41 patients (68.3%), followed by pantoprazole in 12 patients (20.0%), esomeprazole in 6 (10.0%), rabeprazole in 4 (6.7%), and omeprazole in 1 (1.7%). Anaphylaxis (40 patients, 66.7%) was the most common clinical presentation followed by urticaria (17 patients, 28.3%). Diagnostic skin tests with the culprit PPI were positive in 13/26 patients (50.0%). Diagnostic oral-provocation tests were negative in 6/8 patients; 5 of these 6 patients had skin test results with the culprit PPI, and all were negative. Ten patients had at least 1 cross-reactivity. Extensive cross-reactivity (between >2 PPIs) was detected in 4 patients. Conclusions: Lansoprazole was the most frequently implicated drug and anaphylaxis was the most frequent manifestation of PPI-induced hypersensitivity reactions. Physicians should be aware of the possible cross-reactivity among PPIs; however, a safe, alternative PPI can usually be detected by a thorough drug allergy workup.

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“…Few proton pump inhibitors used in everyday practice have been incriminated in rare occasions to induce hypersensitivity reactions. The older preparations omeprazole [6][7][8][9][10], lansoprazole [11][12][13][14] and pantoprazole [15][16][17] have all been, although rarely, associated with hypersensitivity reactions. A recent literature review [14] has shown that only the newest proton pump inhibitors rabeprazol and esomeprazol are free, so far, of such reactions.…”

Section: Discussionmentioning

confidence: 99%

Hypersensitivity to proton pump inhibitors: Lansoprazole-induced Kounis syndrome

Vlahos¹,

Vavilis²,

Giannelou³

et al. 2009

International Journal of Cardiology

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Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors

Cited by 40 publications

References 11 publications

Hypersensitivity to proton pump inhibitors: Diagnostic accuracy of skin tests compared to oral provocation test

Hypersensitivity to proton pump inhibitors: Diagnostic accuracy of skin tests compared to oral provocation test

Management of Hypersensitivity Reactions to Proton Pump Inhibitors: A Retrospective Experience

Hypersensitivity to proton pump inhibitors: Lansoprazole-induced Kounis syndrome

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