Hypersensitivity to Pancuronium in a Patient With Von Recklinghausen’s Disease

Nagao, H; Yamashita, Mami; Shinozaki, Y.; Oyama, T

doi:10.1093/bja/55.3.253

Cited by 5 publications

(3 citation statements)

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“…While in Neurofibromatosis (NF) complex, inhalational induction with sevoflurane is recommended [6] there is a lot of evidence suggesting enhanced sensitivity of NFI patients to non-depolarizing muscle relaxant drugs [7][8][9]. Other associated abnormalities may also contribute to the difficulties.…”

Section: Anaesthestic Considerationsmentioning

confidence: 99%

Editorial: Anaesthesia and Genetics: Still, the Uncharted Territories!!

Panditrao¹

2016

JACCOA

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Section: Anaesthestic Considerationsmentioning

confidence: 99%

Editorial: Anaesthesia and Genetics: Still, the Uncharted Territories!!

Panditrao¹

2016

JACCOA

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Section: Anaesthestic Considerationsmentioning

confidence: 99%

Editorial: Anaesthesia and Genetics: Still, the Uncharted Territories!!

Panditrao¹

2016

JACCOA

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“…6 61 62 69 70 114 In addition, the sensitivity to succinylcholine has been reported as increased, 61 62 114 decreased 6 or normal. 62 69 However, these reports are marred by a paucity of detail preventing a de®nite diagnosis of neuro®bromatosis to be established; in addition, with the exception of one study, 6 no neuromuscular monitoring was performed. A large retrospective study of patients given succinylcholine and/or a variety of nondepolarizing neuromuscular blocking drugs with neuromuscular monitoring excluded any de®nite abnormal response to the relaxants given.…”

Section: Pharmacologymentioning

confidence: 99%

Neurofibromatosis: clinical presentations and anaesthetic implications

Hirsch

Murphy

Radcliffe

2001

British Journal of Anaesthesia

134

150

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The neurofibromatoses are autosomal dominant diseases that have widespread effects on ectodermal and mesodermal tissue. The commonest member of the group is neurofibromatosis type 1 (NF1) which varies in severity but which can affect all physiological systems. Neurofibromas are the characteristic lesions of the condition and not only occur in the neuraxis but may also be found in the oropharnyx and larynx; these may produce difficulties with laryngoscopy and tracheal intubation. Pulmonary pathology includes pulmonary fibrosis and cystic lung disease. The cardiovascular manifestations of NF1 include hypertension, which may be associated with phaeochromocytoma or renal artery stenosis. Neurofibromas may also affect the gastrointestinal tract and carcinoid tumours may be found in the duodenum. This review documents the aetiology and clinical manifestations of the neurofibromatoses and discusses their relevance to the anaesthetist.

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Hypersensitivity to Pancuronium in a Patient With Von Recklinghausen’s Disease

Cited by 5 publications

References 0 publications

Editorial: Anaesthesia and Genetics: Still, the Uncharted Territories!!

Editorial: Anaesthesia and Genetics: Still, the Uncharted Territories!!

Editorial: Anaesthesia and Genetics: Still, the Uncharted Territories!!

Neurofibromatosis: clinical presentations and anaesthetic implications

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