Hypersensitivity to lysergic acid diethylamide (LSD-25) and psilocybin in essential headache

Fanciullacci, M; Franchi, G; Sicuteri, F

doi:10.1007/bf01919685

Cited by 16 publications

(19 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The postulated deficiency of 5HT and dopamine creates a central supersensitivity; a condition similar to peripheral denervation supersensitivity. The known susceptibility to hallucinogens such as LSD-25 and psylocibin 24 , shown by EH sufferers can also be attributed to 5HT deficiency.…”

Section: Discussionmentioning

confidence: 99%

Fenfluramine Headache

1976

Self Cite

View full text Add to dashboard Cite

SYNOPSIS Drug acting on brain monoamines (5HT) were tested on EH sufferers. Fenfluramine, an anorectic agent, acts principally on brain 5HT. This drug, when given to EH sufferers, precipitates and aggravates pain. The headache provoked by fenfluramine is tachyphylactic, suggesting involvement of central transmitters. Therapeutic doses of fenfluramine do not affect blood vessel diameter. This further supports a biochemical mechanism for fenfluramine headache. A reversible systemic pain syndrome has been observed in two EH sufferers, treated chronically with fenfluramine. This syndrome appears indistinguishable from that previously observed in EH sufferers, given parachlorophenylalanine, an inhibitor of 5HT synthesis. The effect of fenfluramine supports the hypothesis that established and other experimental anti‐migraine drugs act centrally by correcting abnormalities in the 5HT nociceptive system.

show abstract

Section: Discussionmentioning

confidence: 99%

Fenfluramine Headache

1976

Self Cite

View full text Add to dashboard Cite

show abstract

“…156 However, subjects suffering from headaches are more sensitive to action of hallucinogens and undergo psychotic syndrome after intake of lower psilocybin doses. 157 Administration of higher doses (the amount of about 10-20 mg/70 kg, orally) leads to the elevation of plasma concentration of the drug up to the value of 5-12 ng/mL. 114 Psychotic syndrome starts to develop when psilocin plasma concentration reaches the value of about 4-6 ng/ml.…”

Section: Psilocin Pharmacodynamicsmentioning

confidence: 98%

Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol

Stebelska

2013

Therapeutic Drug Monitoring

View full text Add to dashboard Cite

Psychoactive drugs of fungal origin, psilocin, ibotenic acid, and muscimol among them have been proposed for recreational use and popularized since the 1960s, XX century. Despite their well-documented neurotoxicity, they reached reputation of being safe and nonaddictive. Scientific efforts to find any medical application for these hallucinogens in psychiatry, psychotherapy, and even for religious rituals support are highly controversial. Even if they show any healing potential, their usage in psychotherapy is in some cases inadequate and may additionally harm seriously suffering patients. Hallucinogens are thought to reduce cognitive functions. However, in case of indolealkylamines, such as psilocin, some recent findings suggest their ability to improve perception and mental skills, what would motivate the consumption of "magic mushrooms." The present article offers an opportunity to find out what are the main symptoms of intoxication with mushrooms containing psilocybin/psilocin, muscimol, and ibotenic acid. The progress in analytical methods for detection of them in fungal material, food, and body fluids is reviewed. Findings on the mechanisms of their biologic activity are summarized. Additionally, therapeutic potential of these fungal psychoactive compounds and health risk associated with their abuse are discussed.

show abstract

“…Other studies suggest effects of classic hallucinogen administration on cephalic pain, although the implications are unclear. For example, one study found that participants who regularly suffered from migraine or other “essential” (idiopathic or primary) headaches showed increased psychoactive effects from very low doses of psilocybin and LSD compared to age-matched controls (Fanciullacci et al, 1974). …”

Section: Introductionmentioning

confidence: 99%

Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers

Johnson

Sewell

Griffiths

2012

Drug and Alcohol Dependence

105

View full text Add to dashboard Cite

Background Psilocybin is a well-characterized classic hallucinogen (psychedelic) with a long history of religious use by indigenous cultures, and nonmedical use in modern societies. Although psilocybin is structurally related to migraine medications, and case studies suggest that psilocybin may be efficacious in treatment of cluster headache, little is known about the relationship between psilocybin and headache. Methods This double-blind study examined a broad range of psilocybin doses (0, 5, 10, 20, and 30 mg/70 kg) on headache in 18 healthy participants. Results Psilocybin frequently caused headache, the incidence, duration, and severity of which increased in a dose-dependent manner. All headaches had delayed onset, were transient, and lasted no more than a day after psilocybin administration. Conclusions Possible mechanisms for these observations are discussed, and include induction of delayed headache through nitric oxide release. These data suggest that headache is an adverse event to be expected with the nonmedical use of psilocybin-containing mushrooms as well as the administration of psilocybin in human research. Headaches were neither severe nor disabling, and should not present a barrier to future psilocybin research.

show abstract

Hypersensitivity to lysergic acid diethylamide (LSD-25) and psilocybin in essential headache

Cited by 16 publications

References 8 publications

Fenfluramine Headache

Fenfluramine Headache

Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol

Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers

Contact Info

Product

Resources

About