The semi-arid region of Northeastern part of Brazil is under changes pressures driven by human activities or climate changes. This study aims to assess the vegetation coverage in two periods, before the transposition of the São Francisco River-East axis, and after your implementation, in the Moxotó River basin using remote sensing techniques to determine vegetation indices, and investigate the behavior of vegetation in the catchment area. The Normalized Difference Vegetation Index (NDVI) and the Soil Adjusted Vegetation Index (SAVI). TM-Landsat5 image of 13/01/2009, and OLI-Landsat8 image of 04/02/2017 are used here. Radiometric calibration steps, reflectance are developed to generate thematic maps of NDVI and SAVI. The NDVI showed average values for 2009 and 2017 like 0,256 and 0,264, respectively, setting a growth of vegetation cover and photosynthetic activity. The SAVI had an average of 0,147 and 0,155 to years of 2009 and 2017, respectively. Differences were found between vegetable toppings determined by NDVI and by SAVI. The exposed soil class had greater expression when observed in the thematic maps of NDVI, once the SAVI, has the precept to reduce the brightness of the ground, and this index had a higher representation in the sparse vegetation.