Hyperspectral imaging fluorescence excitation scanning spectral characteristics of remodeled mouse arteries

Deal, Joshua; McFarland, Stuart J.; Robinson, Anna; Alford, Anna; Weber, David S.; Rich, Thomas C.; Leavesley, Silas J.

doi:10.1117/12.2510770

Cited by 1 publication

(1 citation statement)

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“…Deal et al investigated the contributions of normal and neoplastic colonic autofluorescence, which is the reflectance observed from the endogenous fluorescent molecules in biological tissue, using excitation wavelengths from 360 to 550 nm and emission at 555 nm, separated with a long-pass emission filter and dichroic beamsplitter [108]. Investigating neoplastic tissues, colorectal adenocarcinoma and adenomatous polyps, demonstrated that some autofluorescent molecules, such as elastin and nicotinamide adenine dinucleotide (NADH), had a significantly different abundance compared to normal colonic tissues, while other molecules, such as collagen, flavin adenine dinucleotide (FAD), and protoporphyrin IX (PPIX), showed no change between normal and neoplastic tissues.…”

Section: Cancer Optical Propertiesmentioning

confidence: 99%

In-Vivo and Ex-Vivo Tissue Analysis through Hyperspectral Imaging Techniques: Revealing the Invisible Features of Cancer

Halicek

Fabelo

Ortega

et al. 2019

Cancers

178

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In contrast to conventional optical imaging modalities, hyperspectral imaging (HSI) is able to capture much more information from a certain scene, both within and beyond the visual spectral range (from 400 to 700 nm). This imaging modality is based on the principle that each material provides different responses to light reflection, absorption, and scattering across the electromagnetic spectrum. Due to these properties, it is possible to differentiate and identify the different materials/substances presented in a certain scene by their spectral signature. Over the last two decades, HSI has demonstrated potential to become a powerful tool to study and identify several diseases in the medical field, being a non-contact, non-ionizing, and a label-free imaging modality. In this review, the use of HSI as an imaging tool for the analysis and detection of cancer is presented. The basic concepts related to this technology are detailed. The most relevant, state-of-the-art studies that can be found in the literature using HSI for cancer analysis are presented and summarized, both in-vivo and ex-vivo. Lastly, we discuss the current limitations of this technology in the field of cancer detection, together with some insights into possible future steps in the improvement of this technology.

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Section: Cancer Optical Propertiesmentioning

confidence: 99%